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Alfacip (Calcitriol)

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Alfacip is a man-made active form of vitamin D. Most people get enough vitamin D from exposure to the sun and from fortified food products. Vitamin D helps control parathyroid hormone and the levels of certain minerals that are needed for building and keeping strong bones.

Other names for this medication:
Actical, Admax, Alcee, Alfabond, Alfacip, Alfarich, Alphadol, Arachitol, Aristrol, Biocitral, Bonetuf, Calasto, Calbovic, Calcibest, Calcicare, Calcigra, Calcimet, Calcirol, Calcit, Calcitriol, Calcor, Calday, Caldix, Calosto, Caltive, Caltop, Calvical, Citroj, Devita, Dmcal, Ikmag, Koncal, Kurecal, Laretol, Lctrol, Osteobel, Ostonex, Politrol, Refirm, Riecal, Romical, Solbiocal, Statbone, Vezocal, Vitalpha

Similar Products:
Altace, Soma, Cardura, Plavix, Motrin, Seroquel, Imdur, Detrol, Compazine

Also known as: Calcitriol


Generic Alfacip is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Alfacip are intestine and bone. Generic Alfacip receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Alfacip may also act on the kidney and the parathyroid glands. Generic Alfacip is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Alfacip has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Alfacip, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Alfacip in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Alfacip produces other independent beneficial effects. Alfacip is also known as Calcitriol. Generic Alfacip treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Alfacip is Calcitriol. Brand name of Generic Alfacip is Alfacip.


This section provides information on the proper use of a number of products that contain vitamin d and related compounds. It may not be specific to Alfacip. Please read with care.

For use as a dietary supplement:

Do not take more than the recommended daily amount. Vitamin D is stored in the body, and taking too much over a period of time can cause poisoning and even death.

If you have any questions about this, check with your health care professional.

For individuals taking the oral liquid form of this dietary supplement:

This preparation should be taken by mouth even though it comes in a dropper bottle. This dietary supplement may be dropped directly into the mouth or mixed with cereal, fruit juice, or other food.

While you are taking alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, doxercalciferol or paricalcitol , your health care professional may want you to follow a special diet or take a calcium supplement. Be sure to follow instructions carefully. If you are already taking a calcium supplement or any medicine containing calcium, make sure your health care professional knows.

The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For alfacalcidol To treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For parenteral dosage form (injection): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 12 mcg a week. To treat diseases in which calcium is not used properly by the body: For oral dosage form (capsules): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 0.25 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day.

For calcifediol To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults, teenagers, and children over 10 years of age—At first, 300 to 350 micrograms (mcg) a week, taken in divided doses either once a day or every other day. Your doctor may change your dose if needed. Children 2 to 10 years of age—50 mcg a day. Children up to 2 years of age—20 to 50 mcg a day. To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage forms (capsules and solution): Adults, teenagers, and children—At first, 0.25 micrograms (mcg) a day. Your doctor may change your dose if needed. For parenteral dosage forms (injection): Adults and teenagers—At first, 0.5 mcg injected into a vein three times a week. Your doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For dihydrotachysterol To treat diseases in which calcium is not used properly by the body: For oral dosage forms (capsules, solution, or tablets): Adults and teenagers—At first, 100 micrograms (mcg) to 2.5 milligrams (mg) a day. Your doctor may change your dose if needed. Children—At first, 1 to 5 mg a day. Your doctor may change your dose if needed.

For doxercalciferol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—10 micrograms (mcg) three times weekly at dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For ergocalciferol The amount of vitamin D to meet normal daily recommended intakes will be different for different individuals. The following information includes only the average amounts of vitamin D. To prevent deficiency, the amount taken by mouth is based on normal daily recommended intakes: For oral dosage form (capsules): For the U.S. Adults and teenagers—5 to 10 micrograms (mcg) (200 to 400 Units) per day. Pregnant and breast-feeding females—10 mcg (400 Units) per day. Children 4 to 10 years of age—10 mcg (400 Units) per day. Children birth to 3 years of age—7.5 to 10 mcg (300 to 400 Units) per day. For Canada Adults and teenagers—2.5 to 5 mcg (100 to 200 Units) per day. Pregnant and breast-feeding females—5 to 7.5 mcg (200 to 300 Units) per day. Children 7 to 10 years of age—2.5 to 5 mcg (100 to 200 Units) per day. Children 4 to 6 years of age—5 mcg (200 Units) per day. Children birth to 3 years of age—5 to 10 mcg (200 to 400 Units) per day. To treat deficiency: Adults, teenagers, and children—Treatment dose is determined by prescriber for each individual based on severity of deficiency. To treat diseases in which calcium and phosphate are not used properly by the body: Adults and teenagers—At first, 1000 to 500,000 Units a day. The doctor may change your dose if needed. Children—At first, 1000 to 200,000 Units a day. The doctor may change your dose if needed.

For paricalcitol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—1 to 2 micrograms (mcg) one time per day or 2 to 4 mcg three times a week (not more often than every other day). The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor. For parenteral dosage form (injection): Adults—0.04 to 0.1 micrograms (mcg) per kg no more than every other day during dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.


If you overdose Generic Alfacip and you don't feel good you should visit your doctor or health care provider immediately.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Alfacip are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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HEL cells were cocultured with various doses of PF4 in either a plasma clot system for colony assay or a liquid system for tritiated thymidine incorporation. The objective of this study is to examine if endorectal magnetic resonance imaging (e-MRI) of the prostate could improve the detection of APC. New data suggest a model in which CHCHD2 performs a prosurvival function by acting as both a reactive oxygen species scavenger and BCL-XL activator. Scientists conducting microarray and other experiments use circular Venn and Euler diagrams to analyze and illustrate their results. Farrell stresses the need to get in to all the nooks and crannies and discusses the dangers of mixing cleaning compounds as though you were pouring a Bacardi and Coke. The data fit nicely to a kinetic model that assumes first-order kinetics.

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We conducted a three-phase control program in Tumbes, Peru, to determine whether regional elimination would be feasible. Biomedical infertility care in sub-Saharan Africa: a social science-- review of current practices, experiences and view points. FPG and hemoglobin A1c are not sensitive (but are highly specific) at detecting probable diabetes mellitus among Hispanics/Latinos, independent of heritage group. These data provide evidence supporting new therapies of prostate cancer bone metastasis that target direct cancer-cell-osteoblast cell-cell contact. In baseline conditions, sotalol did not modify renal function or urinary prostanoids in any of the three strains. A PCR-based method is described to facilitate the identification of DNA fragments that are highly repeated and species-specific. Dutch HLS-EU and ALL data were used to construct prediction models based on 2/3 of this data, which were validated in the remaining 1/3 of the data and (in case of self-assessed health literacy) in data from seven other European countries. Based on literature review, there has been an increase in reported incidents of pulmonary talcosis due to various forms of exposure to the mineral. A molecular understanding of how this membrane is shaped is missing to a large extent.

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To determine the efficacy of bimanual microincision cataract surgery (B-MICS) performed by surgeons in training, evaluating clinical results, posterior capsule opacification (PCO) incidence, and clear corneal incision (CCI) architecture in a long-term follow-up and comparing results with those obtained by experienced surgeons. Gold sodium thiomalate inhibits the activity of T cell protein kinase C. Granulomatous dermatitis has been associated with hematologic disorders, including the myelodysplastic syndromes. Comorbidities are rarely taken into account in studies of neurological conditions although they may be a confounder of the outcome and treatment. Two of the siblings also had mental retardation, which is not a constant finding in Usher syndrome. Risk of developing cytomegalovirus retinitis in persons infected with the human immunodeficiency virus. Regional distribution of glutamate and aspartate in adult and old human brain. Stronger enhancer II/core promoter activities of hepatitis B virus isolates of B2 subgenotype than those of C2 subgenotype. A better understanding of the mechanism of glioma angiogenesis and invasion will lead to the development of new treatment methods.

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Conceptualization of a Health Care Coalition Framework in Georgia Based on the Existing Regional Coordinating Hospital Infrastructure. An investigation of cardiovascular reflexes during a trimix saturation dive to 450 msw (GUSI 17). Diverse microbial groups including 10 bacterial phyla, archaea and algae were found to putatively participate in the surface-colonizing process. Prevalence of HIV and HCV infections in patients receiving methadone maintenance treatment in Kaiyuan, Yunnan. In the absence of selection pressure these high-producing strains segregate to lower-producing strains by chromosome losses in the course of slant-to-slant transfers. Gerald M Reaven: good news for patients with familial hypercholesterolaemia: statins are not diabetogenic in this disease. Few studies have reported long-term data on mortality rates for children admitted to hospital with pneumonia in Africa. The ketamine model for schizophrenia has led to several therapeutic strategies for enhancing N-methyl d-aspartate (NMDA) receptor activity, including agonists directed at the glycine receptor site and inhibitors of glycine reuptake. An elliptical fenestra perforates the obturator process, and the distal end of the shaft forms an axehead-shaped expansion. Functional gonadotroph adenomas (FGAs) are rare tumors of the pituitary gland that secrete biologically active gonadotropins.

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Enantioselectivity of microsomal and cytosolic esterases in rat intestinal mucosa. Based on the difference in immersion heats, a methodology for the determination of the number of silanols on the surface is presented. The fall in catalase activity correlated well with tumor stage according to Dukes, suggesting that this peroxisomal enzyme could be used as a potential prognostic marker. c-Kit-kinase induces a cascade of protein tyrosine phosphorylation in normal human melanocytes in response to mast cell growth factor and stimulates mitogen-activated protein kinase but is down-regulated in melanomas. Silicon nanowires are widely used as active functional elements in advanced electronic devices, most notably in biological sensors. Escherichia coli is a model prokaryote, an important pathogen, and a key organism for industrial biotechnology.

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Corticosteroids and pentoxifylline for the treatment of alcoholic hepatitis: Current status. The arginine vasopressin-like protein (Avpl, formerly called Vasotocin) is a peptide hormone expressed in and around the SCN. Fracture of the acetabular cup as an early complication of total hip replacement. Although its biological importance is appreciated, very little is known about the genome dimerization process. Furthermore, co-immunoprecipitation (Co-IP) results showed that SUMOylation level of AR was decreased after cadmium treatment. The analysis also traces physician supply induced changes in the input mix used to produce visits. The global role of kidney transplantation for the world kidney day steering committee 2012. Seventy-nine patients with metastatic NETs (42 midgut, 5 unknown primary, 19 pancreatic, 13 bronchopulmonary) had blood samples drawn for CTC isolation and enumeration utilizing the CellSearch platform. (3) ET-1 was detected by immunoelectron microscopy in the lysosome, cell surface, and extracellular matrix, suggesting that lysosome possibly plays an important role in the processing of ET-1 in HUVEC. Amiloride modulates alternative splicing in leukemic cells and resensitizes Bcr-AblT315I mutant cells to imatinib.

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The effect of chronic cadmium toxicity on blood pressure and plasma viscosity. Full implementation of targeted therapy is precluded by a lack of reliable predictors of efficacy of a number of targeted drugs. This attribute has been used to develop extinction-based therapies to treat anxiety and post-traumatic stress disorders. We undertook this study to compare the probability of developing ocular trauma-related visual deficiency between genders, as estimated by the ocular trauma score (OTS). The introduced index is applied to evaluate the quality of hierarchical clustering procedures for 5-HT1A receptor ligands. These effects are contributory factors to the reduced fertility of cryopreserved spermatozoa. The staining intensity for tenascin was higher in zones along the cementum and bone surfaces. The purpose of this study is to investigate whether high-intensity focused ultrasound (HIFU) exposure is able to produce a fistula between the bladder and abdominal wall of a fetus with lower urinary tract obstruction (LUTO). Presence of these specific sites in the pyrazine imprinted system and lack of the analogous sites in the pyrimidine imprinted system is directly linked to the complexation processes in the pre-polymerization solution.

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Successful resection of an undifferentiated sarcoma in a child using a real-time surgical navigation system in an open magnetic resonance imaging operation room. Therefore, we aimed to thoroughly evaluate the efficacy and tolerability of verapamil add-on treatment. Design and optimization of four multiplex groups targeting 14 genes and their alleles on the KIR locus has been completed. These agents may be administered in the outpatient setting, thus AML in older patients is increasingly becoming an outpatient diagnosis. The purpose of this review is to discuss management issues related to the treatment of ovarian cancer, with a focus on the utilization of bevacizumab, summarizing applicable clinical trials, its potential benefits, and reported adverse events. For the inj amiodarone pediatric dose rational design of disinfection strategies, it is of utmost importance to understand the mechanisms of action of antimicrobials. This article will briefly introduce some of the issues facing EMS that will impact the future of this crucial system in New Zealand.

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T2D outcomes defined as the first diagnosis of T2D and cardiovascular outcomes defined as first diagnosis of either ischemic heart disease or stroke (ischemic and hemorrhagic stroke). Here, we assessed the genetic diversity, genetic structure and demographic history of this species. As the undergraduate medical curriculum is developed in response to an increasing number of students across multiple teaching sites, it is timely to review the clinical learning environment of medical students in the first two clinical years. While significant clinical improvements were achieved with both weighted and un-weighted solo pendulum exercises, no significant difference was detected for ultrasonographic AHD measurements between exercise groups. The FGFR2 gene in UACC812/LR was highly amplified, accompanied by overexpression of FGFR2 and reduced expression of HER2, and a cell proliferation assay showed that the IC(50) of PD173074, a small-molecule inhibitor of FGFR tyrosine kinase, was 10,000 times lower in UACC812/LR than in the parent cells. We included randomized controlled trials (RCTs) and quasi-randomized controlled trials (quasi-RCTs) on air and saline in the loss of resistance technique for identification of the epidural space.

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Integrated with a rudimentary machine-learning algorithm, the enumerator has the ability to assemble biased virtual libraries enriched in compounds predicted to meet target criteria. Most segments of the RMD curriculum are now based on interprofessional classes. TaqI polymorphism at the alanine:glyoxylate aminotransferase (AGXT) gene locus. A sample of 241 nondemented persons over the age of 65 for whom APOE genotyping was available were administered a range of neuropsychological tests at baseline and were followed up 10 years later. Synthesis of sugars embodying conjugated carbonyl systems and related triazole derivatives from carboxymethyl glycoside lactones. Patients with borderline resectable pancreatic ductal adenocarcinoma (PDA) represent a high-risk group of patients due to tumor or patient-related characteristics. The effects of N-methyl-D-aspartic acid (NMDA) and phencyclidine (PCP) on extracellular levels of dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) in the striatum of the rat were studied using in vivo microdialysis. Diets high in potassium or with a relative abundance of potassium compared with animal protein could represent a means of stone prevention.

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Summary of: Sealing ability of mineral trioxide aggregate, glass ionomer cement and composite resin when repairing large furcal perforations. However, it suffers from a lack of standardization and often produces subjective/vague diagnoses. Pregnenolone improved functional capacity in participants with schizophrenia, but did not improve cognitive symptoms over an 8-week treatment period. This methodology provides a foundation to prepare analogues of trichoderin A to establish a structure-activity relationship. We advise to consider whether there has been noticeable alcohol consumption prior to each injection. Nutritional value of high fiber co-products from the copra, palm kernel, and rice industries in diets fed to pigs. Diaminodurol, potassium sulphite, quercetin and ascorbic acid potently inhibited the spasmolytic activity of nitric oxide (NO). We also assessed the protein expression levels of subunits of the respiratory chain, initiation and elongation translation factors of protein synthesis, and localization of selected mitochondrial components. The carotid arteries from rabbits that did not respond to the collar and the sham-operated carotid arteries showed an intact and normal perivascular nerve network.

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Epigenetic refers to the study of changes that influence the phenotype without causing alteration of the genotype. Comparative analysis of the diagnostic performance of adult, cercarial and egg antigens assessed by ELISA, in the diagnosis of chronic human Schistosoma mansoni infection. The extracellular matrix is rapidly emerging as a prominent contributor to various fundamental processes of tumorigenesis. In assessing quality of care in developing countries, retrospectively collected data are usually used given their availability. In mammalian and fission yeast cells, this module interacts with TRF2 and Taz1, respectively, targeting RAP1 to chromosome ends for telomere protection. Separate regression analysis can succeed to detect divergences of climate distribution patterns of C4 taxa at global scale. The v-erbA oncogene requires cooperation with tyrosine kinases to arrest erythroid differentiation induced by ligand-activated endogenous c-erbA and retinoic acid receptor. Iron deficiency is one of the most common nutritional deficiencies worldwide. Prevention must include the nontrauma centers where many patients seek care. noroxin generic name The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region.

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Data were collected using the pretested structured questionnaire for organization commitment (OC), job satisfiers, and intrinsic job motivation. Importantly, canonical SecA interacted with the accessory Sec protein complex, suggesting that the biogenesis of SRRPs mediated by the accessory Sec system is linked to the canonical Sec system. The revised version of Short Form-12 Health Survey and Beck Depression Inventory were used to measure the perceived health status and depression symptoms. Ingestion of an orthodontic archwire resulting in a perforated bowel: A case report. The effects of a single oral dose (100 mg) of flosequinan on systemic and regional (forearm, splanchnic and renal) vascular responses to simulated orthostatic stress (lower body negative pressure, LBNP) were investigated in nine healthy male volunteers, in a double-blind, placebo-controlled crossover study. To determine functional balance abilities of older adults with diabetes, and identify determinants of these abilities. Most excitatory synapses are located on dendritic spines, which are dynamic structures that undergo morphological changes during synapse formation and plasticity. However, the disease relevance of some animal models may be uncertain and difficulties in interpretation may occur as a consequence of immunological differences between the two species.

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