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Acalm (Alprazolam)

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Acalm is used to treat anxiety and panic disorders. It belongs to a class of medications called benzodiazepines which act on the brain and nerves (central nervous system) to produce a calming effect. It works by enhancing the effects of a certain natural chemical in the body (GABA). Acalm is mostly used to treat anxiety disorders, panic disorders, and nausea due to chemotherapy. Acalm may also be indicated for the treatment of generalized anxiety disorder, as well as for the treatment of anxiety conditions with co-morbid depression. The FDA label advises that the physician should periodically reassess the usefulness of the drug.

Other names for this medication:
Aaram, Aldep, Alpkair, Alpra, Alpranex, Alprawin, Alprosym, Alzac, Alzam, Alzoact, Ambulax, Benzolam, Cqlam, Deproz, Depten, Depwell, Enxolam, Exiten, Ezoprax, Himzolam, Manzolam, Mebasap, Meloprax, Nexlpra, Orten, Pacyl, Pronil, Prosanti, Prozolam, Rezolam, Riolam, Samprex, Silam, Suzilam, Synozolam, Tagat, Texidep, Tranax, Zedel, Zolam, Zolar, Zolin, Zolorel, Zomark, Zopax

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Cleocin, Pamelor, Maxolon, Imitrex, Amethopterin, Seroquel

Also known as: Alprazolam


Alprazolam is used to relieve symptoms of anxiety, including anxiety caused by depression. It is also used to treat panic disorder in some patients.

Alprazolam is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system.

This medicine is available only with your doctor's prescription.


Usual Adult Dose for Anxiety:

Immediate-release tablets: 0.25 to 0.5 mg orally administered 3 times a day -Maximum dose: 4 mg/day

Usual Adult Dose for Panic Disorder:

Immediate-release tablets: 0.5 mg orally administered 3 times a day -Maximum dose: 10 mg/day Extended-release tablets: -Initial dose: 0.5 to 1 mg orally once a day -Maintenance dose: 3 to 6 mg orally per day, preferably in the morning -Maximum dose: 10 mg/day Comments: -The lowest possible effective dose should be administered and the need for continued treatment reassessed frequently. -Dosage should be reduced gradually when discontinuing therapy or when decreasing the daily dosage. -The daily dosage may be decreased by no more than 0.5 mg every 3 days; however, some patients may require an even slower dosage reduction. -The dose of extended-release tablets may be increased at intervals of 3 to 4 days in increments of no more than 1 mg per day. -The times of administration should be distributed as evenly as possible throughout the waking hours.

Usual Geriatric Dose for Anxiety:

Elderly or debilitated patients: Immediate-release tablets: 0.25 mg orally administered 2 or 3 times a day.

Usual Geriatric Dose for Panic Disorder:

Elderly or debilitated patients: Immediate-release tablets: -Initial dose: 0.25 mg orally administered 2 or 3 times a day Extended-release tablets: -Initial dose: 0.5 mg orally once a day Comments: -If side effects develop, the dose may be lowered. -The lowest possible effective dose should be administered and the need for continued treatment reassessed frequently. -Dosage should be reduced gradually when discontinuing therapy or when decreasing the daily dosage.

Detailed Acalm dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of alprazolam can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, and fainting.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is very important to protect the orally disintegrating tablets from moisture. Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine.

Detailed Acalm dosage information

Side effects

The most common side effects associated with Acalm are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.

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We explored roles for ALDH3A1 in conferring resistance to chemotherapeutics/radiation/oxidative stress and whether ectopic overexpression of ALDH3A1 could lead to alterations of gene expression profile associated with cancer stem cell-like phenotype. Additionally, ES cells are an excellent model for studies of early developmental processes. Finite-size and correlation-induced effects in mean-field dynamics. Deposition of activated complement in the vessels of COPD lung as well as autoantibodies against endothelial cells were also observed. Exploring the impact of climate variability during the Last Glacial Maximum on the pattern of human occupation of Iberia. Furthermore, dissolved and colloidal uranium species in the leaching solutions were monitored by Capillary Electrophoresis (CE) coupled to ICP-MS, in order to investigate the uranium/colloids interactions. It has been suggested that dental instruments can be used as bridging instruments to facilitate electric pulp testing of teeth with extensive restorations.

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However, on the CAP factor scales, only the rigidity and unhappiness factors discriminated between abusive and nonabusive mothers with a childhood history of abuse. SRIF was practically restricted to the parvicellular periventricular subdivision. The HADS-T appears to be a suitable screening instrument for ruling out those lung cancer patients and partners without a psychiatric disorder. We performed a study over a period of seven months in 2010 to survey the circulation of Klebsiella pneumoniae carbapenemases (KPC) ina 1,500-bed university hospital in northern Italy and report the presence and rapid increase of these multidrug-resistant bacteria. These data prompt us to suggest that the immunocytochemical localization and evaluation of alpha sm-1, Thy-1, ATIII, and urokinase in kidney allografts may be useful adjuncts in the assessment of function in renal allografts. The combined expression of Semaphorin4D and PlexinB1 predicts disease recurrence in colorectal cancer. We also tested the effect of egg washing with de-ionized water on oviposition rates.

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Avian egg white preparations may facilitate adhesin characterization of wild-type uropathogenic strains and may useful in preventing upper urinary tract infections due to P-fimbriated E. It has been suggested that dietary modifications in combination with genetic predisposition play an important role in the pathogenesis of NAFLD. The findings show that organisational culture tends to be more influential on innovation process and cross-functional organisation in Malaysian telecommunication industry. Thus, morphological and biochemical evidence has been obtained that Modafinil in the dose range 10-100 mg/kg protects against MPTP-induced degeneration of the nigrostriatal DA neurons of the black mouse.(ABSTRACT TRUNCATED AT 400 WORDS). Insulin-like growth factor-binding protein-3 proteolysis is induced after elective surgery. Synchronous tuberculosis, Epstein-Barr virus-associated lymphoproliferative disorder and cytomegalovirus infection in an allogeneic transplant recipient: a case report. Previous statin therapy before ACS was associated with milder clinical presentation and lower incidence of in-hospital MACE after early invasive strategies. Our results show that, at amino acid (AA) site 372, one of the two sites that distinguish Pgi-f (the translated polypeptide of the Pgi-f allele) from Pgi-non-f (the translated polypeptide of the Pgi-non-f allele), the Pgi-non-f-related residue strengthens an electrostatic attraction between a pair of residues (Glu373-Lys472) that are from different monomers, compared to the Pgi-f-related residue.

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The effects of nanocomposites on HNE-1 cells proliferation and apoptosis were measured with Cell Counting Kit-8(CCK-8) and flow cytometry. Tectal cells that projected to the contralateral pontine reticular formation were predominantly located in the intermediate gray layer. Methylation-sensitive high resolution melting (MS-HRM) is unique among regularly used methods for DNA methylation analysis in that heterogeneous methylation can be readily identified, although not quantified, by inspection of the melting curves. While travelling through these zones, concentrations of potential pathogens should decline to levels that pose no risks to human health. Children in pain: recurrent back pain, abdominal pain, and headache in children and adolescents in a four-year-period. General examination by a general practitioner, together with measurements of blood glucose and serum cholesterol concentrations. Increasing incidence of brain metastasis in patients with advanced hepatocellular carcinoma in the era of antiangiogenic targeted therapy. This would offer potential and substantial savings in the financial cost of treating an otherwise avoidable disease. However, the response to red light was much smaller in tobacco than in pea and was not efficiently reversed by far-red light. The endometrium secretes platelet activating factor (PAF) and leukaemia inhibitory factor, which increase after reactivation.

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Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart disease in which mutations affecting Plakophilin-2 (PKP2) are the most frequently detected. This work opens the way to using electro-osmotic pumping in a wide range of applications, from membrane-based ultrafiltration and nanofiltration (as a more efficient alternative to mechanical pumping at the nanoscale) to further miniaturization of lab-on-a-chip devices at the nanoscale for in vivo implantation. These injuries are potentially serious with risk of damage to multiple organs. The method has been tested with as little as 2 micrograms of bovine fetuin, with a glycopeptide from bromelain and with an oligosaccharide after periodate oxidation. New insights of myositis-specific and -associated autoantibodies in juvenile and adult type myositis. To compare treatment of exudative age-related macular degeneration (AMD) with bevacizumab versus aflibercept in terms of central retinal thickness (CRT) and best corrected visual acuity (BCVA). coli of the urocanase gene from white clover (Trifolium repens). Compensations took the form of a measured increase in range of motion, an observed adoption of a new posture during task execution, and prepositioning of items in the workspace prior to initiating a given task.

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Impact of Valsalva maneuver on central choroid, central macula, and disk fiber layer thickness among high myopic and hyperopic patients. The main reason of the loss of the ability to carry introduced compressing forces in the joint and possibility of cracks initiation in plates during the operation has been clarified. Despite this intensive therapy, the disease recurred and the patient died 10 months after the diagnosis. Psychosocial factors as predictors for early retirement in patients with chronic low back pain. After repeated ip and oral administrations of ciguatoxin (CTX) and ciguatoxin-4c (CTX-4c), one of the derivatives of CTX, to male ICR mice at a dose of 0.1 microgram/kg for 15 days, resulted in marked swelling of cardiac cells and endothelial lining cells of blood capillaries in the heart was observed. The results indicated that the epitopes recognized by the two antibodies are probably close together at the surface of the toxin, thus preventing the simultaneous binding of both mAbs to a single toxin molecule. Stress physiology of migrant birds during stopover in natural and anthropogenic woodland habitats of the Northern Prairie region. Selected studies highlighting specific aspects of beta-agonist use in acute asthma such as beta-agonists versus other bronchodilators, aerosol delivery, and intravenous beta-agonists were also reviewed. The 2 remaining populations were given a standard Spielberger State Anxiety survey for anxiety assessments against control populations.

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Insulin release during normoglycemia can be modulated by exogenous insulin infusion and directly depends on whole-body insulin sensitivity. In the first stage (stage of early status epilepticus), buccal midazolam has become an important out-of-hospital treatment option. We compared the transfusion practices in cardiothoracic surgery before and after implementation of a novel clinical decision support (CDS) tool. Transmission of 100-MHz-range ultrasound through a fused quartz fiber. Analysis of the structure of this fragment suggests that it contains two growth factor-like domains that may have a functional role. A novel H/D exchange mass spectrometry approach was developed to assess protein interactions with quadruplex DNA.

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Spastic equinus, resulting from severe head injury in children, can greatly impede their rehabilitation. ApoA-II directs morphogenetic movements of zebrafish embryo by preventing chromosome fusion during nuclear division in yolk syncytial layer. Thus, the above results are direct evidence that even the endogenous self molecule, when constitutively expressed, does act as a tumor Ag. Neurosurgical treatment with thermocoagulation, chemical glycerol-rhizotomy and microsurgical decompression. To assess the effect of blood transfusion on the development of infection after elective operations for gastrointestinal and pancreatic cancer.

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Imidazolium-embedded iodoacetamide-functionalized silica-based stationary phase for hydrophilic interaction/reversed-phase mixed-mode chromatography. Relation between fractional flow reserve value of coronary lesions with deferred revascularization and cardiovascular outcomes in non-diabetic and diabetic patients. We also discuss the current recommendations for screening non-Hodgkin lymphoma patients for HBV and the role of prophylactic antiviral therapy during and after immunosuppressive treatment. The patient underwent surgical intervention for diagnostic and therapeutic purposes. The objective of this study was to investigate a modified protocol in which trehalose is combined with dimethyl sulfoxide (Me2SO) to improve the pigmentation of skin grafts. We found that IgG was successfully immobilized on the fluorocarbon glow discharge treated surfaces by using either the physical adsorption or the glutaraldehyde coupling method, although the former is more efficient than the latter method. Establishing a role of the dorsal medial frontal cortex in the performance monitoring and cognitive control has been a challenge to neuroscientists for the past decade. Haemorrhages due to traumatic injury or secondary to tumours, thrombosis of the venous sinuses and patients who were not treated in the service were all excluded. Fetal endothelium dysfunction is associated with circulating maternal levels of sE-selectin, sVCAM1, and sFlt-1 during pre-eclampsia. Inhibition of quorum-sensing-mediated biofilm formation in Cronobacter sakazakii strains.

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Furthermore the subjects more oriented to morningness chronotype were found to be prone to adopt safe driving behaviour. Characterization of Spanish ciders by means of chemical and olfactometric profiles and chemometrics. On the last day of each experimental period, blood samples were taken from the jugular vein at zero (before feeding), 30, 60, 120, 240 or 360 min after the feeding of the diet. Overall, the results of this research indicated that the sensory attributes of leafy vegetables during 180 days of frozen storage were affected mainly by freezing temperature rather than frozen storage time. Radiation modality use and cardiopulmonary mortality risk in elderly patients with esophageal cancer. An increase in the numbers of lysosomes and electron dense bodies was examined. Characterization of a mouse/human chimeric monoclonal antibody (C beta 1) to a principal neutralizing domain of the human immunodeficiency virus type 1 envelope protein. Propranolol increased neointimal thickening, lipid accumulation, an increase in cell number and in the collagen content. We examined potential sources of heterogeneity in random-effects metaregression analyses.

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However, acquiring an additional radiograph during abdominal compression greatly increased the chance of obtaining at least one radiograph with maximal diagnostic information during the pyelographic phase. The density and tortuosity of the subbasal corneal nerve plexus were also evaluated. The CONDOP package provides a deeper insight into RNA-seq data analysis and allows scientists to highlight the operon organization in the context of transcriptional regulation with a few lines of code. Acute pancreatitis is a rare, but fatal, manifestation of systemic lupus erythematosus. Characterization of the immediate effect of a training session on a manual wheelchair simulator with haptic biofeedback: towards more effective propulsion. This study evaluates the effects of Astym therapy upon (1) range of motion and (2) subjective functional improvements in post-TKA patients who suffered from stiffness recalcitrant to other nonoperative interventions. To investigate the relationship between aberrant methylation of Syk and Runx3 genes and recurrence and metastasis after resection of gastric cancer. We suggest that both calcium antagonist and agonist can change the tension of the urinary bladder in vivo. Treatment-related adverse events were mild hypertension (grade 1), diarrhea (grade 1), and fatigue (grade 1).

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The aim of this study is to examine the association between maternal age at delivery and CHD prevalence in the North of England. Since they are easy to transmit, the majority of infections were protozoan. The enough voluminous of different physical factors combined influences were investigated, their reciprocally modified influences to the organism tolerance were estimated. Purification and characterization of Plasmodium yoelii adenosine deaminase. EPLBD without EST may be safe and effective in patients with a large bile duct stone. From colloidal stability aceon dose in ionic liquids to advanced soft materials using unique media. Basically, although both substances have anesthetic properties and both act to functionally increase catecholaminergic function, especially that of dopamine, there are some differences in their actions.

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Thermoluminescence, OSL and defect centers in Tb doped magnesium orthosilicate phosphor. Perception of emotion in psychiatric disorders: on the possible role of task, dynamics, and multimodality. Examination of human meibum collection and extraction techniques. We herein present the first reported case of an adult trauma patient presented side effects of exelon patch overdose with an impaled knife protruding out of lower back, who underwent endotracheal intubation with an intubating laryngeal mask airway under general anesthesia in the prone position. Different predictor variables emerged as important for orofacial and limb-truncal dyskinesia.

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Overcoming Instability of Antibody-Nanomaterial Conjugates: Next Generation Targeted Nanomedicines Using Bispecific Antibodies. Oct-1 is a ubiquitously expressed POU domain transcription factor. Here, we deploy Mycobacterium marinum-infected zebrafish larvae for in vivo characterization of antitubercular drug activity and tolerance. Based on encouraging findings in other hematological cancers, future research should examine the feasibility and effectiveness of physical activity in MPN patients. There are important limitations to our current clinical knowledge of depression in DS. Feature combinations corresponding to sedentary energy expenditure, sedentary heart rate, and sex alone resulted in errors that were higher than speed-based models and nearest-neighbor models. The final survey was distributed by email to 134 intensivists from 17 PICUs across Canada using the Research Electronic Data Capture system. Here we demonstrate that in response to alcohol, increased claudin-5 paradoxically accompanies an increase in paracellular leak and rearrangement of alveolar tight junctions. Thus, attentional entrainment appears to tune a network of trileptal cost 300mg brain areas to the temporal dynamics of behaviorally relevant event streams, contributing to its perceptual and behavioral selection. We identify the growth of the number of components as a signature of this anomalous transition.

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Cryoablation is a low risk, well-tolerated topical treatment for the pain of patients with unresectable paravertebral malignant mesenchymal tumor. infectoria synthesizes melanin in response to certain antifungal drugs, and its susceptibility is influenced by melanization, suggesting the therapeutic potential of drug combinations that affect melanin synthesis. Direct injection of these agonists into the paraventricular nucleus of the hypothalamus (PVN) and its effect on GH secretion were also investigated. Nowadays, a plethora of approaches are available to rejuvenate the human body and face, the latter being a frequent target for the placement of filling substances to correct wrinkles and volume loss. The wideband Doppler method is applied to generate a color flow image, and the validity of the method is experimentally confirmed. Based on these results, the developed immunochromatographic strip assay is efficient for the detection of C. However, the importance of dimerization in GEF localization and function has not been assessed. Postprandial and 6-h fasting blood glucose levels, blood A1C level, oral glucose tolerance and pancreas insulin content were measured during or after the treatment period.

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Arts and Tatenhove conceptualise power in policy-making in relational, dispositional and structural layers. The allograft reconstructed knees demonstrated normal patterns of rotation whereas the metal subjects had abnormal patterns of rotation and statistically significant differences in rotational moments. The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen. Bone marrow transplantation in phosphoglycerate kinase (PGK) deficiency. Self-Construals, Anger Regulation, and Life Satisfaction in the United States and Japan. Within moderate-to-severe OSA patients, PAP usage prevents increases in adhesion molecules observed in nonusers after 2 years. The perception of unfulfilled expectations (psychological contract breach) was found to moderate the perceived organizational support-work outcome relationships adversely. The immunoblot revelead three covalent protein complexes of about 108, 77 and 33 kDa containing FAPB4 and its putative receptor. Total antioxidant capacity, catalase activity, and lipid peroxidation changes in seminal plasma of sex-reversed female and male rainbow trout (Oncorhynchus mykiss) during spawning season. The virus-specific cytotoxic T lymphocyte (CTL) induction is an important target for the development of a broadly protective human influenza vaccine, since most CTL epitopes are found on internal viral proteins and relatively conserved.

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The functional significance of vagal preganglionic cell bodies in DMN whose axons contribute to the pulmonary branches of the vagus nerve remains to be determined. Because all of the family members had diseases of the pancreas, colon, and liver, we question whether the heterozygote state contributes to the impaired function of these organs. Further, polymer blend compatibilization is considered due to similar molecular relationships and polarities. Immunohistochemistry confirmed mRNA data and revealed a marked expression of P-gp within sweat ducts, vessels, nerve sheaths and muscles of human skin and a moderate expression in basal epidermis. In six male pseudohermaphrodites, magnetic resonance imaging studies of the prostate were also performed. To investigate whether the use of systemic glucocorticoids is a risk factor for community-acquired Staphylococcus aureus bacteremia (CA-SAB). This editorial discusses the pros and cons biaxin classification of drug of community treatment orders (CTOs) from the perspective of community general adult psychiatry. Solutions far from it are oscillatory whereas the separatrix solution is of a soliton type.

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Influence of Actinobacillus pleuropneumoniae serotype 2 and its cytolysins on porcine neutrophil chemiluminescence. We also discuss the unsatisfactory clinical experience of interpreting MRI scans in individual FTD cases, especially the behavioural presentations (without aphasic or motor impairments). Human MSCs highly stimulate the growth and expression of CD90, partial CD73 and CD105 in ovarian cancer cells during co-culturing. A novel, quantitative bioassay for type I interferon using a recombinant indicator cell line. Injury- and ischemia-induced angiogenesis is critical for tissue repair and requires nitric oxide (NO) derived from endothelial nitric oxide synthase (eNOS). By optimizing pH and dilution rate in chemostat cultures the daily yield of human IgM increased nearly threefold from 6 to 16 mg/day and per litre of reactor volume.

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We develop a model of bistable oscillator with nonlinear dissipation. While citizen participation has become a commonplace element in many planning efforts, both planners and citizens often assess the participatory elements as being unsatisfactory. Corrigendum: Can Nanofluidic Chemical Release Enable Fast, High Resolution Neurotransmitter-Based Neurostimulation?. Institutional care for the elderly: the impact and implications of the ageing population. The findings from this study have informed key decisions made for the deployment of this measure as part of the DUQuA study. The selectivity of the ELIME and RTi-PCR assays was proved by inclusivity and exclusivity tests performed analyzing different Salmonella serotypes and non-target microorganisms, most commonly isolated from environmental sources. Here, we report the genomic occurrences and evolutionary relationships or phylogenomics of all three PIK families across major eukaryotic groups and suggest potential ramifications for drug discovery.

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