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Alpron (Alprazolam)

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Alprazolam, available under the trade name Xanax, is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder, but also in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Alpron, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Alpron is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Acalm, Aleez, Alfix, Almee, Alparazole, Alprasan, Alprosym, Altin, Alzac, Alzonex, Anxicalm, Anxyl, Ateez, Azicalm, Besquil, Betapax, Emcalm, Esteem, Golprax, Kaprolam, Luzarn, Mebaspa, Niravam, Nokzok, Parazolam, Paxor, Pifzot, Pranol, Prozam, Pyrex, Rescalm, Resta, Samitol, Samrox, Sertamax, Setlan, Silam, Sinaday, Sowel, Tagat, Tenscure, Trika, Xanti, Ziety, Zolorest, Zolran, Zopam

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Also known as: Alprazolam


Alpron is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). Alprazolam affects chemicals in the brain that may be unbalanced in people with anxiety. Alpron is used to treat anxiety disorders, panic disorders, and anxiety caused by depression.

You should not use Alpron if you have narrow-angle glaucoma, if you also take itraconazole or ketoconazole, or if you are allergic to Alpron or similar medicines (Valium, Ativan, Tranxene, and others).

Alprazolam may be habit-forming. Misuse of habit-forming medicine can cause addiction, overdose, or death.

Do not drink alcohol while taking Alpron. This medication can increase the effects of alcohol. Alprazolam may be habit-forming and should be used only by the person for whom it was prescribed. Keep the medication in a secure place where others cannot get to it.


This section provides information on the proper use of a number of products that contain alprazolam. It may not be specific to Alpron XR. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is used for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the extended-release tablet or tablet whole with a full glass of water. Do not break, crush, or chew it.

If you are using the orally disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not remove the tablets from the bottle until you are ready to take it. Place the tablet immediately on the top of your tongue. It should melt quickly and be swallowed with saliva.

If you are using the oral liquid, measure the dose with a marked measuring spoon, oral syringe, or medicine cup.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For anxiety: For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.25 to 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 4 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For panic disorder: For oral dosage form (extended-release tablets): Adults—At first, 0.5 to 1 milligram (mg) taken in the morning once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.5 mg taken in the morning once a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of alprazolam can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, and fainting.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is very important to protect the orally disintegrating tablets from moisture. Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine.

Detailed Alpron XR dosage information

Side effects

The most common side effects associated with Alpron are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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Clinicopathologic study of IgM nephropathy in children presenting with idiopathic nephrotic syndrome in Pakistan. Oxygen dependence of metabolism and cellular adaptation in vertebrate muscles: a review. Twenty-five year follow-up of childhood Wilms tumor: a report from the Childhood Cancer Survivor Study. Proteases play a key role in tumor biology, with high expression levels often correlating with poor prognosis for cancer patients - making them excellent disease markers for tumor diagnosis. This essentially model-independent formulation allows us to determine molecule counts from fluorophore blinking statistics. A large multiterminal (Type II) neurone, attaching to membranous cuticle ventral to the hind wing axillary cord, was discovered.

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The ability of the pathogen to enter and exit from different states is associated with its ability to cause persistent infection. Cholesterol reduction in single and multifactor randomized trials: relationship to CHD incidence and total mortality as found by meta analysis of twenty-two trials. The reduction of TMAMQ by serum samples is directly proportional to the consumption of oxygen and the formation of syringaldazine. This could lead to deficient serotonin access in the brain that might cause disturbances in both the serotonergic and the catecholaminergic neurotransmitter systems, since these systems are highly interconnected. Despite a protracted extraoral time, follow up clinical and radiographic assessment of the tooth indicated successful replantation. Histologically, the cells enhanced skin thickness and skin vascularization. The effect of intraperitoneally administered carnitine (10 or 100 mg/kg) on the early stage of liver regeneration after two-third hepatectomy was studied in rats with experimentally induced alloxan diabetes (60 mg/kg IV). Furthermore, the overexpression of miR-181a in the K562 cells enhanced the chemotherapeutic sensitivity of these cells to imatinib. DNA aptamers are versatile recognition elements for pharmaceutical, diagnostic, and life science applications. The enhancing domain is located between amino acids 724 and 752 of the env protein sequence.

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Cells monolayered on plastic surfaces had a higher ability to produce t-PA per unit cell compared to those grown tri-dimensionally on ceramic pieces. To analyze influenza viruses isolated in the 2008-2009 autumn-winter season, and to test sera collected in the south of Western Siberia during the beginning and the end of the epidemic seasons from 2007 until the A/H1N1 pandemic. Improvement of ethanol production using Saccharomyces cerevisiae by enhancement of biomass and nutrient supplementation. Initially, the efforts should be centered on the specific risk groups for iron deficiency anemia, i.e., young children, adolescent females, women of reproductive age, as well as pregnant women and postpartum lactating mothers. Focal extracellular recording techniques were used to study the effects of clonidine, yohimbine and tyramine on the intermittent transmitter release mechanism in the guinea-pig vas deferens in vitro.

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Intermittent bilateral superior palpebra ptosis in a 20-month-old infant. Future research in primary prevention should address concerns of high-risk groups and high-risk countries, such as lower income populations in the United States or countries that have large adolescent homeless populations. Because the rate of material released into the water column by some of the processes is not well understood or known a priori, the modeling approach was to bracket parameters within reasonable ranges to produce a suite of potential results from multiple model runs. All full families (129) and 86 CF families with a decreased index child were found to be either fully (42 per cent) or partially (40 per cent) informative for DNA analysis. Chemical composition and cytotoxicity of oils and eremophilanes derived from various parts of Eremophila mitchellii Benth. The electrocatalytic oxidation of small organic molecules, such as formic acid and methanol, also exhibited unique selectivity on the single-atom platinum catalyst.

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Results also indicate that activation energies are higher near the conduction edge, thus, implying that enhanced fission product retention can be achieved through n-type doping of 3C-SiC, which limits the availability of the migration mediating carbon vacancies. Assessing the effects of curricula change on student learning: an ethnographic methodology. BHR, which reflected reactive airways, but not lung function, was associated with respiratory allergy, namely the combination of current asthma, prolonged rhinitis and a positive SPT. Clinically, TK fusions have emerged as prime targets for therapy with small molecule kinase inhibitors. Herein, we sought to identify additional citrullinated epitopes in human PG that are recognized by T cells or antibodies from RA patients. All had histologically proven disease and had received radiotherapy.

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Treatment of prostate cancer is associated with risk and complications that negatively affect the quality of life of men with localized disease. Spontaneous closure of the fistula occurred after a three-week treatment with somatostatin. Three-year study of fast-growing trees in degraded soils amended with composts: Effects on soil fertility and productivity. Interleukin 4 amplifies monocyte chemotactic protein and interleukin 6 production by endothelial cells. Physical qualities predict change-of-direction speed but not defensive agility in Australian rules football. In this article, we report a case of 52-year-old female with a complaint of nasal obstruction along with occasional nasal bleeding for one year. Measures for emotional self-control (regulation of sadness and anger), emotional dysregulation (angerability, affective lability, and rumination about sadness or anger), and behavioral self-control (planfulness and problem solving) were obtained. Little information exists on work and stress related health of medical doctors in non-EU countries. Incorporating World Knowledge to Document Clustering via Heterogeneous Information Networks. RGB-286638 is a multitargeted inhibitor with targets comprising the family of cyclin-dependent kinases (CDK) and a range of other cancer-relevant tyrosine and serine/threonine kinases.

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Focus group discussions were held with 27 community nurses and semi-structured interviews with three managers during January-March 2009 in a purposive sample from one health board. Treating CSHCN under GA, with 3-month recall visits for the patients, had a significant long-term effect on their OHRQoL extending up to 12 months postoperatively. The newest release of the Eclipse (Varian) treatment planning system (TPS) includes an optimizing engine for Elekta volumetric-modulated arc therapy (VMAT) planning. To prepare specific antibodies against ciprofloxacin (CIP) and characterize the antibodies properities with ELISA, then lay the foundation for development of CIP rapid detection kit. The paired box gene pox neuro: a determinant of poly-innervated sense organs in Drosophila. Patients were randomly assigned into 2 groups of intervention group and control subjects. These patterns were generally robust to the choice of functional axes, though important trait-specific exceptions occurred.

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The presentation of the products and mode of action determine the regulatory demands and the approval process, as they can fall into different regulatory entities, such as cosmetics, medicinal products, medical devices and as other chemical products. We aimed to evaluate the prevalence of atherosclerosis and identify specific clinical risk factors associated with early vascular inflammation. Increased urinary neutrophil gelatinase associated lipocalin in urinary tract infections and leukocyturia. Twenty-two people with severe TBI and a familiar communication partner engaged in a 10-minute casual conversation on self-selected topics at 3 and 6 months post-injury. To determine whether the proliferation rates of tumour cells may relate to prognosis and reflect disease activity. For the subsequent 28 months she has been free of any further symptoms. Perceptual sensitivities are malleable via learning, even in adults.

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The emergence of microRNAs has been one of the defining developments in cancer biology over the past decade, and the explosion of knowledge in this area has brought forward new diagnostic and therapeutic opportunities. The usefulness of photodynamic eye for sentinel lymph node identification in patients with cervical cancer. The interaction of DNA with 5,10,15,20-tetrakis(4-N-methylpyridiniumyl)porphyrin (TMPyP) in polyelectrolyte core-shells obtained via layer by layer adsorption of poly(sodium 4-styrenesulfonate), PSS, and poly(allylamine hydrochloride), PAH, polyelectrolytes was followed by steady state, time resolved fluorescence and by Fluorescence Lifetime Imaging Microscopy (FLIM). Myostatin inhibition is a promising therapeutic approach for DMD. Severe corneal opacities hampered optic disc evaluation in the older patient with MPS VI. Anomaly detection was modeled on the modified cumulative sum algorithm implemented in the Early Aberration Reporting System.

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This chapter highlights the involvement of various mammalian ABC transporters in lipid transport in the context of their role in cell signalling, cellular homoeostasis, apoptosis and inherited disorders. The results suggest that isopropyl alcohol, potassium hydroxide, and urea as the solvent, alkalizing agent, and permeation enhancer, respectively, improved the permeation of the ciclopirox nail lacquer formulation the most with high flux rates. These results highlight the existence of a local pathway of iron recycling that plays a nonredundant role in the myogenic differentiation of muscle precursors, limiting the adipose degeneration of the tissue. Hence, CCI better reflects the burden of all combined postoperative complications in surgical patients than the Clavien-Dindo score alone, which incorporates only the most severe complication. In vitro tympanic membrane position identification with a co-axial fiber-optic otoscope. Male SD rats were divided into vehicle-treated sham, vehicle-treated SAH, and UA-treated SAH groups. Although the study of AOP is in its infancy, a deeper understanding of the central nervous system (CNS) anti-opioid systems may lead to new treatments for chronic pain, substance abuse, and psychiatric disorders.

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These results indicate that Erk5 is necessary to maintain the balance of nucleotide levels, thus preventing dNTP misincorporation and DNA damage in proliferative erythroid progenitors and leukemic Jurkat T cells. Any two cases were selected in comparison with each other among the following four cases (DTS and KUB before and after bowel preparation).The data from all cases were statistically processed by chi-square test of four-fold table. According to the results of this study, oprD mutation and AmpC overproduction can cause the main mechanism of resistance of P. Primary extraskeletal osteosarcoma of the seminal vesicle: a case report and literature review. The data indicate that MSCs transfected with HGF contribute to a reduction of renal fibrosis after ureteral obstruction and suggest that this may be exploited therapeutically. Comparative study on the acquired immunoprotection in native populations.

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Grassroots approach builds connected health community: physician retention, practice survival, quality of care fuel decision. Furthermore, transgenic Arabidopsis seeds ectopic-expressing side effects of hydrea 500 mg NnPER1 displayed enhanced tolerance to high temperature and abscisic acid (ABA), indicating that NnPER1 may participate in the thermotolerance and ABA signaling pathway. After adjustment for exercise activity, sedentary behavior appears to have an inverse association with fitness. Hematopoietic progenitor cells collected from the peripheral blood are capable of restoring hematopoiesis after myeloablative therapy. These results could provide potentially valuable information in understanding the physiological basis of the RAAS in mares, since we have been able to establish specific reference ranges for these components, as well as obtaining information on their evolution during pregnancy. Moreover, these MAbs did not react with other closely related MPT51 and MPT64 secreted proteins. Costs of staged versus simultaneous bilateral total knee arthroplasty: a population-based study of the Taiwanese National Health Insurance Database. The poor correlation between WHO clinical and immunological staging emphasizes the importance of making CD4 facilities available in HIV prevalent areas. Better, Safer Patient Care Through Evidence-Based Practice and Teamwork. It suggests that DENV-2 in mosquito cells activates the unfolded protein response to cope with endoplasmic reticular stress.

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Mice expressing the human JAK2-N542-E543del (Ex12) showed a strong increase in red blood cell parameters but normal neutrophil and platelet counts, and reduced overall survival. Our results indicated that an improved transgene expression of I-stimulated hNIS in U87-malignant glioma cells using a baculovirus vector containing the Egr1 promoter is possible, but the expression level is lower than that of Bac-CMV-hNIS- when to start diflucan after antibiotics transfected U87 cells. We tested whether these embryonic tissues change their mechanical properties in response to mechanical stimuli but found no evidence of changes in the viscoelastic properties of the tissue in response to stress or stress application rate. Developmental assets can be considered as potential health assets for adolescents. The symbiosis is established with a limited species of land plants, including legumes.

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A bovine albumin peptide as a possible trigger of insulin-dependent diabetes mellitus. This early guidance will assist the States in beginning to revise their certificate of need laws. Protective effect of baicalin against multiple ultraviolet B exposure-mediated injuries in C57BL/6 mouse skin. Comparison of palladium/zinc oxide photocatalysts prepared by different palladium doping methods for congo red degradation. Buruli ulcer (BU) disease is a chronic debilitating skin disease caused by Mycobacteriumulcerans.

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Production and characterization of two new mouse monoclonal antibodies reactive with denatured mouse class II beta chains. Subsequently, we conducted a survey of 215 healthcare workers from 25 community health centers to verify that the job description we created was accurate. Nanopharmacological Force Sensing to Reveal Allosteric Coupling in Transporter Binding Sites. The lack of industrially suitable microorganisms to convert xylose to ethanol fuel has been cited as a major technical bottleneck. The difference between cefepime and ceftriaxone in preventing SSIs following elective clean orthopedic surgery was not statistically significant. PIPmiR uses a probabilistic model that combines RNA structure and expression information to identify miRNAs with high precision. Vesicostomy might be a more favourable method due to less complication and follow-up in early neonatal life.

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It was found that, for successful source retrieval (it meant both the item and the source were remembered accurately) between 500 and 700 ms (corresponding to a late positive component, LPC), there were significant old/new effects in all contexts. Partial cardiopulmonary bypass proved to be useful for maintaining gas exchange during reconstructive surgery of the trachea. The use of the BCC strategy significantly improved the ability of mountain workers in Hainan to avoid malarial infection. From a urological point of view retroperitoneal endometriosis is a benign disease affecting the ureters and urinary bladder. Arylation and heteroarylation of thienylsulfonamides with organotrifluoroborates.

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We prospectively studied 132 patients at baseline pretransplant and at 4 weeks, 1 year, and 3 years after heart transplantation. Hairy cell leukemia is a chronic lymphoproliferative disorder characterized by the expansion of neoplastic B-cells expressing the p55 chain of the interleukin 2 receptor (IL-2R) system that is recognized by anti-CD25 monoclonal antibodies (mAb) and binds interleukin 2 (IL-2) with low affinity. Resonance Raman Optical Activity Spectra of Single-Walled Carbon Nanotube Enantiomers. This decrease in apparent viscosity was only visible at high hematocrit. We previously proposed that the disruption of dimer or oligomer formation by the C-term region allows greater can you have alcohol while on clomid chances of nucleation for aggregation. There was no significant difference in the mean melanocytic count between MART-1/Azure blue and MiTF as assessed in the solar lentigo group and as assessed independently in the MIS group. Risk and protective factors for recent alcohol use among African-American youth. These differences in cognition were not due to differential immunosuppression or to clinical status among the HIV-1-seropositives. To assess the interday reliability of peak muscular power outputs while participants performed diagonal chop and lift tests and maintained a stable trunk.

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Purification and characterization of an antihypertensive compound from Lactobacillus casei. It was suggested that the myocardial infarction was caused by thrombotic occlusion of coronary aneurysms complicated with Kawasaki disease. Chemiluminescence toxin-enhanced signal assay compensates the lack of sensitivity usually observed for EIA tests for toxins. Considering that Kampo medicine contains many plant-derived chemicals having an ability to inhibit nerve action potential conduction, it is possible that this medicine inhibits nerve conduction. A two-step PBM for estimating pharmacokinetic parameters exploited the inherent differences in pharmacokinetic characteristics associated with the TZ and PZ. The results highlighted regulated expression of serum proteins in naive patients. Hybrid vigour (heterosis) has been used for decades in crop industries, especially in the production of maize and rice.

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Phylogenetic comparison of partial nucleoprotein (N) gene sequences (737 base pairs) of the five isolates to sequences of 13 other VHSV strains showed the clustering of Diporeia spp. We show here that the non-conserved carboxy-terminal E1A exon contains two interchangeable elements that are required for efficient CR3-dependent transactivation of the adenovirus E4 promoter in HeLa cells. This critical review condenses the proceedings of a symposium at the European Society for the Biomedical Research on Alcoholism Meeting held September 12-15, 2015, tramadol hcl 50 mg tablet overdose in Valencia, Spain. Prehypertension is associated with a higher risk of incident stroke. Variation in immune function was explained when embryonic periods were corrected for average embryonic temperature, in order to better estimate intrinsic rates of development. The inhibition of pathway activity primarily impacted highly clonogenic B-ALL cells expressing aldehyde dehydrogenase (ALDH) by limiting their self-renewal potential both in vitro and in vivo.

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Steatosis is characterized by the accumulation of lipid droplets in hepatocytes. TDM35--a new monoclonal antibody to the XH1 cervical carcinoma cell line. Current methods of surgical treatment of gastroesophageal reflux. Nonmedical prescription opioid use has been linked to ramipril 10 mg twice a day hepatitis C virus (HCV) infection among people who inject drugs and with using high dead space syringes that retain more blood and transfer more HIV if shared. Anxiolytic-like actions of anpirtoline in a mouse light-dark aversion paradigm.

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