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Actos (Pioglitazone)

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Actos is a diabetes drug prescribed alongside diet and exercise to control blood sugar levels in people with Type 2 diabetes. A thiazolidinedione, or glitazone, Actos may be used alone or with other diabetes drugs.

Other names for this medication:
Accuglim, Amaryl, Asoride, Daoride, Diamet, Diavista, Diazero, Dibiglim, Dimbest, Geoglit, Glime, Glimestar, Glimiprex, Glimitab, Glita, Glitafor, Glitter, Glucut, Glufit, Glycinova, Glyciphage, Glycirest, Matce, Metanorm, Metme, Mopaday, Nodiab, Pianorm, Pichromet, Piocon, Piodart, Pioglar, Pioglitazone, Pioglu, Piolet, Pioriv, Pioryl, Piozed, Piozone, Prichek, Radizone, Triblend, Triexer, Triglaz, Triglimiprex, Vedapride, Zogli, Zorep

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Also known as: Pioglitazone


You should take Actos according to your doctor’s or healthcare provider’s instructions.

Actos comes as a tablet that you swallow.

When to take

You’ll take Actos once a day. Try to take this medication at about the same time each day.

Don’t take more than one dose in a day.

To help make sure that you don’t miss a dose, try setting a reminder on your phone. A medication timer may be useful, too.

Taking Actos with food

You can take Actos tablets with or without food.

Can Actos be crushed, split, or chewed?

No, you shouldn’t break, crush, split, or chew Actos tablets. Broken tablets haven’t been studied, so it’s not known if it’s safe to take a tablet that’s broken.

If you’re having trouble swallowing your Actos tablets, talk with your doctor. They may be able to suggest ways to help you take your medication or recommend other drugs that may be easier for you to take.


Usual Adult Dose for Diabetes Type 2:

-Patients without congestive heart failure: Initial dose: 15 mg or 30 mg orally once a day -Patients with congestive heart failure (New York Heart Association [NYHA] Class I or II): Initial dose: 15 mg orally once a day Maintenance dose: 15 mg to 45 mg orally once a day based on glycemic response as determined by HbA1c Maximum dose: 45 mg orally once a day Comments: -This drug exerts its antihyperglycemic effect only in the presence of endogenous insulin and therefore is not expected to be effective in patients with type 1 diabetes mellitus or diabetic ketoacidosis. -Patients concomitantly receiving an insulin secretagogue or insulin may need to reduce the dose of the insulin secretagogue or insulin if hypoglycemia occurs. Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus in multiple clinical settings

Detailed Actos dosage information


If an overdose occurs and you are not feeling well, you should seek emergency medical attention or contact your health care provider immediately. You can experience the following symptoms of Actos overdose: signs of low blood sugar, such as extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Actos are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Actos can interact with several other medications. It’s not known to interact with supplements or foods.

Different interactions can cause different effects. For instance, some interactions can interfere with how well a drug works. Other interactions can increase the number of side effects or make them more severe.

Actos and other medications

Below is a list of medications that can interact with Actos. This list doesn’t contain all drugs that may interact with Actos.

Before taking Actos, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

Actos and other diabetes medications

Sometimes your doctor may prescribe Actos along with other medications for your type 2 diabetes, such as glyburide (DiaBeta) or insulin. However, this may put you at risk for developing hypoglycemia (low blood sugar).

Hypoglycemia can cause symptoms such as dizziness, sweating, and headache. In severe cases, you may have serious complications such as a seizure or passing out.

Before starting Actos treatment, it’s important to tell your doctor what other medications you’re taking.

You should also talk with your doctor about what to do if you develop symptoms of hypoglycemia, especially if you’re taking multiple diabetes medications.

Actos and gemfibrozil

Gemfibrozil (Lopid) may interact with Actos. If you’re taking gemfibrozil, the level of Actos in your body will rise. Gemfibrozil can also increase the amount of time that Actos stays in your body.

If there’s too much Actos in your body and you’re also taking other diabetes medications such as insulin, your blood sugar can get too low. This can cause symptoms such as dizziness or sweating.

Before you start taking Actos, have your doctor review your all medications. They can adjust your treatment as needed.

Actos and rifampin

Taking rifampin (Rimactane) along with Actos may decrease the level of Actos in your body. This means that you may not get enough Actos, and it may not work to treat your type 2 diabetes.

If you start or stop taking rifampin while using Actos, your doctor may need to change your dose of Actos.

Actos and topiramate

If you take Actos along with topiramate (Topamax, Trokendi XR, Qudexy XR), the level of Actos in your body may decrease. This means that the Actos may not work well to treat your type 2 diabetes.

If you’re taking topiramate and Actos, talk with your doctor. They may recommend changing your dose of Actos or monitoring your blood glucose more often to be sure that Actos is working for you.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Actos and herbs and supplements

There aren’t any herbs or supplements that have been specifically reported to interact with Actos. However, you should still check with your doctor or pharmacist before using any of these products while taking Actos.

Actos and foods

There aren’t any foods that have been specifically reported to interact with Actos. If you have any questions about eating certain foods with Actos, talk with your doctor.

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