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Anxrea (Clonazepam)

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Clonazepam, sold under the brand name Klonopin among others, is a medication used to prevent and treat seizures, panic disorder, and for the movement disorder known as akathisia. It is a tranquilizer of the benzodiazepine class. It is taken by mouth. It begins having an effect within an hour and lasts between six and 12 hours. Anxrea was initially patented in 1964 and went on sale in the United States in 1975. It is available as a generic medication.

Other names for this medication:
Adnil, Calmnir, Catier, Cleps, Cloam, Clonapax, Clonapik, Clonaxyl, Clonoasig, Clonotril, Clonzy, Clopam, Cloze, Deptune, Dipwell, Easyfeel, Eminaz, Epitril, Escitrac, Ezinite, Jasoclam, Klopam, Lonazep, Melzap, Nexclo, Nozim, Onapil, Ozepam, Prasilex, Revozip, Somnolex, Somnotril, Xitzen, Zeficar, Zeptril

Similar Products:
Diovan, Cymbalta, Mellaril, Furadantin, Anafranil, Minocin, Biaxin, Zovirax, Benicar, Exelon

Also known as: Clonazepam


Anxrea results in a depression of the activities of the central nervous system. This depression is not meant to designate a feeling of depressed mood, although some people may experience depressed mood as a side effect of Anxrea use. It instead relates to a reduction in the rate of activity of the cells in the brain. This reduction in the rate of brain activity affects several cognitive functions, most notably the ability to form new memories. Memories are formed in the brain as a result of increased activity of neurons, and a person using a benzodiazepine like Anxrea will experience a dampening of these processes that can interfere with the ability to form new memories while one is taking the drug.

There is some evidence that cognitive abilities, such as memory, attention, visual spatial skills, and even intellect, might be affected as a result of long-term benzodiazepine abuse; however, the research in this area is limited due to many of the subjects in the studies having a history of abusing benzodiazepines and other substances, such as alcohol.


Take this medication by mouth as directed by your doctor, usually 2 or 3 times daily.

Dosage is based on your medical condition, age, and response to treatment. For children, the dose is also based on weight. Older adults usually start with a lower dose to decrease the risk of side effects. Do not increase your dose, take it more often, or take it for a longer time than directed.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.

Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Your dose may need to be gradually decreased.


Symptoms of clonazepam overdosage, like those produced by other CNS depressants, include somnolence, confusion, coma and diminished reflexes.

Treatment includes monitoring of respiration, pulse and blood pressure, general supportive measures and immediate gastric lavage. Intravenous fluids should be administered and an adequate airway maintained. Hypotension may be combated by the use of levarterenol or metaraminol. Dialysis is of no known value.

Flumazenil, a specific benzodiazepine-receptor antagonist, is indicated for the complete or partial reversal of the sedative effects of benzodiazepines and may be used in situations when an overdose with a benzodiazepine is known or suspected. Prior to the administration of flumazenil, necessary measures should be instituted to secure airway, ventilation and intravenous access. Flumazenil is intended as an adjunct to, not as a substitute for, proper management of benzodiazepine overdose. Patients treated with flumazenil should be monitored for resedation, respiratory depression and other residual benzodiazepine effects for an appropriate period after treatment. The prescriber should be aware of a risk of seizure in association with flumazenil treatment, particularly in long-term benzodiazepine users and in cyclic antidepressant overdose. The complete flumazenil package insert, including CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS, should be consulted prior to use.

Flumazenil is not indicated in patients with epilepsy who have been treated with benzodiazepines. Antagonism of the benzodiazepine effect in such patients may provoke seizures.

Serious sequelae are rare unless other drugs or alcohol have been taken concomitantly.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Side effects

The most common side effects associated with Anxrea are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of clonazepam in children with seizure disorders. However, safety and efficacy in children with panic disorder have not been established.

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Hospitals are challenged to implement measures to improve health outcomes, decrease costly interventions, and increase patient satisfaction. coli), is used as an indicator of microbial contamination, as high concentrations of this organism should indicate a recent fecal contamination event that may contain other, more pathogenic, bacteria. Capitalizing on the new economics: nurse executives as catalysts for action. Implementation of a sepsis management protocol incorporating evidence-based therapies can be accomplished in both academic and community hospitals, with minimal additional staffing. self-phase modulation, which, for fundamental reasons, is always accompanied by cross-phase modulation and four-wave mixing. Observation of this rare pathogen from human origin urges cautious diagnosis while attending TB cases. Additionally, the bulk of the research on outcome expectancy and treatment outcomes has relied mostly on self-report outcome measures.

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On the basis of numeral classical and recent published scientific data the problem of cellular response to stress and its possible clinical implication are presented. The aim of this study was to investigate the feasibility and effectiveness of cone-beam computed tomography (CBCT) in the planning, assessment, and follow-up for osteo-odonto-keratoprosthesis (OOKP). Of 11 studies that focused on improving self-management of T2DM, four of six tests of financial incentives demonstrated increased engagement in recommended care processes or improved biometric measures, and three of five tests of choice architecture modifications found improvements in self-management behaviors. Making evidence-based practice a reality: The National Center for Children, Families and Communities. Further, lipid composition was measured in organotypic spinal cord cultures by gas chromatography and liquid chromatography coupled to mass spectrometry. We conducted a first baseline survey in Jilin Province of China to determine the proportion of drug-resistant tuberculosis (TB), and to analyze risk factors associated with the emergence of drug-resistance. Then using CHX (cycloheximide) to prevent new protein expression in response to p53, we also find that Bax translocation and cell death by UV irradiation are delayed. Unveiling the nature of black mamba (Dendroaspis polylepis) venom through venomics and antivenom immunoprofiling: Identification of key toxin targets for antivenom development. Pathogenesis, diagnosis, and treatment of myasthenia (review of the foreign literature).

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In addition, for all protein species folding stability experiments have been carried out by monitoring the secondary structure by circular dichroism at increasing concentrations of guanidinium chloride. Effects of centrally administered endocannabinoids and opioids on orofacial pain perception in rats. Linear regression models were used to assess cross-sectional associations with plasma CRP. Efficient emission facilitated by multiple energy level transitions in uniform graphitic carbon nitride films deposited by thermal vapor condensation. Based on the literature review, we concluded that the frequency of Skene duct cyst is higher than the number of reported cases. The aim of the present study was to investigate the possible role of C-terminal domain of tetanus toxin (Hc-TeTx) on cell death mechanisms including apoptosis and autophagy following SCI. The Pedometer And Consultation Evaluation (PACE-UP) trial, a three-armed primary care pedometer-based walking intervention in those aged 45-75 years, demonstrated increased PA levels at 12 months. It may also constitute a novel approach for the treatment of cannabinoid induced memory deficits and lead to a better understanding of the brain mechanisms underlying cognition. Our findings suggest that steroid therapy and renal dysfunction affect serum MMP-3 levels in patients with RA. Furthermore, in pregnancies presenting non-immune hydrops fetalis, lysohexosylceramide measurement in amniotic fluid offers a rapid screening of fetal Gaucher disease without waiting for glucocerebrosidase activity measurement in cultured amniocytes.

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In regression analysis, the notion of population validity is of theoretical interest for describing the usefulness of the underlying regression model, whereas the presumably more important concept of population cross-validity represents the predictive effectiveness for the regression equation in future research. Affinity chromatography using competitive elution separates polyclonal glucocorticoid antisera into fractions of varying cross-reactivity. Spinal creep was measured continuously over 25 min under loaded and unloaded conditions using a seated stadiometer that controlled spinal posture. Additionally, several immunogenetic studies have identified associations between polymorphisms in genes encoding immune response proteins, both innate and adaptive, and variation in responses to vaccines. Multinomial logistic regression tested the main and moderating roles of each domain on cognition categorized as no impairment, CIND, and dementia. Interferon-alpha and ribavirin are currently the only drugs registered in the chronic hepatitis C therapy.

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Furthermore, solid tumours have been reported to secrete a diffusible factor which promotes the directional growth of new capillaries towards a growing tumour. Although the precise mechanism remains to be determined, our results suggest that constitutive NO in the coronary circulation plays an anti-ischemic role in this population. Breast cancer is the leading new cancer diagnosis in women in the United States and is the second most lethal cancer in this patient population after lung cancer. mRNA was quantified by real-time RT-PCR and protein secretion determined by ELISA. Blood, serum and urine (24-hour-samples) concentrations of cadmium, zinc, calcium and magnesium were determined by means of atomic absorption spectrophotometry in 60 patients, therefrom 30 patients with idiopathic dilated cardiomyopathy (IDC) and 30 patients with coronary heart disease (CHD). ISH was used on routine necropsic prostate epithelial samples from three patients who had died of AIDS. A method for testing the growth-promoting property of tissue culture media using radionuclides. Furthermore, since the assessment of functionality is frequently hampered by the nature of the food system, mathematical modelling techniques may help to predict the functional behaviour of novel lactic acid bacteria starter cultures in a food matrix, and hence quantify in situ production. Effect of surface organic coatings of cellulose nanocrystals on the viability of mammalian cell lines. Recent clinical studies have shown that nasogastric tube feeding is safe in the majority of patients with acute pancreatitis.

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The analysis of the main intracellular signaling pathways downstream of the activated IGF-IR, phosphatidyl inositol 3-kinase (PI3K)-Akt, and extracellular signal-regulated kinase (ERK1/2) cascades reveals that RGZ rapidly interferes with the Akt and ERK1/2 phosphorylation/activation which mediates IGF-I stimulated proliferation. The present analysis is, to our knowledge, the most complete assessment of clinical variables and their relationship to illness severity in a sample of adults with SPD. For filtering, a classifier was trained and tested on each of the following: sequences of taxa in the database, sequences of taxa related to those in the database, and random sequences. Apoptosis--new opportunities for novel therapeutics for heart diseases. Operative characteristics, transfusion rates, in-hospital outcomes as well as short and long term survival were compared between groups. In vitro degradation behaviours of organogels were investigated via two approaches in this study: a weight loss method and a drug release method. Hence, it is perhaps not surprising that the expression level of X-linked genes in female platypus is almost double that in males. Solitary fibrous is rare mesenchymal neoplasm that usually arises in the pleura or less commonly is related to other serosal surfaces. Sentinel lymph node identification and radical hysterectomy in the initial treatment of early stage cervical cancer can be performed safely by laparoscopy with lower morbidity and overall survival and recurrence-free survival similar to standard laparotomy.

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Scandinavian material is presented, consisting of 3,875 transplanted patients and containing 128 patients in whom cancer was diagnosed. The preservation of axillary lymphatic drainage after TBA allowed for SN detection in all studied breasts. Weekly dengue cases, Baidu search queries and climate factors (mean temperature, relative humidity and rainfall) during 2011-2014 in Guangdong were gathered. To evaluate the iodine nutrition of the pregnant women of the Spanish Autonomous Community Extremadura. Molecular mechanisms of placental LC-PUFA uptake and transport are not fully understood, but it has been clearly demonstrated that there is a preferential DHA transfer. Resveratrol inhibits EMMPRIN expression via P38 and ERK1/2 pathways in PMA-induced THP-1 cells. Structure analysis of polymerized phospholipid bilayer by TED and direct methods. The findings from studies on the relationship between aldehyde dehydrogenases(ALDH) gene Glu504Lys polymorphism and colorectal cancer(CRC) were inconsistent.

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However, results from 2010 indicate that cataract surgical complications still need to be focused on. Cystatin B knockdown experiments during the same treatment confirm the regulation of the nuclear activity by cystatin B. To translate, perform the cross-cultural adaptation, and an initial validation of the Brazilian Portuguese version of PedMIDAS (BP-PedMIDAS). All adults with extremity vascular injuries admitted to the Military Base Hospital Anuradhapura in an eight-month period were prospectively recorded in a data sheet and retrospectively analyzed. Extra-pituitary expressed follicle-stimulating hormone: Is it physiologically important?. Intimate partner violence and the experience of early motherhood: A cross-sectional analysis of factors associated with a poor experience of motherhood. Robust and Efficient Spin Purification for Determinantal Configuration Interaction.

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Pregnancy block in mice: changes in pituitary LH and LTH and plasma progestin levels. Changes in the Profile of Diseases Caused by the Inhalation of Silica. In selected patients, preoperative radiotherapy appears to be a good option for breast conserving therapy. Physical properties of annealed ZnO nanowire/CuSCN heterojunctions for self-powered UV photodetectors. An essential gene of Saccharomyces cerevisiae, Act3p/Arp4, encodes the first identified nuclear Arp, which has been shown to bind to core histones in vitro. The quality of reporting methods and results of cost-effectiveness analyses in Spain: a methodological systematic review. Adaptation of the STARR test for adult Italian population: A speech test for a realistic estimate in real-life listening conditions.

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According to this study, cutaneous leishmaniasis due to Leishmania tropica is endemic in the city of Yazd, Central Iran. Cycling of ribonucleic acid polymerase to produce oligonucleotides during initiation in vitro at the lac UV5 promoter. The current study examined the attentional and working memory costs of temporal integration of successive target stimulus pairs embedded in rapid serial visual presentation. Urine metal results were compared with reference values of unexposed populations to identify elevations. Concordance of Expert Consultation Diagnoses in the Review of Pelvic Washing Specimens. Double nuclear magnetic resonance observation of electron exchange between ferri- and ferrocytochrome c. Immunohistochemical reactions for CD1a and CD83 were performed in 53 patients with OSCC in tongue and floor of the mouth. However, it is controversial if mortality rate and neurologic outcome are affected by the time point of operative stabilization.

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Post-traumatic renal failure, including the use of the mobile artificial kidney. Bone mineral density (BMD) was measured by quantitative digital radiography using a Hologic 2000 plus device belonging to the third generation of densitometers based on dual-energy X-ray absorptiometry. High-throughput chromosome conformation capture techniques (e.g., Hi-C), which are originally developed for decoding the 3D structure of the chromatin, provide a great opportunity to simultaneously identify the locations of genomic rearrangements and to investigate the 3D genome organization in cancer cells. Women with FGM/C who seek therapeutic surgery should be informed about the scarcity of evidence for benefits and the potential harms of the available procedures. Preliminary findings showed reduced AMH levels at 3months postoperatively in ultrasonic energy group whereas there was no significative menopausal symptoms. Apoptosis and its receptor selective pathways during neurotoxic action of glutamate. Closing the Communal Gap: The Importance of Communal Affordances in Science Career Motivation.

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Assessment of Ketamine Binding of the Serotonin Transporter in Humans with Positron Emission Tomography. As predicted, the 86.5-kDa mvaE gene product catalyzed both the acetoacetyl-CoA thiolase and HMG-CoA reductase reactions. Submucosal tumors were classified as SM1, SM2, and SM3 according to the depth of invasion. Restorations for bottle-mouth syndrome and fractured anterior teeth. Overall, despite its reputation as a mammalian gastrointestinal tract specialist, the intra-specific variation of L. The mutation is predicted to change an invariant amino acid in a highly conserved transmembrane helix of the mature polypeptide and was heteroplasmic in both skeletal muscle and cultured skin fibroblasts. Postures and movements were continuously measured over an 8 h shift using inclinometers. Staging, classification and end results for carcinoma of the thyroid. Proposed changes of procedure in studies on Salmonella and Shigella carrier states. Pressor and intestinal vascular bed responses to vasopressin after cholinergic blockade.

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Obesity is related to obstructive sleep apnea-hypopnea syndrome (OSAHS), but its roles in OSAHS as cause or consequence are not fully clarified. The prediction of the protein tertiary structure from solely its residue sequence (the so called Protein Folding Problem) is one of the most challenging problems in Structural Bioinformatics. Therefore, the data-driven mechanism is designed for obtaining better control parameters to ensure good performance on numerical benchmark problems. Fgf signaling in the zebrafish adult brain: association of Fgf activity with ventricular zones but not cell proliferation. Effect of leucogenenol on antibody formation in the irradiated mouse. Seven RCTs with 452 participants (227 patients and 225 controls) were included in the meta-analysis. We review some of these findings and discuss their functional implications. Next, we detail the construction of a microfluidic flow cell to image immobilized proteoliposomes on a total internal reflection fluorescence microscope. Oncological effectiveness of ablative techniques is encouraging as 3-year data are emerging.

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Spectroscopic insights into quadruplexes of five-repeat telomere DNA sequences upon G-block damage. However, we find very different predictions for combinations, where flux diversion, which mimics the kinetics of competitive metabolic inhibitors, can explain serial target synergies between metabolic enzyme inhibitors that we confirmed in Escherichia coli cultures. In addition, the interaction between GraS and noroxin dosage GraR is very weak in comparison to the stronger interaction observed between BceS and its conjugated response regulator, BceR, suggesting that CAMP signaling may not flow directly from GraS to GraR. It will be our continuing thesis that the current infection control practitioner and hospital epidemiologist will need to become more involved in the quality assurance and risk management activities of their institutions and that training in all fields of medical care evaluation will need to be founded in epidemiology. Adult eating disorder patients have been characterised by alexithymia.

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Antiproliferative Effects of New Dimeric Ellagitannin from Cornus alba in Prostate Cancer Cells Including Apoptosis-Related S-Phase Arrest. This article presents the important anatomic features of the shoulder joint and the abnormalities to which the athlete is most susceptible leading to pain and disability. Recurrent molecular deletion of the 12p13 region, centromeric to ETV6/TEL, in T-cell prolymphocytic leukemia. We explored the role of CDS in detecting flares and demonstrated a relationship to the extent of the distribution of halos, but not to their size. Peak intraepithelial infiltration of neutrophils was evident 6 hours after instillation. Patients with a postoperative range from 4 to 25 years were selected. Laboratory Studies of Nonlinear Optical Signals for Caries Detection. Based on the identified factors, the authors formulated recommendations for working with the first detected IPTB patients at risk for a poor disease outcome.

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Serum ANGPTL6 levels were significantly higher in type 2 diabetic patients in comparison with healthy controls. Future investigation will need to determine the biological importance of lipoprotein ceramides with distinct C-chains at amide residues. Inhibition of EVT cell migration by TGF-beta has been suggested to be due to singulair medication other names upregulation of integrins, which make the cells more adhesive to the ECM. The present review article aims to summarize the existing knowledge as to the implications of ATX in chronic inflammatory diseases and cancer and to highlight the low molecular weight compounds, which have been developed as leads for the discovery of novel medicines to treat inflammatory diseases and cancer. BoNT/B successfully reduces sweat production in individuals with residual limb hyperhidrosis, but does not affect pain. Delayed gastrointestinal symptomatology related to the process of cytotoxic treatment-induced mucosal damage needs to be better understood in order to enable the clinician to assess gastrointestinal mucosal damage properly by documenting symptomatology, testing functionality and visualizing anatomical changes. The incidence and severity of atherosclerosis is increased in patients with diabetes.

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There is also a clear need for greater focus on bereaved and young adult offspring and those from non-western cultural groups, who remain under-represented in research conducted to date. Effects of Intrauterine Growth Restriction During Late Pregnancy on the Development of the Ovine Fetal Thymus and the T-Lymphocyte Subpopulation. We performed a retrospective review of consecutive adults diagnosed para que sirve el glucophage xr 500 mg with PRES between 2000 and 2010. However, the model presented in this paper needs further theoretical and empirical elaboration and clarification of several conceptual and practical challenges. When hypertensive participants were excluded, the effect of prefrontal shrinkage on executive aspects of performance was no longer significant, but the effect of working memory remained.

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Aiming to join efforts in translating tolDC and other tolerogenic cellular products (e.g., Tregs and macrophages) to the clinic, a European COST (European Cooperation in Science and Technology) network has been initiated-A FACTT (action to focus and accelerate cell-based tolerance-inducing therapies). Several test substances proved to be as potent as INH, but their antimycobacterial spectra were broader than that of INH. This fits with earlier studies showing the later rise in expression of FSH mRNA. Total of 456 patients with center-involved diabetic macular edema (DME). A comparative study of P32 uptake by whole animals and isolated body regions of the sea cucumber Holothuria atra. ATRA induced the differentiation of APL cell lines NB4 and HT93 and APL cells in primary culture, and this differentiation was also enhanced by tamoxifen. These abnormalities may be precursors of hepatic iron overload and chronic liver damage.

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Their postoperative recoveries were uncomplicated and each was symptomatically improved. The results were compared with cytologic diagnosis, surgical pathology diagnosis, or benign clinical follow-up of at least 1 year. Beta-adrenoceptor (betaAR) density has previously been found altered in brain cortex of aging mice. Adherence of the fungus to the superficial cells of the oral mucosa appeared to involve intimate contact between the epithelial cell surface and the deeper layers tenormin atenolol dosage of the fungal cell wall. Clinical responses of sclerotic skin to UV-A1 phototherapy were modest because of UV-A1-induced skin darkening, which is photoprotective and attenuates antifibrotic responses. By the use of pharmacogenetic typing, one of the subjects was found to have a slow metabolism for CYP2C9 as well as for CYP2C19. Our data indicate that mitochondria within individual cells are morphologically heterogeneous and unconnected, allowing them to have distinct functional properties. Longitudinal changes in brain magnetic resonance imaging findings in children with sickle cell disease. This review focuses on available methodologies to study vaginal drug permeation discussing their advantages and drawbacks. The risk of bias was assessed using the Cochrane risk-of-bias tool.

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Food intake is guided by homeostatic needs and by the reward value of food, yet the exact relation between the two remains unclear. The amines differ in the extent to which they give rise to N-nitroso compounds. Mandibular advancement device was effective in decreasing respiratory events in UARS patients. Sera from human toxocariasis patients showed heterogenous WB ultram tablet band patterns similar to those observed in rabbits and all responded to the 33.1 kDa band. A structural model of LaAcE was used to guide mutational analysis of hydrophobic substrate-binding region, which was composed of Leu156, Phe164, and Val204. Fabrication and application of a non-contact double-tapered optical fiber tweezers. Data are presented which suggest that traumatic attachments, expressed in episodes of hyperarousal and dissociation, are imprinted into the developing limbic and autonomic nervous systems of the early maturing right brain.

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