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Actalipid (Simvastatin)

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Actalipid is a cholesterol-lowering medication which used to treat high cholesterol levels in the blood. It works by blocking the production of cholesterol in the body, thus can help prevent conditions that can lead to heart attack, heart disease and hardening of the arteries, stroke, and vascular disease. This medication can also reduce these risks in people with diabetes, peripheral vascular disease, and a history of stroke. Use this medication during low fat diet to get the best result.

Other names for this medication:
Actalipid, Docsimvasta, Dosavastatin, Lipex, Lipinorm, Lodales, Normotherin, Simbastatin, Simgal, Simvastatin, Simvastatina, Simvastatinum, Simvofix, Sinvacor, Sivastin, Statinal, Vasilip, Zocord, Zorced, Zorstat, Zosta, Zostin, Zostine, Zovast, Zovastin, Zovatin, Zurocid

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Also known as: Simvastatin


Actalipid is an HMG-CoA reductase inhibitor. Actalipid is used to: reduce the risk of heart attack, stroke, and death due to coronary heart disease; reduce the risk of heart attack, stroke, blood vessel blockage, or chest pain caused by angina; low high cholesterol and triglycerides; increase high-density lipoprotein (HDL, "good") cholesterol levels. Actalipid is also known as Imvastatin, Simlup, Simcardis, Ranzolont, Simvador. Actalipid works by reducing the production of certain fatty substances in the body, including cholesterol. Generic name of Actalipid is Simvastatin. Brand name of Actalipid is Actalipid.


Take Actalipid exactly as prescribed. Follow all directions on your prescription label. Never take this medicine in larger amounts, or for longer than prescribed. Taking too much of this medication may cause serious or life-threatening side effects.

Actalipid is usually taken at bedtime or with an evening meal. If you take this medicine more than once daily, take it with meals. Your doctor may occasionally change your dose to make sure you get the best results.

While using Actalipid, you may need frequent blood tests at your doctor's office.

You may need to take Actalipid on a long-term basis for the treatment of high cholesterol. You may need to stop using this medicine for a short time if you have surgery or a medical emergency. Do not stop taking this medicine unless your doctor tells you to.

Actalipid is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

Store at room temperature away from moisture, heat, and light.

Detailed Actalipid dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature below 30 degrees C (86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Actalipid are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Grapefruit and grapefruit juice may interact with simvastatin and lead to unwanted side effects. Avoid the use of grapefruit products while taking Actalipid.

Avoid eating foods that are high in fat or cholesterol. Actalipid will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.

Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage.

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A pH/enzyme-responsive polymer film consisting of Eudragit FS 30 D and arabinoxylane as a potential material formulation for colon-specific drug delivery system. In the analysis of serial sections stained with 5 peptides (SP, NPY, ENK, VIP, CGRP), fibers containing these peptides were found to be densely accumulated in specific areas of the transplanted spinal cord. It might be concluded that IH preconditioning induced brain ischemic tolerance by up-regulating the expression of p-p38 MAPK protein in pyramidal neurones and astrocytes. Cases 1 and 3 received adjuvant radiation prior to implantation. Serum ET-1 is higher in subjects with hypertension, hyperglycemia, central obesity or MetS. Size-Dependent Biodistribution of lodinated Oil Nanoemulsions Observed by Dual-Modal Imaging in Rats. This study compares consenting practice amongst different grade of surgeons for Laparoscopic Cholecystectomy (LC) with specific reference to the documentation of the complications of surgery. Plant-parasitic nematodes are primary biotic factors limiting the crop production.

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Whether official positive and negative-lists could be an appropriate instrument to give guidance to patients and physicians, should be examined. Active site structure of methylamine dehydrogenase: hydrazines identify C6 as the reactive site of the tryptophan-derived quinone cofactor. The authors describe a study done to evaluate the implementation of a home health agency-based hospice program. The remarkable success of immune therapies emphasizes the need for immune-competent cancer models. Recent discovery of non-coding microRNAs (miRNAs) has prompted extensive research in understanding the roles of these molecules in skeletal muscle. CGRP content was increased in the medulla oblongata and followed a comparable time course but, unlike SP, was not altered in the hypothalamus or midbrain. In vitro characterization of noradrenergic modulation of chemosensitive neurons in the retrotrapezoid nucleus.

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The crystal structure of APAP-TMG revealed that it was a cocrystal, since no proton was transferred between the APAP and TMG molecules. DNA analysis was performed by the method of Southern using probes for the Ig JH, TCR-C beta 1, and TCR-J tau 1 regions. The PBMC levels of patients with migraine, but not other commonly seen headache types, exhibited a significant reduction in PACAP mRNA expression compared with healthy control subjects. In this study, we sought to determine the MLAD of intrathecal ropivacaine and bupivacaine for elective cesarean section and to define their relative potency ratio. Therefore, the interaction that most likely drives the dynamics of these two species in the field is exploitative resource competition. PHO13 deletion-induced transcriptional activation prevents sedoheptulose accumulation during xylose metabolism in engineered Saccharomyces cerevisiae.

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Handled properly, word processing delivers significant benefits: improved collections, increased cash flow, reduced paperwork, increased donations to healthcare foundations, improved productivity and improved document quality. Here, we report that the production of methylated bismuth species by the methanoarchaeum Methanobrevibacter smithii, a common member of the human intestine, impairs the growth of members of the beneficial intestinal microbiota at low concentrations. In parallel, slight reductions in kallikrein-like activity were observed in patients treated with aprotinin. The assessment of upper limb function and the range of severity of the lesions at the very young age are outlined. In some cases, northern blot analysis or staining with monoclonal antibodies specific for the Tla-encoded thymus leukemia (TL) antigen were used to confirm the expression pattern of several of the genes as determined by PCR. Case 2 showed a response of the toxic epidermal neurolysis (TEN) type, which could have been very severe and dangerous had the diagnosis not been made in an early stage before the development of generalized TEN. The aim of the present study was to develop a multiplex real-time RT-PCR assay, based on the TaqMan technology, for the rapid and unambiguous characterisation of all bovine pestiviruses, including the emerging HoBi-like strains. We found that virus infection induces RTL1 expression, suggesting that this enzyme could play a role in plant-virus interaction.

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Neuronal cells derived from induced pluripotent stem cells to model motoneuron diseases. Of particular interest, ctDNA was an independent predictor of survival in patients with ovarian and endometrial cancers. Subclassification of release-regulating alpha 2-autoreceptors in human brain cortex. It is characterized by orthohyperkeratosis in the horny layer and elastorrhexis in the reticular dermis. In each of these patients, a history of abdominal surgery is present. Development of behavioral and learning objectives along with learning activities and methods of evaluation are discussed. Reverse functional design of discontinuous refractive optics using an extended light source for flat illuminance distributions and high color uniformity.

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The exact interpretation of the three-dimensional OCT-A images and their clinical application are currently under clinical evaluation. Practicing IEF-PAGE of EPO: the impact of detergents and sample application methods on analytical performance in doping control. Transporter taxonomy - a comparison of different transport protein classification schemes. To investigate the exact location and position of hyaluronic acid fillers in the perioral region by ultrasound and optical coherence tomography. Targeted selection of brownfields from portfolios for sustainable regeneration: User experiences from five cases testing the Timbre Brownfield Prioritization Tool. Furthermore, the chromodomain- and SUMO E3 ligase-dependent Cbx4 activities differentially regulate proliferation, differentiation, and expression of nonepidermal genes in KCs. Phylogenetic evidence for a new species of Barbus in the Danube River basin. The purpose of this experimental study was to investigate the effect of tube tension reduction on image contrast and image quality in pediatric temporal bone computed tomography (CT).

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Sodium Bicarbonate Solution versus Chlorhexidine Mouthwash in Oral Care of Acute Leukemia Patients Undergoing Induction Chemotherapy: A Randomized Controlled Trial. Research suggests that personality pathology is shared among a considerable portion of adolescents presenting suicidal behavior. Muscle energy metabolism in severe chronic congestive heart failure--effect of treatment with enalapril. In object recognition test, rats were submitted to three or four intertrial delay conditions (1-min, 15-min and either 60-min or 24-h). The presented method performs a morphological filtering in the polar domain yielding output images less affected by artifacts (even in cases of multiple metallic objects) without causing significant smoothing of the anatomic structures, which allows a great improvement in the 3D reconstruction. It is widely acknowledged that intraguild predation (IGP) occurs frequently between species of phytoseiid mites. The IPSF activity was reasonably stable in alkaline but unstable in acidic solution and heat-unstable. From the DGGE, T-RFLP, MPN and HPLC results it was concluded that strain CY-1 effectively degraded 2,4-D without disturbing the ecosystem of soil indigenous microorganisms.

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MTT, migration, and invasion assays were performed to identify the effects of si-YKL-40 on the proliferation, migration, and invasive abilities of the HEC-1A cells. Together, these methods enable determination of an important parameter of the pregnancy phenotype. For some racemates, the amylose derivatives with different phenylcarbamate substituents at 2,6- and 3-positions exhibited higher enantioselectivity than the amylose tris(3,5-dimethylphenylcarbamate), which is commercially available as Chiralpak AD, one of the most powerful CSPs. Livers with what are the side effects of the medicine strattera moderate steatosis are currently recruited as marginal organs to face donor shortage in transplantation, even though lipid excess and oxidative stress increase preservation injury risk. hepatitis C - genotypes - prevalence - risk groups - HCV-associated diseases. Reactive oxygen species inactivate neuronal nicotinic acetylcholine receptors through a highly conserved cysteine near the intracellular mouth of the channel: implications for diseases that involve oxidative stress.

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microRNA-145 Mediates the Inhibitory Effect of Adipose Tissue-Derived Stromal Cells on Prostate Cancer. Implantable cardioverter defibrillator infection due to Mycobacterium mageritense. Gene expression of the insulin-like growth factors and their receptors in cultured human retinal pigment epithelial cells. Mason IV fractures treated with primary RHA are associated to better outcomes. These results indicated that there are marked differences in the susceptibility to 4NQO-induced tongue carcinoma among the seven strains of rats, and that Dark-Agouti and Wistar/Furth rats could be useful as models of highly and poorly susceptible strains, respectively, noroxin 400mg tablets for further genetic analysis.

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Rather, it is important to consider the impacts of differences in the semantics, affordances and functions associated with landscape features held by different groups of crowdsourced data contributors. Here, we analyzed the effects of brusatol on the cellular proteome in the KEAP1 mutant non-small cell lung cancer cell line A549. These results suggest that MIRT might slow down the progression of motor decay, it might delay the need for noroxin medicine increasing drug treatment, and thus, it might have a neuroprotective effect. In this study, the authors investigated the efficacy of alternating screening mammography and breast MRI every 6 months in women who had a genetically high risk of developing breast cancer. The technique consists of opposing two adjacent subcutaneously pedicled rectangular flaps by advancement and lengthening a contracture band. Central location of the motoneurons that supply the cucullaris (trapezius) of the clearnose skate, Raja eglanteria.

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The multi-subunit transcription/repair factor IIH (TFIIH) is an important decision maker in NER, by opening the DNA double helix after the initial damage recognition and subsequently verifying the lesion. Complete ophthalmoplegia: A rare presentation of idiopathic intracranial hypertension. The complex interplay between stress and bacterial infections in animals. Effect of Exergames on Depression: A Systematic Review and Meta-Analysis. Non-directive genetic counselling - respect for autonomy or unprofessional practice?. This pilot study examines the benefits of this simulator in a deliberate practice curriculum.

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We develop a new lysosome-targeting AIE fluorescent probe tetraphenylethene-morpholine (TPE-MPL), by incorporating a typical lysosome-targeting moiety of morpholine into a stable tetraphenylethene skeleton. A large 11-year follow-up in the general population (HUNT 2 and 3). We also mapped the receptive field dimensions of the crossed isthmotectal axons. This material exhibits time dependent multicoloured emission, part of which shows a persistent green phosphorescence visible for up to two seconds to the naked eye, which originates from multiple charge transfer mechanisms. Perioperative posterior reversible encephalopathy syndrome in 2 pediatric neurosurgery patients with brainstem ependymoma. The association between depression and loss of bone mineral density (BMD) has been reported as controversial.

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Aging-related impairment of urine-concentrating mechanisms correlates with dysregulation of adrenocortical angiotensin type 1 receptors in male Fischer rats. We report a death case of a man in his sixties with pneumocystis pneumonia during chemotherapy for gastric cancer. The system is based on complementation of niaD mutants using the nitrate reductase structural gene (niaD) of P. Effects of Task-oriented Approach on Affected Arm Function in Children with Spastic Hemiplegia Due to Cerebral Palsy. Fertility concerns in men with genitourinary malignancies: Treatment dilemmas, fertility options, and medicolegal considerations. Lymphocytic hypophysitis (LYH) is a rare neuroendocrine disorder characterized by autoimmune inflammation of the pituitary risperdal medication dosing gland. Cellular differentiation in prostatic explant cultures: assessed by electron microscopy and X-ray microanalysis. In the context of telemedicine the proposed system can be considered as a really innovative product in which all the most advanced technologies of biomedical engineering converge to guarantee an efficient and reliable home assistance that allows the patient a highly better quality of life in terms of prophylaxis, treatment and reduction of discomfort connected to periodic patient controls and/or hospitalization.

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Lipoxygenase products consisted mainly of 15-hydroxyeicosatetraenoic acid (15-HETE), accompanied by the 15-hydroperoxy analog (15-HPETE) and the 5-HETE product. We compared the results of stented and stentless LP procedures performed at two centers. The inhibitory potency varies depending on the structure of sugar. The arbitrary division of the skin paddle into zones based on relative perfusion has simplified an appreciation of the underlying vascular anatomy. Associations of platelet-activating factor acetylhydrolase (PAF-AH) gene polymorphisms with circulating PAF-AH levels and risk of coronary heart disease or blood stasis syndrome in the Chinese Han population.

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Here, we show that a branched-chain C-20 polyunsaturated fatty acid, geranylgeranoic acid (GGA), induces upregulation of the cellular protein levels of TP53-induced glycolysis and apoptosis regulator (TIGAR) and synthesis of cytochrome c oxidase 2 (SCO2) in human hepatoma-derived HuH-7cells harboring the mutant TP53 gene, suggesting that GGA may shift an energetic state of the tumor cells from aerobic glycolysis to mitochondrial respiration. Epitope localization reacting with mice monoclonal antibodies (Mabs) H 4 was investigated using the specimen of epithelium of skin, human uterine cervix as well as in the culture of epithelium cells of guinea-pig duct deferent. In the 16 keloids treated with 2 fractions, there was no evidence of recurrence. This step is essential for microspore development and pollen wall maturation. We also highlight a critical and poorly understood problem for vaccine selection by revealing qualitative differences between assays that are often used interchangeably to determine antigenic match between field viruses and vaccine strains. Occupational licensure and the utilization of nursing labor: an economic analysis. Indirect costs associated with glioblastoma: Experience at one hospital. IGU can be used in wide variety of situation of the treatment of rheumatoid arthritis and it is desired that after the all-case surveillance condition for approval, IGU become a standard csDMARDs all over the world which was made in Japan.

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