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Apgel (Adapalene)

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Apgel treats acne deep in the pores at the source, prevents new acne from forming and, as a result of reduced acne, restores your skin’s natural texture and tone. Apgel has been prescribed to more than 40 million people over the last 20 years.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

Similar Products:
Zithromax, Trandate, Mircette, Panadol, Sumycin, Ultram, Glyburide, Prograf

Also known as: Adapalene


{name} (adapalene) is a topical medicine (a medication that is applied to the surface of the skin) similar to vitamin A. It helps the skin to renew itself.

{name} is used to treat severe acne in people who are at least 12 years old. It works by decreasing acne formation.


It is very important that you use this medicine only as directed. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause irritation of the skin.

Do not apply this medicine to windburned or sunburned skin or on open wounds.

Do not use this medicine in or around the eyes, lips, or inside of the nose. Spread the medicine away from these areas when applying. If the medicine accidently gets on these areas, wash with water at once.

Apply the medicine to clean, dry areas of the skin affected by acne. Rub in gently and well. Wash your hands afterwards to remove any medicine that may remain on them.

To help clear up your acne completely, it is very important that you keep using this medicine for the full time of treatment , even if your symptoms begin to clear up after a short time. If you stop using this medicine too soon, your acne may return or get worse.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For topical dosage form (gel): For acne: Adults and teenagers—Apply a small amount as a thin film once a day, at least one hour before bedtime. Apply the medicine to dry, clean areas affected by acne. Rub in gently and well. Children—Use and dose must be determined by your doctor.


If you overdose Apgel and you don't feel good you should visit your doctor or health care provider immediately.


Store at a room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture, light and heat. Throw away the after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Apgel are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

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After binding either alcohol, the low-frequency resonance Raman spectra of human ferrihemoglobin are almost identical to the unperturbed spectrum except for shifts in the 309 cm-1 band to higher frequency by as much as 8 cm-1. Results highlight that most of sexually dimorphic measurements useful for pinpointing the greater palatal foramen do not depend upon the cranium size. Two other populations of each of the tryptophan-modified isoforms were identified. Commonly used cell-free DNA (cfDNA) originates from dying cells. Sudden blindness as an initial manifestation of localized fusariosis in ethmoid sinus and optic nerve.

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Its occurrence with ossification and diffuse argyrophil-cell hyperplasia. Trueness and precision of the real-time RT-PCR method for quantifying the chronic bee paralysis virus genome in bee homogenates evaluated by a comparative inter-laboratory study. Epilepsy results from alternations in fundamental mechanisms of brain and membrane function. Respondents reported various psychological problems such as difficulty in engaging in sexual intercourse, anxiety, worry and stress, depression, low self-esteem, feeling weak, fear of being abandoned, and fear of transmitting disease to the children. Knosp tumor grades based on magnetic resonance imaging coronal scanning were used to assess the invasiveness of each sample. A further aim was to assess the relationship between handgrip strength and pulmonary function in patients with SSc. Peptidergic neurohormonal systems in the basal hypothalamus of the ferret and the mink: immunocytochemical study of variations during the annual reproductive cycle. Can a modified esophageal stent be useful in the treatment of nonresponsive benign colonic anastomotic stenosis?. Severe chest pain in a pediatric ulcerative colitis patient after 5-aminosalicylic acid therapy.

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Among several echocardiographic variables most consistent alteration was shortening of E-deceleration time of mitral as well as RV inflow, more abnormal in pts without thrombolysis. The purpose of our work was to verify such a notion and ascertain the relation between spontaneous and tread-mill induced claudication. To investigate how the use of telephone consultations impacts on the management of requests for same-day appointments, on resource use, indicators of clinical care, and patient perceptions of consultations. Deroofing: An Effective Method for Treating Chronic Diffuse Hidradenitis Suppurativa. paradoxus is a very rare member of the oak bark microbial community. When treated with tigecycline and miR-199b-5p antagomir simultaneously in glioma cells, we found that miR-199b-5p antagomir could partly block the effects induced by tigecycline. BCOR-CCNB3 sarcomas share clinical and pathologic similarities with Ewing sarcoma, but show a stronger male predilection and less aggressiveness, as well as distinct gene expression profiling and pangenomic SNP array analyses.

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We recently demonstrated that extracellular nucleotides, and particularly UTP, induced migration of cultured arterial smooth muscle cells (ASMCs). Chlorhexidine gluconate ingestion resulting in fatal respiratory distress syndrome. A 61 year-old man with type 2 diabetes mellitus presented with an extremely rapid and aggressive mononeuritis multiplex. This study examined the cucumber-Bacillus amyloliquefaciens SQR9 system and found that SQR9, a bacterium previously shown to enhance the growth of cucumber, increased root secretion of tryptophan by three- to fourfold. Effects of musculoskeletal system problems on quality of life and depression in students preparing for university entrance exam. Quality of life in patients with malignant spinal cord compression: a review of evidence-based literature. We report herein an unusual case of thyrotoxicosis caused by acute suppurative thyroiditis (AST) infected through a piriform sinus fistula (PSF is claritin a nsaid drug ).

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In a phase II clinical trial in nine obese, insulin-resistant humans, we observed that treatment with KDT501, a novel isohumulone drug, increased total and high-molecular weight (HMW) adiponectin in plasma. Breeding for cuticle-associated traits in crop species: traits, targets, and strategies. The Orguiel was similar to the Gunflint chert and Type II meteorites were similar to the Soudan rock. A decline in hepatitis B virus surface antigen (hbsag) predicts clearance, but does not correlate with quantitative hbeag or HBV DNA levels. The operations were performed in one centre by the same surgeon with the same trephine (Guided Trephine System, GTS) and special instrumentation for DALK (Geuder, Heidelberg). It turned out that the two IMC delivery systems established by CMSN and Amino-CMSN significantly improved drug intestinal permeability due to the improved drug dissolution caused by conversion of drug crystalline state to amorphous phase. This observation implies that te apo state of GluR6 undergoes a cleft closure of 29-30 degrees upon binding full agonists, one of the largest observed in the glutamate receptor family.

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The effect of proton pump inhibitors (PPI) in Asian functional dyspepsia (FD) patients has not been well established as in Westerncountries. Transesophageal echocardiographic evidence of atrial fibrillation with systolic flow in the right atrial appendage and systolic reversal pulmonary flow in a patient with DDD permanent pacing. OSTEOID OSTEOMA OF THE CORACOID PROCESS: CASE REPORT WITH LITERATURE REVIEW. Only the all-in-one adhesive was influenced by the deproteinization. PGE2 and PGI2 inhibit the vasoconstrictor responses elicited by sympathetic nerve stimulation and by injected norepinephrine in the rabbit and dog kidney. Discussion about food taboos during antenatal care visits and during community education can help reduce the traditional belief about certain food in pregnancy and early childhood. Management of the pancreatic remnant after distal pancreatectomy is still debated, the most serious complication is development of a pancreatic fistula. In this paper, we propose the mixed spectrum analysis of the voxel time-series to separate the discrete component corresponding to input stimuli and the continuous component carrying temporal autocorrelation.

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Cryptochromes (CRY) are flavoproteins that direct a diverse array of developmental processes in response to blue light in plants. Endothelial immune activation and functional state in patients with hypertensive disease. Characterization of disulfide-linked crystallins associated with human cataractous lens membranes. Disruption of gap junction and transfer of cyclic nucleotides to the oocyte lead to meiotic exit from diplotene arrest (EDA) in mammals. Although nonresistant and resistant staphylococci still lead the list, gram-negative, mixed infections and anaerobic organisms have become more evident. The effect of recording site on extracted features of motor unit action potential. Successful induction of can depakote overdose cause death granulomatosis with polyangiitis with tacrolimus. Paracrine and autocrine regulation of gene expression by Wnt-inhibitor Dickkopf in wild-type and mutant hepatocytes.

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