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Apalene (Adapalene)

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Apalene is a retinoid. While experts aren't exactly sure how it treats acne, they believe it works by stopping pimples from forming under the skin and lowering the amount of redness and inflammation on the skin.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Vandep

Similar Products:
Clomid, Claritin, Norvasc, Ceclor, Nimotop, Terramycin, Celexa

Also known as: Adapalene


{name} (adapalene) is a topical medicine (a medication that is applied to the surface of the skin) similar to vitamin A. It helps the skin to renew itself.

{name} is used to treat severe acne in people who are at least 12 years old. It works by decreasing acne formation.


Follow the directions for using this medicine provided by your doctor. Use Apalene exactly as directed. Apalene is best applied after washing and drying your skin. Apply a thin layer of gel to the affected areas once daily at bedtime. Avoid the eyes, lips and nose. Do not allow this preparation to come into contact with the mucous membranes (e.g. mouth, vagina, inside of nose etc.). Try not to touch the treated areas overnight. Do not use any harsh soaps or exfoliants while you are being treated with Apalene. Apalene should not be used on broken, sunburnt or infected skin. You may notice a slight change of colour of the skin you are applying this preparation to. This is only temporary and should return to normal soon after finishing treatment with Apalene. Continue using Apalene until no new acne spots appear. You may need to use it for several months. You should notice some clinical improvement after 4-8 weeks and more improvement after further use. There may be a worsening of acne during the first few weeks of therapy because Apalene promotes the growth of pimples that have begun to form but are not yet visible. Therefore, treatment should not be stopped if acne appears to be worsening. Use a sunscreen cream and wear protective clothing if exposure to strong or prolonged sunlight cannot be avoided. Weather extremes such as wind or cold may also be irritating.


Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include skin redness, scaling, or irritation.


Store at a room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture, light and heat. Throw away the after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Apalene are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

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Further declines in infant mortality rates in Massachusetts will depend on preventive measures to reduce the incidence of congenital malformations. The same pretreatment given simultaneously with 2-acetylaminofluorene (2-AAF) inhibits the hepatocarcinogenicity in the rat but not in the hamster. Young people from 16 to 24 years of age protected themselves more in sexual intercourse, particularly with eventual partners. In South Africa, anti-tobacco advertising, promotion and sponsorship policies became more comprehensive over time and were more strictly enforced, whereas the partial anti-tobacco advertising, promotion and sponsorship policies adopted in Botswana were weakly enforced. To determine the prevalence, attitude and knowledge of self-medication amongst university students of Karachi, Pakistan. The risk of developing osteoporosis increases with age and is relatively higher in women and in the Caucasian population.

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Effectiveness of rosiglitazone in reducing flexion contracture in a rabbit model of arthrofibrosis with surgical capsular release: A biomechanical, histological, and genetic analysis. Host-parasite interactions might also have impacted the fine-scale structure of A. Our data suggest that OSM is a promising therapeutic target for LF. However, AC fields were found to restore and even promote pollen growth. SVG and mUcn2 dose-dependently increased CBF while decreasing MABP and colonic vascular resistance (CVR). Ciprofloxacin for respiratory tract infection with Pseudomonas aeruginosa. In March 2014, the patient switched to denosumab (which had become available in the center), and continued with hormone therapy. MBC treatment also produced an altered spindle pole body morphology, causing the disappearance of the outer component.

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Advanced age alone should not be a contraindication for potentially curative chemoradiotherapy-based treatment in esophageal cancer patients. To evaluate the effect of end-stage pediatric liver disease and liver transplantation on growth and final height. Finally, several distinct strategies to improve microwave energy utilization efficiencies are proposed and discussed with the aim of tackling the energy-efficiency-related issues arising from the application of microwave heating. Involvement of articular cartilage in a linear relaxation process during walking. Resident self-report data came from 16,017 individuals who resided in 355 LTCFs. Median (10th and 90th percentiles) number of cases performed as surgeon chief, surgeon junior and teaching assistant (TA) were analyzed using R(2) for all trends. Familiarity, subjectively defined, is sensitive to intentions and can play a key role in strategic control.

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Both valproate (VPA) and lorazepam (LZP) are primarily cleared from the body by glucuronidation. Ultrastructural study of mother and daughter muscle changes with mitochondrial encephalomyopathy. DPPH Radical Scavenging and Postprandial Hyperglycemia Inhibition Activities and Flavonoid Composition Analysis of Hawk Tea by UPLC-DAD and UPLC-Q/TOF MSE. Concentrations of LSD determined by the assay are compared with concentrations determined by two other methods of analysis, a radioimmunoassay and a high-performance liquid chromatographic (HPLC) assay. Ameliorative effect of methanol extract of Rumex vesicarius on CCl4-induced liver damage in Wistar albino rats. Here, we highlight the multiple molecules potentially targeted by n-3 PUFAs to trigger cancer cell apoptosis. To image and measure whole eye segments using dual-channel spectral-domain optical coherence tomography (SD-OCT) and to compare the results with those from the IOLMaster (Carl Zeiss Meditec, Dublin, CA). Classification of Imbalanced Data by Oversampling in Kernel Space of Support Vector Machines.

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In the modern era of surgery, minimally invasive surgery is increasingly applied for excision of gastrointestinal stromal tumors. We investigated the association between code status discussion on admission and incidence of invasive procedures, cardiopulmonary resuscitation (CPR), and opioid use among inpatients with advanced stages of cancer and noncancer diseases. Combined anaerobic digestion and biological nitrogen removal for piggery wastewater treatment: a modelling approach. The SpO2/FiO2 ratio can be used to calculate PaO2/FiO2 and determine the oxygenation state of patients with acute respiratory failure. Erratum: A novel humanized mouse lacking murine p450 oxidoreductase for studying human drug metabolism. This paper introduces a high temperature plasma light source that is both ultra-broadband and has much more radiant power in the infrared spectral range than conventional, table-top thermal light sources such as the globar. Hidden allosteric sites, as a novel type of allosteric site, are invisible in ligand-unbound (apo) crystal structures, but can emerge in ligand-bound (holo) crystal structures when a specific ligand binds to, and stabilizes, a unique conformation favored by the ligand. Flavonoid profiles of three Bupleurum species and in vitro hepatoprotective of activity Bupleurum flavum Forsk. tenormin tablet cortisol, tetrahydrocortisol, and tetrahydrocortisone did not occur. Predominately antigen-expressing DCs migrated after mRNA transfection.

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Apparent absence of recovery in endogenous colony-forming cells after irradiation under hypoxic conditions. Malic enzyme mRNA from MOD-1 null mice contains an internal in-frame duplication that extends the coding sequence by 522 nucleotides. Chemotherapy: principles and application in head and neck tumors. These foot mobility factors typical pediatric dose of zithromax should be considered in the clinical management of knee-related disorders that are associated with a high FPPA. Salience network dynamics underlying successful resistance of temptation.

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Early evaluation of thyroid function in anticholinesterase pesticide poisoning subjects is suggested, especially in subjects without atropine treatment, aged 40-64 years, female sex, and past history of goiter. The treatment of patellar dislocation has changed considerably since we gained a better understanding of the unique anatomy of the patellofemoral joint. Interaction between different sports branches such as taekwondo, box, athletes and serum brain derived neurotrophic factor levels. The application of liver scan to the diagnosis of esophageal varices. Treatment with fructose for 4 weeks increased the BP, serum fasting insulin, glucose, homeostatic model assessment-insulin resistance, and triglyceride levels and reduced the serum direct high-density lipoprotein level in the fructose group.

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A ligand-inducible epidermal growth factor receptor/anaplastic lymphoma kinase chimera promotes mitogenesis and transforming properties in 3T3 cells. Recently it was shown that P450-4 and P450-1 encode multifunctional enzymes catalyzing the three oxidation steps from ent-kaurene to ent-kaurenoic acid and the four oxidation steps from ent-kaurenoic acid to GA14, respectively. The experience of ECT is individualized for each patient, and CBT can be a successful treatment in those who have anxiety related to ECT. The protocol focused on admission assessment, education, and provision of standing orders for medication treatment for nicotine withdrawal and/or tobacco cessation therapy during the inpatient encounter and referral for outpatient counseling at discharge. The pulmonary veins and venules in lungs of newborn infants with hyaline membrane disease can be completely filled with a barium sulfate solution.

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Grandparenting experiences among adults with a history of depression: a mixed-methods study. Following freezing, microtome sectioning was performed to reveal anatomic features down to 100 microm. Longevity of an experimental infection with Dirofilaria immitis in a dog. Critical appraisal highlighted uncertainties over risk of bias from missing details in the trial publications that would be overcome with the provision of accompanying trial protocols, as well as the need for a head-to-head trial against an IL-17 inhibitor. A novel one-step synthesis of anthraquinones and chloro anthraquinones from simple ketone precursors and phenylselenyl chloride is also described. The results therefore support the hypothesis of a relationship between UPE emissions and, in the oscillations, the local gravimetric tide. This is the first report of a group I intron-derived ribozyme being capable of catalyzing the insertion of a modified oligonucleotide into RNA. We examined whether membership in latent classes (LCs) differentiated by PA and sleep profiles (real-life clustering of behaviors in population subgroups) zithromax 500mg tab associate with metabolic risk factors and CVD risk. Pericytes were described nearly 140 years ago by the French scientist Charles-Marie Benjamin Rouget and were referred to as the Rouget cell. In parallel, focused transcription analyses were performed in cry1a- and in CRY2-OX tomato genotypes.

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Revascularization reduces the risk of a major amputation or inpatient death for patients with CLI when compared to conservative therapy. The microbial community structure in 2-chlorophenol-acclimated anaerobic granular sludge and inoculating sludge were analyzed by 16S rDNA-based approach. The purpose of this study is to determine whether second-year medical students can be taught to perform a nutritional Subjective Global Assessment (SGA). The more the medication used by the patient, the greater the likelihood there is of the patient being subjected to potentially inappropriate drug therapy (PIDT). The proficiency and efficiency of the algorithm were evaluated using scenarios, while the user interface was assessed using a mobile heuristics evaluation tool, with its usability determined using the Post-Study System Usability Questionnaire. The conformational change that connects the two states primarily involves the tilting of a 4-helix bundle composed of transmembrane helices 1, 2, 6, and 7. A screening procedure based on the formation of lactose-fermenting papillae on lactose-non-fermenting bacterial colonies has been described. Childhood cancer in the offspring born in 1921-1984 to US radiologic technologists.

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Efficient tumor targeting by single-domain antibody fragments of camels. Our results present morphological evidence that GDNF-RET interaction plays important roles in physiological processes of nigrostriatal neuronal circuits of mammals. HepG2 cells were cultured and cozaar 50 mg tabs pGL3-hTERT-TK and AF-liposome were constructed. Organ-specific fungal infections as a complication of treatment of children with cancer. In this study, to explain the pathogenesis of cauda equina syndrome, monoaxial tensile tests were performed to determine the strength characteristics of spinal nerve roots and rami radiculares, and analysis was conducted to evaluate the stress-strain relationship and strength characteristics. Reliabilities and consistencies were judged sufficiently adequate for use of these types of judgments in a multidimensional scaling approach t o individual differences in social perception. Because HIF is activated only to suboptimal levels in various pathogenic states, therapeutic activation holds promise as a novel and effective approach to the future care of end-stage renal disease.

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