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Astrim (Trimethoprim)

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Astrim (generic name: Co-trimoxazole; brand names include: Septra / Ciplin / Septrin) is a combination of two antibiotics (trimethoprim and sulfamethoxazole) used to treat a wide variety of bacterial infections.

Other names for this medication:
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Also known as: Trimethoprim


This medication is a combination of two antibiotics: sulfamethoxazole and trimethoprim. It is used to treat a wide variety of bacterial infections (such as middle ear, urine, respiratory, and intestinal infections). It is also used to prevent and treat a certain type of pneumonia (pneumocystis-type). This medication should not be used in children less than 2 months of age due to the risk of serious side effects. This medication treats only certain types of infections. It will not work for viral infections (such as flu). Unnecessary use or misuse of any antibiotic can lead to its decreased effectiveness.


Prescribing Astrim (sulfamethoxazole and trimethoprim) tablets in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.

Astrim should be given with caution to patients with impaired renal or hepatic function, to those with possible folate deficiency (e.g., the elderly, chronic alcoholics, patients receiving anticonvulsant therapy, patients with malabsorption syndrome, and patients in malnutrition states) and to those with severe allergies or bronchial asthma.

Hematological changes indicative of folic acid deficiency may occur in elderly patients or in patients with preexisting folic acid deficiency or kidney failure. These effects are reversible by folinic acid therapy.


If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe nausea/vomiting/diarrhea, severe dizziness or drowsiness, mental/mood changes.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Side effects

The most common side effects associated with Astrim are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

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Inhibitory effect of Triperygium wilfordii polyglucoside on dipeptidyl peptidase I in vivo and in vitro. Changes in concentration of glutathione, ascorbic acid and amino acids with sulfhydryl groups in experimental cataracts. Volume registration was done between the collected breath holding SPECT data and CT images. Free and protein-bound glutathione in normal and cataractous human lenses. Effect of differentiating agents on nucleolar organizer region activity in human melanoma cells.

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Early recognition and prompt management of sepsis and optimization of the process of weaning off the inotropes at the earliest opportunity are necessary to avoid SPG. Although successful in identifying new cataract-linked genes, the previous version of the database iSyTE (integrated Systems Tool for Eye gene discovery) was based on expression information on just three mouse lens stages and was functionally limited to visualization by only UCSC-Genome Browser tracks. Analysis of CFTR trafficking and polarization using green fluorescent protein and confocal microscopy. Engaging Consumers with Musculoskeletal Conditions in Health Research: A User-Centred Perspective. The zone of the early repolarization is located in the apical area, while that of the late one--in the area of the base. This paper provides a broad overview of available scientific knowledge and cites numerous studies on various aspects of soft drinks and their implications for health safety. Soluble urokinase-type plasminogen activator receptor is a novel biomarker predicting acute exacerbation in COPD. The findings suggest that EDN/EDNRB signaling may serve as a potential therapeutic target to promote repigmentation in hypopigmentation disorders. Although people with FSHD and LGMD had relatively few activity limitations, all NMD groups experienced restrictions when participating in social activities. Patients most likely to receive treatment have comorbidities, but even in those high-risk groups, treatment levels are low and recommended control levels even lower.

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Recipient plasma concentration of epithelial cell death markers (M30, M65) after lung transplantation is negatively correlated with early graft performance and long-term survival. A quantitative approach to cross-reaction problems in immunocytochemistry. Does intracoronary papaverine dilate epicardial coronary arteries?. A history of MDD prior to lifetime onset of substance dependence also reduced the likelihood of remission relative to the absence of such a history (adjusted hazard ratio, 0.49). We present BUSTED, a new approach to identifying gene-wide evidence of episodic positive selection, where the non-synonymous substitution rate is transiently greater than the synonymous rate. 2 cases of cardiac beriberi: notes on the physiopathology of cardiac manifestations in alcoholics. Cordycepin prevents postoperative formation of intra-abdominal adhesion in a rat model: An experimental study. Azulenesulfonium Salts: Accessible, Stable, and Versatile Reagents for Cross-Coupling. Nine had successful duct clearance, three had failure to cannulate, and one was converted to an open procedure due to an anatomical problem.

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Quality of life evaluation in sarcoidosis: current status and future directions. Provocation tests have been used to induce the familiar chest pain. The experimental observations are further supported by numerical evaluation using the generalized Poisson-Boltzmann equation. The effect of increasing doses of ingested glucose on insulin and gastric inhibitory glyburide 1 mg polypeptide (GIP) concentrations in man. The alpha3B chain was scarcely detected in the vessels of malignant skin cancers, though the gamma2 and beta3 chains were highly expressed in the cancer cells. The aim of this study was to investigate prevalence as well as duration and cumulative doses of intravenous bisphosphonate treatment. Dienogest constitutes a new therapeutic alternative to the GnRH analogues. Here, we tested the simultaneous effects of these factors on hemocyte concentration and phenoloxidase activity in adults of the European earwig. Evaluation of human cystic echinococcosis before and after surgery and chemotherapy by demonstration of antibodies in serum.

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