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Assoral (Roxithromycin)

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Assoral is indicated for the treatment of the following types of mild to moderately severe infections in adults caused by or likely to be caused by susceptible microorganisms. Upper respiratory tract infections: acute pharyngitis, tonsillitis, sinusitis.

Other names for this medication:
Acevor, Assoral, Azuril, Bazuctril, Biaxsig, Cadithro, Claramid, Delos, Dorolid, Elrox, Erybros, Ladlid, Macrolid, Macrosil, Makrodex, Monobac, Nirox, Overal, Pedilid, Pedrox, Redotrin, Remora, Renicin, Ritosin, Rokilide, Roksolit, Rolexit, Rolicyn, Romac, Romyk, Roxacine, Roxithromycin, Roxithromycinum, Roxitromicina, Rulid

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Also known as: Roxithromycin


Assoral is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. Assoral is derived from erythromycin, containing the same 14-membered lactone ring. However, an N-oxime side chain is attached to the lactone ring. It is also currently undergoing clinical trials for the treatment of male-pattern hair loss.

Assoral is available under several brandnames. Assoral is not available in the United States. Assoral is available in Australia, Israel and New Zealand. Assoral has also been tested to possess antimalarial activity.

Assoral prevents bacteria from growing, by interfering with their protein synthesis. Assoral binds to the subunit 50S of the bacterial ribosome, and thus inhibits the synthesis of peptides. Assoral has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila.


Take Generic Assoral by mouth with food. If you have trouble swallowing the tablet whole, it may be crushed or chewed with a little water. Swallow Generic Assoral tablets whole with a glass of water. Generic Assoral should be taken at least 15 minutes before food or on an empty stomach (i.e. more than 3 hours after a meal). Generic Assoral works best if you take it on an empty stomach. For treating bacterial infections, Generic Assoral is usually taken for 5 to 10 days. If you want to achieve most effective results do not stop taking Generic Assoral suddenly.


Immediately telephone your doctor or pharmacist. Do this even if there are no signs of discomfort or poisoning.


Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture, light and heat. Do not store in the bathroom. Keep in a tight, light-resistant container. Keep out of the reach of children.

Side effects

The most common side effects associated with Assoral are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


The safety of roxithromycin has not been demonstrated in patients with impaired hepatic or renal function. Caution should be exercised if roxithromycin is administered to patients with impaired hepatic or renal function. If administered to patients with severe impaired hepatic function (eg. hepatic cirrhosis with jaundice and/or ascites), consideration should be given to reducing the daily dosage to half the usual dosage.

Prolonged or repeated use of antibiotics including roxithromycin may result in superinfection by resistant organisms. In the event of superinfection, roxithromycin should be discontinued and appropriate therapy instituted.

When indicated, incision, drainage or other appropriate surgical procedures should be performed in conjunction with antibiotic therapy.

Antibiotic associated pseudomembranous colitis has been reported with many antibiotics. A toxin produced by Clostridium difficile appears to be the primary cause. The severity of the colitis may range from mild to life threatening. It is important to consider this diagnosis in patients who develop diarrhoea or colitis in association with antibiotic use (this may occur up to several weeks after cessation of antibiotic therapy). Mild cases usually respond to drug discontinuation alone. However, in moderate to severe cases, appropriate therapy with a suitable oral antibacterial agent effective against Clostridium difficile should be considered. Fluids, electrolytes and protein replacement therapy should be provided when indicated.

Roxithromycin, like erythromycin, has been shown in vitro to elicit a concentration - dependent lengthening in cardiac action potential duration. Such an effect is manifested only at supra – therapeutic concentrations. Accordingly, the recommended doses should not be exceeded. In certain conditions macrolides, including roxithromycin, have the potential to prolong the QT interval. Therefore roxithromycin should be used with caution in patients with congenital prolongation of the QT interval, with ongoing proarrhythmic conditions (ie uncorrected hypokalemia or hypomagnesaemia, clinically significant bradycardia), and in patients receiving Class IA and III antiarrhythmic agents.

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T cell responses to human recombinant acetylcholine receptor-alpha subunit in myasthenia gravis and controls. We also suggest considering performing chest X-ray earlier in the diagnostic work-up. To examine behavioral observations of affiliation (ie, warmth versus hostility) and control (ie, dominance versus submissiveness) and prior divorce as predictors of coronary artery calcification (CAC) in older couples. The Arg-Gly-Asp (RGD) recognition site of platelet glycoprotein IIb-IIIa on nonactivated platelets is accessible to high-affinity macromolecules. Measuring the looseness of the knee joint by using the Kt 1000 arthrometer. Finally, calponin was effective in inhibiting ATPase activity of cross-linked acto-subfragment 1. In addition to this function, many chemokines have also been found to mediate the direct killing of a range of pathogenic microorganisms through an as-yet-undefined mechanism.

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This suggests an inverted U-shaped relationship may exist between both neonatal corticosterone levels and adult GR expression in the interpositus nucleus, and adult GR expression in the interpositus and eyeblink conditioning. More patients on hydrochlorothiazide attained a diastolic blood pressure of less than 90 mmHg while less patients required doubling of dosage compared to timolol and enalapril. These changes in response time variability were however not dependent on time on task, which is likely due to the modest level of sleep drive in our study. Secondarily, it assesses whether response to treatment differs by etiology or developmental status. The Monfort operation for abdominal wall reconstruction in the prune belly syndrome. Using a clinical 3T scanner (echo/repetition times, 30/5000ms), single-voxel MRS data were obtained from the basal ganglia (BG) and centrum semiovale (CS) in 48 healthy neonates (postconceptional age (PCA), 30-43weeks), nine infants (age, 1-12months old), and 20 children (age, 4-15years). In particular, the spectral properties and the scaling behaviour of probability density functions (PDFs) of light intensity fluctuations are considered at different voltages. Thermodynamics of chitinase partitioning in soy lecithin liposomes and their storage stability. PC12 cells express NGF-receptors (trkA) and respond to NGF by forming neurites, branches and synaptic vesicles.

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Physical and oxidation stability of self-emulsifying krill oil-in-water emulsions. Aseptic technique as a safety precaution in the preparation of antineoplastic agents. To determine the long-term results of femtosecond-assisted MyoRing implantation for the treatment of keratoconus. The c-kit proto-oncogene encodes a tyrosine kinase receptor (KIT) which is expressed on many types of human cells. Less-educated patients anticipated needing more time with the surgeon.

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We report computed tomography and endoscopic findings after hyaluronic acid/dextranomer injection in the ano-rectal area. We aimed to estimate the risk of ischemic stroke after intracranial hemorrhage in patients with atrial fibrillation. These results suggest that the presence of fQRS on ECG was associated with an increased in-hospital cardiovascular mortality, and one-year all-cause mortality in patients with STEMI who are under primary PCI. Elevated levels of angiopoietin-2 as a biomarker for respiratory failure after cardiac surgery. In this work, the radio wave characterization for ISM 2.4 GHz and 5 GHz Wireless Sensor Networks (WSNs) deployed taking advantage of the existence of traffic light infrastructure has been assessed. As pertinent examples, we focus on the molecular SbCl(5) and HNO(3) intercalates, and the solid compound AlCl(3). Results show that consumer preferences for cost and convenience create a strong market for free-standing emergency facilities.

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The exon junction complex component Y14 modulates the activity of the methylosome in biogenesis of spliceosomal small nuclear ribonucleoproteins. These advancements lead to introducing the addition of a fourth-dimension, time, to the three-dimensional geometry in EBRT. The exposed root surfaces were curetted in order to remove the periodontal ligament tissue, and a notch was made in the root surface at the base of the defects. Sirtuins are considered the main erasers of these modification marks, and thus contribute to acylation-dependent regulation of enzyme activity, and potentially of protein quality control. Use of urine as a diagnostic medium may allow the noninvasive detection of incipient nephropathy in these patients. These data confirm an increase in maternal weight gain before and during pregnancy. Analyses yielded 10 scales of the SAQ: Withdrawal, Social Improvement/Non-smoker Identity, Adverse Outcomes, Treatment Effectiveness, Common Reasons, Barriers to Treatment, Social Support, Optimistic Outcomes, Coffee Use and Weight Gain. To explore the correlation between microRNA (miR)-200c and the severity of interstitial lung disease (ILD) associated with connective tissue diseases (CTDs). Transgenic Populus expressing a microRNA-resistant form of PRE presents unstable phenotypic abnormalities affecting both primary and secondary growth.

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Epoxyeicosatrienoic acids (EETs) are formed from arachidonic acid by the action of P450 epoxygenases (CYP2C and CYP2J). The curvature of the channel membrane and the depth of the radially spreading solution can be explained in terms of the solution densities and the interfacial tension across the semipermeable membrane. Intracellular restoration of miR-542-3p further promoted TNBC cell apoptosis via activating p53 and inhibiting survivin expression. This study provides descriptive epidemiological data, such as the percentage of cases diagnosed, crude incidence rate (CIR), and age-standardized incidence rate (ASIR) of ovarian cancer in Saudi Arabia from 2001-2008. Functional Short-Bite Ligands: Synthesis, Coordination Chemistry, and Applications of N-Functionalized Bis(diaryl/dialkylphosphino)amine-type Ligands. In 27 of 28 cases the biopsy diagnosis was identical to the final diagnosis. Optimized angiographic CT using intravenous contrast injection: a noninvasive imaging option for the follow-up of coiled aneurysms?. The increase of effective blood viscosity caused by elevation of packed cell volume was greater than the increase in O2 binding capacity resulting from the elevated haemoglobin concentration, suggesting that the haemoconcentration observed in the exercising greyhound does not enhance O2 delivery to skeletal muscle. Furthermore, a measurement of self-efficacy could be used to predict nursing clinical performance. The use of 2-D PAGE in phenotypic assessment provides a more complete analysis than the standard range of single-parameter tests for osteoblasts.


Characterizing these mutations aided in uncovering the role of ribose-5-P (a transketolase substrate) as an inhibitor of glycerol assimilation and de novo glycerol-3-P synthesis. We have characterized this system further by analyzing polypeptide interactions under both reducing and oxidizing translation conditions. The defects observed were those affecting the neural tube (NTD) (exencephaly, encephaloceles, and microphthalmia), kyphosis/scoliosis, branchial arch defects, and pericardial edema. Closing information gaps with shared electronic patient summaries: how much will it matter?. However, manual inspection and matching of PSL is a subjective, tedious, and error-prone task. The former laboratories produced fewer false and outlying results, and were more accurate and precise in their determinations.

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Effects of gamma interferon and indomethacin in preventing Brucella abortus infections in mice. Safety and feasibility of radiofrequency ablation for treatment of Bosniak IV renal cysts. Intrauterine growth retardation (IUGR) and postnatal nutrition are risk factors for adult metabolic syndrome. We reviewed PCT and firstly acquired CBCT datasets of each ten patients with prostate cancer. Laparoscopic right hemicolectomy with D3 lymph node dissection for a patient with situs inversus totalis: report of a case. Although it remains to be determined whether local therapy is best pursued through LN dissection or through a combination of resection with radiation, prevention of regional metastases is an important goal in the treatment of cancer patients to achieve a better survival. Whether the adult mammalian ovary contains oogonial stem cells (OSCs) is controversial. The membrane-associated guanylate kinases (MAGUKs), which are typically associated with cell junctions, have a major role in the organization of protein-protein complexes at plasma membranes and are therefore potentially important caspase targets during apoptosis. Use of lanreotide in combination with cabergoline or pegvisomant in patients with acromegaly in the clinical practice: The ACROCOMB study. On the face of it, it makes sense, If you want to involve your employees more in decision making and shift the organization toward a more participative culture, starting suggestion groups called quality circles seems to be a risk-free way to begin.

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Our proposed guidance could help RCT authors to better report, and readers to better identify participants with missing data. Network interactions between caudate putamen and hippocampus contralateral to the right tetanized corpus callosum in rats. A meticulous vascular survey makes it possible to obtain valuable clues in cases such as caudate haemorrhage due to pseudoaneurysm of the accessory middle cerebral artery, leading to prevention of rebleeding. pharmaceutical forms (presentations) influence treatment compliance and therefore the effectiveness. Specific carbethoxylation suggested they have different roles: one is required for specific receptor binding, one for oligomerisation and two for unspecific lipid binding. These conditions often present with recurrent acute attacks of metabolic acidosis, hypoglycemia, liver failure, and hyperammonemia that may be prevented with initiation of early treatment. This finding suggests that human arylsulfatase A undergoes similar proteolytic processing regardless of the tissue involved. The Clermont score and the apparent diffusion coefficient value can stage ileal CD, avoiding the need to use contrast agents. Time series analysis of out pateints at Urban Health Centre, Suraj Kund, Meerut, was done using the out patient attendance of the last 5 years.

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Seasonal variation in soluble sugars concentration was opposite to cambial activity, with minima seen during periods of maximal secondary growth, and did not differ between the sexes or sites. The Oxford classification of IgA nephropathy: a retrospective analysis. Follicular fluids, corresponding to these oocytes, contained p30- and gp70-related antigens, reverse transcriptase, and an increased titer of interferon. We conceptualize the interaction of pain and smoking as a prototypical example of the biopsychosocial model. Pulmonary lesions were quantitatively reduced in alpha 1Pi-administered BLM-treated (BLM-alpha 1Pi) animals compared with animals treated by BLM alone (BLM-control) at both 7 days (acute stage) and 30 days (fibrotic stage) after BLM treatment.

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Adult patients were not seen to have corrections of bones and neurologic disorders after the treatment that confirmed necessity of an early initiation of the treatment, before formation of irreversible changes in these organs and systems. The FERMO concept emerges as a powerful and innovative implement to investigate the role of molecular orbitals applied to the description of breakage and formation of chemical bonds. Moreover, dexmedetomidine has negligible adverse effects, whereas tramadol is associated with significant nausea and vomiting. Not all chorioangiomas are associated with elevated maternal serum alpha-fetoprotein. However, data on the already-implemented Flexible spectral Imaging (or Fujinon Intelligent) Color Enhancement (FICE) software application in VCE are limited. Multidrug antituberculosis regimen is associated with diverse clinical patterns of cutaneous adverse drug reactions (CADR), ranging from mild and moderate such as pruritus, maculopapular exanthems, lichenoid eruptions, fixed drug eruptions and urticaria to severe and even life threatening ones like acute generalized exanthematous pustulosis (AGEP), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN).

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Analysis of the data obtained from the enumeration of live cells showed no statistically significant difference between the unmodified graft group and the control group. The full potential of such therapy can only be realised if the fundamental mechanisms leading to lethal cell damage under ion irradiation are well understood. However, immunisation by the old schedule led to significantly atenolol 25 mg para que serve higher antibody concentrations against both diphtheria and tetanus than did immunisation by the new schedule (p less than 0.01). In this respect, hydroxyapatite scaffolds with highly porous architecture are very promising materials, due to the excellent biocompatibility and intrinsic osteogenic and osteoconductive properties that enable deep bone penetration in the scaffold and excellent osteointegration. The present study showed that patients with PNESs diagnosed with PTSD exhibited memory functions that were significantly different from those in patients with PNESs who do not carry a diagnosis of PTSD (regardless of history of trauma). Findings - The different theoretical approaches can be associated with different ways of understanding priority setting.

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In this study, we aimed to evaluate the effectiveness and safety of the Exoseal vascular closure device (Cordis Corporation, Bridgewater, New Jersey, USA) for puncture site closure after antegrade endovascular procedures in peripheral arterial occlusive disease (PAOD) patients. The available synthetic drugs to treat liver disorders in this condition also cause further damage to the liver on long-term use. No reduction of splenic infection was shown with anti-25-27- or -36-38-kDa MAbs, whereas anti-lipopolysaccharide (LPS) MAb which was produced in CBA mice was effective. In case of high frequency hearing loss peak I is often hard to determine, and peak V latency may be shifted not only by neural delay, but also by missing basal hair cells. Dosimetric comparison of stopping power calibration with dual-energy CT and single-energy CT in proton therapy treatment planning.

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Notably, abiotic stresses affected differently the splicing of chloroplast tRNAs and mRNAs in coffee plants and rice seedlings. Biogenic synthesized silver-based nanoparticles are not completely characterized, particularly the nature of capped proteins covering the nanomaterials. In addition, context specificity of the adaptation was addressed by measuring inter-limb transfer and transfer to visual and proprioceptive perceptual tasks. Ultrasound-guided maximum daily dose of glyburide axillary plexus block in a child with dystrophic epidermolysis bullosa. Participants were children and caregivers of six local government areas in Melbourne participating in the community-based Early Language in Victoria Study (ELVS). Prevalence of specific antibodies to Chlamydia pneumoniae (TWAR) in Swedish orienteers. Two novel antimicrobial peptides, arasin-likeSp and GRPSp, from the mud crab Scylla paramamosain, exhibit the activity against some crustacean pathogenic bacteria. Here, we report crystal structures of the catalytic domain of Chk2 in complex with a novel series of potent and selective small molecule inhibitors. Constrained Source Apportionment of Coarse Particulate Matter and Selected Trace Elements in Three Cities from the Multi-Ethnic Study of Atherosclerosis. Economic burden of amyotrophic lateral sclerosis: a Canadian study of out-of-pocket expenses.

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The case history was supplemented with prophylactic recommendations. A clinical measure of DNA methylation predicts outcome in de novo acute myeloid leukemia. Nine patients have subsequently undergone a second-stage asacol 500 mg procedure. Experimental results demonstrate that the proposed algorithm is easy to implement and computational efficient. We identified patients with solid tumors who were treated with checkpoint inibitors and had received commercially available next generation sequencing (NGS). Is cardiorespiratory fitness a determinant of cardiomyopathy in the setting of type 2 diabetes?. Japanese clinical statistical data of patients with primary hypotension. These results suggest that ER stress is critical for regulation of DC apoptotic process in response to VacA stimulation.

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Movement disorders and psychological tests of frontal lobe function in schizophrenic patients. Changes in tight junction protein expression in intrinsic aging and photoaging in human skin in vivo. In a one-back task, BOLD activity in the left mid-fusiform was inversely related to word-likeness, such that the least activity was observed in response to real characters, and the greatest to artificial stimuli that violate the orthotactic constraints of the writing system. Together, these data suggest that these novel ESP-NGCs are biocompatible, and may thus provide a reliable scaffold for peripheral nerve repair in clinical application. Immunohistochemical study and interphase fluorescence in situ hybridization (FISH) analysis were carried out. Our results demonstrated that VF was associated with trabecular radius alteration and emphasized the potential detrimental effect of disease damage on this condition. Glycerolipids, sphingolipids, and sterol lipids constitute the major lipid classes in plants. Automatic patient-customised 3D reconstruction of human costal cartilage from lung MDCT dataset. Zoledronic acid strongly stimulated autophagy but not apoptotic signals in all tested cells.

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Third wave behavior therapies such as Acceptance and Commitment Therapy (ACT) and Dialectical Behavior Therapy (DBT) comprise novel approaches and methods that have great potential to address complex substance abuse cases. Further, in vivo, intradermal injection of the enzyme solution prepared from immature okra pods led to increased capillary permeability in guinea pigs, in contrast to heated preparations. The mass was a well-differentiated liposarcoma, which was completely resected with clear margins. Surgical complications, increasing age, and impaired esophageal motility predict the development of epithelial metaplasia after repair of EA. Ondansetron 8 mg three times daily was also significantly better than placebo in the second study. To assess the time-dependent treatment effects of extracorporeal shock wave therapy (ESWT) in a standard rodent ischemic epigastric flap model. Given this scenario, it is extremely important to track the current situation of this field of knowledge in Brazil, specifically in the area of research and training. ST88-14 and NF90-8 cells underwent apoptosis, yet dying STS-26T cells did not.

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Therefore, apoptosis is not a programme of cell death but purely a termination step of a cell death programme, responsible for proper disposal of the already-committed, dying cells. How nasal function influences the eyes, ears, sinuses, and lungs. Subcellular application of pectin methyl esterase (PME), an enzyme that modifies the growth behavior by rigidifying the pollen tube cell wall, caused the tube to turn away from the agent - providing important evidence for can you overdose on metoclopramide hcl a previously proposed conceptual model of the growth mechanism. HRQoL of adolescent patients with idiopathic scoliosis can be affected by several factors that medical staff needs to consider in order to produce the best and most effective treatment outcomes. Underspecification theory says that the phonemes that have unmarked feature values are even more abstract in that the feature is omitted from the representation altogether. We relate variations in searching protocols to variation in nuptial gift size among 32 Poecilimon taxa. The molecular weights and the amino acid sequences showed similarity to those of all other known dihydropteroate synthase polypeptides. Vitreoretinal fellow surgical outcome of small gauge pars plana vitrectomy for acute rhegmatogenous retinal detachment.

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ADAM10 new selective inhibitors reduce NKG2D ligand release sensitizing Hodgkin lymphoma cells to NKG2D-mediated killing. In this work, we propose a general framework of sample weighting to improve the stability of feature selection methods under sample variations. This case illustrates the use of a microplate in the open reduction and fixation of an intracapsular mandibular condylar fracture in a patient who was unable to tolerate a closed reduction because of the nature of her chronic illness. We hypothesized that the positive recruitment effects of SLRM could also be achieved in ALI/ARDS patients. Findings indicative of significant neuropathy or myopathy are variable and in many studies subject to considerable methodological bias. The cytotoxicity of these CTL could not be inhibited with affinity-purified 2C3 Ig used as such or after pulsing with splenic tenormin dosage range antigen-presenting cells (APC). To determine the effectiveness of nutritional educational program, pre and post-tests were performed. Proton Magnetic Resonance Spectroscopy in adult cancer patients with delirium. Experiments on isolated strips of the non-pregnant rabbit and rat uterus showed the ability of dopamine, noradrenaline, serotonin, acetylcholine, prostaglandin F2 alpha, oxytocin to increase the uterine strips contractile activity. The sample consisted of postpartum psychiatric inpatients and the generalisability of results to other postpartum samples is not known.

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This study employs finite element analysis to compare the dynamic characteristics between the geometric models of an assumed simple brain tissue and a brain tissue with complex cerebral sulci. Developing a mHealth intervention to promote uptake of HIV testing among African communities in the conditions: a qualitative study. Zymodeme 5 involves only 1 isolate, which was highly pathogenic to mice. We collected blood samples from each subject to analyze serum thyroid hormones including thyroxine (T4), free T4, and thyroid-binding globulin (TBG). Arg(482) does not directly bind substrates, but electrostatically interacts with charged molecules, which initiates the conformational changes that transmit the signal from the transmembrane regions to the ABC domain.

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