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Adalate (Nifedipine)

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Adalate is used to treat high blood pressure or angina (chest pain). For high blood pressure: Adalate works by relaxing and expanding the blood vessels. This makes the blood flow more easily and lowers blood pressure. Lower blood pressure reduces the strain on your heart. For angina: Adalate works by relaxing and expanding the arteries supplying the heart. This allows more blood and oxygen to reach the heart and decreases the strain on it. Your angina attacks will be less severe and less frequent if there is less strain on the heart.

Other names for this medication:
Adefin, Adipine, Amarkor, Atanaal, Bresben, Calchan, Cardiosol, Carditas, Chronadalate, Cisday, Conetrin, Coracten, Cordaflex, Depicor, Duranifin, Fedip, Fenidina, Ficor, Hexadilat, Jutadilat, Myogard, Nefelid, Nelapine, Nicardia, Nidicard, Nidilat, Nifecardia, Nifed, Nifedalat, Nifedate, Nifediac, Nifedical, Nifedicor, Nifehexal, Nifelong, Nifestad, Nipidin, Nipin, Ospocard, Sepamit, Siopelmin, Tenif, Tensopin, Valni

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Also known as: Nifedipine


Nifedipine is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Nifedipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, nifedipine relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain nifedipine. It may not be specific to Adalate XL. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended release tablet whole. Do not break, crush, or chew it. It is best to take this tablet on an empty stomach.

If you are taking the extended-release tablets, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of chest pain or high blood pressure: For oral dosage form (capsules): Adults—At first, 10 milligrams (mg) three times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 30 or 60 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 90 mg once a day. Children—Use and dose must be determined by your doctor.


If you overdose Adalate and you don't feel good you should visit your doctor or health care provider immediately.


Store at room temperature between 15 and 25 degrees C (59 and 77 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Adalate are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies have not been performed on the relationship of age to the effects of nifedipine in the pediatric population. Safety and efficacy have not been established.

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Profiles of metabolic control in diabetic children-frequency of asymptomatic nocturnal hypoglycemia. This class of suppressors phenotypically suppresses all known export-defective mutations, internal to the signal sequence region of the lamB gene. An advantage of the proposed method is that it can classify the type of contaminant in minutes with no significant compromise on true positive rate. From a methodological perspective, our work highlights that SDMs are a useful tool for assessing impacts of climate change on biodiversity. The main symptoms of this disease such as abdominal pain, renal failure or pulmonary hypertension and even the basis of the dramatic thrombophilia can be related to intravascular haemolysis and liberation of free haemoglobin resulting in NO depletion. ANMCO/SIC Consensus Document: cardiology networks for outpatient heart failure care. In the present study, evaluation of the micronuclei (MN) formation in oral mucosa cells, urothelial cells and peripheral blood lymphocytes was carried out in the symptomatic individuals exposed to arsenic through drinking water. We then tested the hypothesis that PMA and DAG function after PI3K and prior to Ras and protein kinase C (PKC) during macropinosome formation in macrophages. The upper salinity limit at which each dissimilatory process takes place is correlated with the amount of energy generated and the energetic cost of osmotic adaptation.

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Because stem cell therapy for cartilage repair in humans is at an early phase, confusion and errors are found in the literature regarding use of the term stem cell therapy in this field. The resistance level was decreased initially, recovered to normal levels, and continued to increase. Physicians should also recognize that the design of the study, in which full doses of the ACE inhibitor and the ARB were administered, might not replicate clinical practice, where one drug is usually added to the other. Genome-Nuclear Lamina Interactions Regulate Cardiac Stem Cell Lineage Restriction. Toxicity of the insecticide chlorpyrifos to the South American toad Rhinella arenarum at larval developmental stage. Understanding hesitancy, leading in some cases to refusal, is vital to the success of GPEI. Magnesium-aluminum oxide (Mg-Al oxide) obtained by thermal decomposition of Mg-Al layered double hydroxide (Mg-Al LDH) effectively removed HCl from gaseous streams.

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Pregnancy and Childbearing Among Young Adults Who Experienced Foster Care. The influence of S1P signalling on cytokine release was quantified by ELISA. Some differences between age groups in these relationships were found. epsilon-amino caproic acid, and also by desalting serum and adding MgCl2 and CaCl2. Sexual dysfunction in partners of men with premature ejaculation. To test the autonomy theory of nicotine dependence, and to evaluate the Hooked on Nicotine Checklist (HONC) as a measure of the loss of autonomy over tobacco use.

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Multiple lead and generator replacement and related complications often complicate the decision of pacemaker implantation in non-elderly patients with symptomatic bradycardia. Twenty-five adults completed a newly designed task in the four conditions above. We find a highly nonlinear dependence on the impurity polarization, including possible sign changes. In vitro effects of various metabolic inhibitors on the formation of inactive renin and the loss of renin in rabbit uterine tissue. Nestedness of mutualistic networks decreased with increasing temperature variability between years.

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ARF4 suppression in the IEC line increased the expression of tight junction proteins and decreased intestinal epithelial permeability. Italian standardization and classification of Neuropsychological tests. Factors affecting capture of Cryptolestes ferrugineus (Coleoptera: Laemophloeidae) in traps placed in stored wheat. Endosomal TLRs are expressed selectively, and predominantly by immune cell types. Thrombocytopenia in children can be classified on the basis of understanding of the production, life span, and fate of platelets. Mitochondrial trafficking in the distal neuronal processes declines progressively with age starting from early adulthood. Overall, the author likes receiving care from individuals from other countries, finding reward in comparing how her personal struggle with illness and paralysis resonates with the trauma of migration and how learning firsthand about varying beliefs and attitudes clarifies her identity and place in world history. Managing atopic eczema represents one of the most challenging aspects of dermatology nursing, especially in children. Furthermore, developing an action plan for managing a health workforce is emphasised and a reviewing and monitoring process to guide corrective actions is suggested.

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Ten scenarios were developed to assess the ability of trauma teams to provide initial care to a severely injured patient. Selenocystine (SeC), a naturally occurring selenoamino acid, has been shown to be a novel compound with broad-spectrum anticancer activity. The utility of clinical ultrasonography in identifying distal forearm fractures in the pediatric emergency department. CT exhibited high diagnostic performance and very high sensitivity for cecal volvulus. High NLR is an independent poor prognostic marker in CRC and correlates with a distinct cytokine profile related to key biological processes involved in carcinogenesis.

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Palaeogeographic maps illustrate the Mesozoic Atlantic opening, the Cenozoic closure of the Tethys, the Messinian Salinity Crisis, the mid-Miocene closure of the Central American Seaway, and Quaternary geological changes. The aim of this study was to relate the type of molecular defect with clinical and hematologic features and response to splenectomy using information from a large database of patients. The facile synthesis of layered Ti2C MXene/carbon nanotube composite paper with enhanced electrochemical properties. Ischemic volume then increased from 1 to 2 days in all mice, then stabilized without further change. MicroRNAs are a class of 17-25 nucleotide non- coding RNAs that have been shown to have critical functions in a wide variety of biological processes, such as cell differentiation, cell cycle regulation, carcinogenesis, apoptosis, regulation of immunity as well as in viral infections by cleavage or translational repression of mRNAs. Sphaeropsidins D and E, two other pimarane diterpenes, produced in vitro by the plant pathogenic fungus Sphaeropsis sapinea f. Lobular breast carcinoma has a greater propensity to metastasize to the GI tract compared with other breast cancer subtypes. Selective Mutism has to be differentiated from the silent period observed in the normal successive bilingual development. Moreover, the initial energy could be trapped within a ring configuration of such dynamically controlled quantum nodes.

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Oxytocin did not induce flank marking when injected into socially naive female hamsters that were tested with an opponent or alone. From a metabolic point of view, the gut is a large metabolic organ and one of the first to come into contact with dietary fats. Effects of empathic social responses on the emotions of the recipient. Gotzsche, in Lancet Psychiatry, argued that antidepressants produce more harm than good and should be used sparingly. In this study, we purified nuclear lamins from rainbow trout erythrocytes, raised an anti-lamin monoclonal antibody (L-200) that recognizes goldfish somatic-lamins, and isolated cDNAs encoding goldfish B-type lamins (B1 and B2) from a goldfish cell culture cDNA library. The non-specific clinical presentation, the rapid deterioration and incidentally the fatal outcome all underline the importance of recognition and knowledge of this genetic disorder.

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Despite evidence of immunogenicity, redosing with either WF or porcine hepatocytes resulted in no overt toxicity. To evaluate the effect of electro-acupuncture on Zusanli (ST 36), Guanyuan (RN 4) in patients with sepsis, and explore its mechanism in term of immune regulation. A Phase II Study of Sequential Capecitabine Plus Oxaliplatin Followed by Docetaxel Plus Capecitabine in Patients With Unresectable Gastric Adenocarcinoma: The TCOG 3211 Clinical Trial. This study was designed to determine the clinical characteristics and verify the results of surgical treatment for non-small cell lung cancer (NSCLC) in patients with hepatocellular carcinoma (HCC), from the results of retrospective analysis of the cases. Gastric fistula closure after EFTR is a challenge for endoscopists.

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Although severe complications are uncommon, in recent years several cases of oral squamous cell carcinoma adjacent to dental implants have been published. A comparison of diuretic pastillas arcoxia 120 mg para que son induced potassium losses in normal and abnormal subjects. Over the last few years, the hyphenation of ion mobility spectrometry to mass spectrometry or liquid chromatography with mass spectrometry has attracted more and more interest, with significant progresses in both technical advances and pioneering applications. Ischemic preconditioning improves mitochondrial tolerance to experimental calcium overload. Patient accountability was facilitated by setting patient-centered goals for knowledge and skills. The government invited the local production of medical substances, whereas pharmaceutical businesses replaced imported medical substances with locally produced antibiotics. Conserved hydrogen bonding in tetrahydrocarbazolone derivatives: influence of solution-state assembly on crystal form nucleation. The Ni(111) lattice is treated rigidly, classically, and quantum mechanically so as to reveal the effect of lattice motion.

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Isorhamnetin and Quercetin Derivatives as vasotec class drug Anti-Acetylcholinesterase Principles of Marigold (Calendula officinalis) Flowers and Preparations. Based on this evidence, in other instances HP could be judged circumstantial rather than fatal. Identifying functionally coexpressed genes and modules has increasingly become important to understand the transcriptional flux and to understand large scale gene association. A new method for DNA isolation from Prototheca algae is described. This monograph has considered the clinical features, differential diagnosis, diagnostic approaches, treatment and prognosis for primary and secondary tumors of the uveal tract.

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Non-motor symptoms in patients with hereditary spastic paraplegia caused by SPG4 mutations. Rapid (5-16 sec) intravenous infusions of cocaine induced robust psychomotor sensitization at all doses tested (0.5-2.0 mg/kg). Influence of uncertainty inherent to heavy metal build-up and wash-off on stormwater quality. Glycosyl hydrolases, bacteriocins and proteases vary considerably on all replicons while two exopolysaccharide clusters and several clustered regularly interspaced short palindromic celexa drug tier repeats-associated systems show a lot of variation on the chromosome. The clinical improvement was accompanied by corresponding histological changes. This article reviews the research advances in the influence of lncRNAs on liver diseases and related mechanisms.

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Participants also completed a list of adjectives related to the frequency at which they generally experience (uncontextualized) guilt and shame (PFQ-2). Eight rabbits survived the infection for 10 days and were killed after four of them, infected with 100 to 10 000 haemagglutination units, had started to develop progressive jaundice. The complex network of AECOPD- or COPD-specific immunomodulatory mediators will benefit the development of precision or personalized medicine strategies for prevention and treatment of AECOPD. Lexical access in a bilingual speaker with dementia: Changes over time. In this study, the alterations of the morphology and biomechanical properties of living SMCC-7721 cancer cells treated with fullerenol (C60(OH)24) for 24, 48, and 72h were investigated using an atomic force microscope (AFM). A Factor Analysis of Learning Data and Selected Ability Test Scores. Comparison of fluorescent-antibody, neutralizing-antibody, and complement-enhanced neutralizing-antibody assays for detection of serum antibody to respiratory syncytial virus. In contrast, lymphocytes from patients with HCL functioned normally with respect to NIF-T production.

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Post-infarction ventricular septal defect and aneurysm formation. The introduction of an additional cDNA purification step after reverse transcription removed PCR inhibitors, making the reaction more efficient. Sandwich-structured C/C-SiC composites fabricated by electromagnetic-coupling chemical vapor infiltration. These results are discussed with respect to the amphiphilicity of the C-terminal sequence when arranged in an alpha-helix. Seroepidemiology of Toxocariasis in Children (5-15 yr Old) Referred to the Pediatric Clinic of Imam Hossein Hospital, Isfahan, Iran. Online gait event detection using a large force platform embedded in a treadmill.

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Validating the effectiveness of Clinically Oriented Physiology Teaching (COPT) in undergraduate physiology curriculum. Assessment of vehicle speeds on different categories of roadways in Ghana. We reviewed our experience with 3 operative techniques for abdominal panniculectomies to determine differences in complication rates and levels of patient satisfaction. Training shortest-path tractography: Automatic learning of spatial priors. The clinical implications are promising and should be investigated in future clinical studies. Peanut Shell-Derived Carbon Solid Acid with Large Surface Area and Its Application for the Catalytic Hydrolysis of Cyclohexyl Acetate. In this method, an epigenetic complex subunit fused with a gene coding for a fluorescent protein is stably expressed in its corresponding knockout cells.

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The plasma is zyrtec allergy medicine non drowsy renin values increased in the control animals and those given the drug. The effect of entrapment of inulin, a model medium molecular weight compound, in positively charged, multilamellar liposomes on ocular inulin absorption following instillation of single and multiple doses to the albino rabbit eye was studied. Phase III clinical trials concerning non-small-cell lung carcinoma (NSCLC) presented at the ASCO 2001. The number of deaths due to fetal malformations in some countries now approaches the number due to prematurity and it is justifiable to believe that abnormalities will soon be heading the league of causes of perinatal death. Comparative histochemical study of alkaline phosphatase in the vertebrate ovary. Sonographic modalities play key roles in antepartum surveillance.

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I have attempted to review the evidence that one or more immunopathologic mechanisms are responsible for the clinical and pathologic findings in multiple sclerosis (MS). They include PsycINFO, Medline, EMBASE, CINAHL, Scopus and Cochrane library. A case of retinoblastoma with uncommon features is reported, aiming at improving follow-up. It contains 20 atlas templates in six species, and plugins to compute coordinate transformations, display anatomical connectivity and fiducial points, and retrieve properties, descriptions, definitions and 3d reconstructions of brain regions. Noninvasive blood flow measurements by Doppler ultrasound with application to renal artery flow determination. Our experience in the application of vertical underwater traction. This new knowledge points toward an unmet need for therapies that prevent both vascular events and organ deterioration. The St Georg sledge for unicompartmental replacement of the knee. Finally, an improved vibration frequency spectra recovery method is proposed to get a guaranteed level of sparse solution when measurement results are biased. Logistic regression analyses, estimated by using a Generalized Estimation Equation Model, were used to study the association between nurse staffing and patient outcomes.

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In systematic reviews of diagnostic studies, literature search should be sufficiently comprehensive and possible impact of publication bias should be assessed. Notably, during the rocket flight the FLUMIAS microscope reveals significant alterations of the cytoskeleton related to microgravity. Women with incarcerated partners reported low rates of condom use and HIV testing combined with a lack of information about prison-related HIV risks. Contributions to the controversy on the effect of coffee and tea consumption on the human body in medical and popular scientific literature of the 18th and 19th century. Philadelphia chromosome-like acute lymphoblastic leukemia: progress in a new cancer subtype. However, in agreement with the model predictions, different anisotropic patterns of cell organization, paralleling in vivo alterations of cardiac tissue morphology, resulted in variable and novel functional responses with important implications for the initiation and maintenance of cardiac arrhythmias. Vacuolated mitochondria are present from preleptotene through pachytene. Mannoprotein of the yeast cell wall as primary receptor for the killer toxin of Saccharomyces cerevisiae strain 28.

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The understanding of the clinical manifestations in paroxysmal nocturnal haemoglobinuria (PNH) has made great progress. Logistic regression was used to model postoperative complications. This scoring will determine the targets of therapy for reduction of apolipoprotein B-containing lipoproteins. This study should prove useful in the design and development of potential novel anticancer agents. Genomic studies have revealed four distinct molecular subgroups with divergent biology and clinical behaviour. The anastomotic site was better appreciated in Group 1 in three-dimensional views. We administered the combination of paclitaxel, topotecan and carboplatin to patients with metastatic or recurrent carcinoma of the endometrium to evaluate its activity rocaltrol capsules and to define its toxicity. Systematic reporting and formal evaluation of interventions used to reduce healthcare-associated neonatal infection outbreaks is key to identifying containment strategies worldwide. A total of 13 GPs who had attained Fellowship by Assessment in the Tamar and Severn Faculties were invited to participate in a qualitative study. Given intrarenally in a dose of 1 microgram/min, PGI2 and PGE2 increased renin release.

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Hence dirofilariasis should be considered as a differential diagnosis for migratory subcutaneous swellings and conjunctival nodules in the southern belt of India. Seasonal variation of polycyclic aromatic hydrocarbons (PAHs) emissions in China. Ultrastructure of rat heart and liver after exhaustive exercise. Except for surgery in case of isolated solitary metastases, therapeutic options in patients with brain metastases of parathyroid carcinoma are currently very limited. Subset analysis revealed a small cohort of aggressive cancer (T4/N3 HPV-negative) which may benefit from from IC, although selection bias could not be ruled out. The MVista Histoplasma antibody EIA offers increased sensitivity over current antibody tests while also allowing separate detection of IgG and IgM antibodies and complementing antigen detection. Because of the elevation of the eyebrow on the flap side, three patients required a sling to the opposite eyebrow. Human embryonic (hES) stem cells are widely used as an in vitro model to understand global genetic and epigenetic changes that occur during early embryonic development. The reduction in craving when using this cognitive regulation strategy was approximately double in SD, compared to AD, for both alcohol and food cues. To reduce the off-resonance artifact in susceptibility-weighted imaging (SWI)-based MR venography (MRV) in the brain regions with severe field inhomogeneity and to reduce the signal loss in the minimum-intensity projection (mIP) display of the 3D MRV.

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