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Atenerate (Nifedipine)

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Atenerate is used to treat hypertension (high blood pressure) and angina (chest pain). Atenerate is in a class of drugs called calcium channel blockers. Atenerate relaxes (widens) your blood vessels (veins and arteries), which makes it easier for the heart to pump and reduces its workload.

Other names for this medication:
Adefin, Afeditab, Antrolin, Aprical, Atenerate, Belnif, Calchan, Cardifen, Cisday, Conetrin, Coracten, Cordalat, Cordipin, Depicor, Emaberin, Farmalat, Fenamon, Fenidina, Ficard, Ficor, Glopir, Lemar, Milfadin, Myogard, Nicardia, Nifebene, Nifecor, Nifedipin, Nifedipinum, Nifin, Nycopin, Oxcord, Sepamit, Tensomax, Tensopin, Valni, Viscard

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Also known as: Nifedipine


Nifedipine is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Nifedipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, nifedipine relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain nifedipine. It may not be specific to Atenerate OROS. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended release tablet whole. Do not break, crush, or chew it. It is best to take this tablet on an empty stomach.

If you are taking the extended-release tablets, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of chest pain or high blood pressure: For oral dosage form (capsules): Adults—At first, 10 milligrams (mg) three times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 30 or 60 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 90 mg once a day. Children—Use and dose must be determined by your doctor.


If you overdose Atenerate and you don't feel good you should visit your doctor or health care provider immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Nifedipine dosage information

Side effects

The most common side effects associated with Atenerate are:

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Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of nifedipine in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems which may require caution and an adjustment in the dose for patients receiving nifedipine.

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Validation of the simplified Chinese version of EORTC QLQ-C30 from the measurements of five types of inpatients with cancer. Although oxytocin is important in the expression of social behavior in several species, it is not known if social factors alter the ability of oxytocin to influence behavior. The advantages and shortcomings of the ion-exchange, amino and octadecylsilane systems are evaluated and one of them is selected as optimum for bulk and tablet analysis. Others affect lipid synthesis, apoptosis, alcohol metabolism, cAMP signaling, and electron transport. In vitro study of the aromatic hydroxylation of 1-methyltetrahydro-beta-carboline (methtryptoline) in rat. Recent research has revealed the novel immunomodulatory function of LXs.

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Regional climate change scenarios applied to viticultural zoning in Mendoza, Argentina. The role of hospitals in pandemic influenza planning, response and recovery. Both treatments reduced the frequency of attack markedly but there was no significant difference between the two. For advanced education programs for acupuncture manipulation, we will need to collect additional information, such as patient responses, acupoint-specific anatomical characteristics, delicate tissue-like modeling, haptic and visual feedback, and data from an acupuncture practice simulator. Radionuclide assessment and diagnosis of acute myocardial infarction. Thermally Strained Band Gap Engineering of Transition-Metal Dichalcogenide Bilayers with Enhanced Light-Matter Interaction toward Excellent Photodetectors. Outside blood vessels it spread along matrix networks of arcs and back-to-back loops. While it is well established that acne can be responsible for depression and low self-esteem, it is likely that this impact is aggravated by the sociological evolution of adolescents in the 21st century. After both 6 and 24 months, small areas of the implant were not covered with tissue.

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Studies have demonstrated that peak oxygen consumption (peak VO2) and the VE/VCO2 slope are predictors of survival in patients with heart failure (HF). This study evaluated the influence of inoculum sources (with various origin) on adaptation of a biogas community and the efficiency of the biomethanization of maize silage. Vaccination is an important component of efforts to control cholera epidemics. The early stage of infection in this model was characterized by a shedding of Chlamydia in vaginal secretions followed by an ascending infection and inflammation in the upper genital tract. Our studies indicate that all of the last five residues of NR2b contribute to the binding selectivity. ARDS is the common pulmonary complication in CAPS, although it rarely occurs in APS.

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Prior to ETS, stellate ganglion blockade was performed in 4 patients to reduce VSA attacks and to confirm the effect of sympathetic blockade. Preoperative thrombocytosis and hyperfibrinogenemia reflected tumor burden to some extent and thus influenced treatment outcomes, and the fibrinogen level was found to be useful as a prognostic predictor in the HGSC patients. Endogenous norepinephrine regulates blood flow to the intact rat tibia. Special emphasis is given to the basic simple ways to improve circulation, vital organ perfusion pressures, and the grave prognosis of sudden cardiac death. The structures of 1 and 4 were elucidated by means of HRMS and NMR spectroscopic methods. In this study, we performed a genomics based discovery of SM biosynthetic gene clusters in Aspergillus ustus, a rare human pathogen. Effect on spasm of a vasopressin antagonist or vasopressin antiserum.

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Uptake of glycerol 3-phosphate and some of its analogs by the hexose phosphate transport system of Escherichia coli. Technology and implications for the use of electric bistoury in prosthetics. Hearing loss (as reflected by abnormal sound detection) is a frequently reported consequence of Type 1 diabetes mellitus. Measurements of ERI at work are valid in terms of responsiveness to organizational changes. Heart failure management: continuing to fail or signs of success?. Past caries experience has been shown to be the best predictor of the development of caries in the future, and clinical observations suggest that caries develops symmetrically in similar teeth on each side of the mouth. 14,813 individuals for all of whom we had a legible recording of their agreement to participate. Iron deficiency decreases mitochondrial aconitase abundance and citrate concentration without affecting tricarboxylic acid cycle capacity in rat liver. Immunohistochemical staining was used to determine the expression of LAPTM4B-35 protein in precancerous gastric lesions and gastric carcinomas. Information Technology and Acute Kidney Injury: Alerts, Alarms, Bells, and Whistles.

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The results showed that the levels of miR-98 were higher, the levels of TSP1 were lower, in B cells isolated from the peripheral blood in patients with asthma. Direct trials comparing high or low doses are rare with potential dose-effect toxicity. A simple automated method of marking multiple-choice questionnaires using a computer. Mutation analysis of KRAS is needed before starting treatment with monoclonal anti-EGFR antibodies in patients with metastatic colorectal cancer (mCRC). We identified randomised controlled trials comparing an early versus a delayed invasive strategy in patients presenting with NSTE-ACS by searching MEDLINE, Cochrane Central Register of Controlled Trials, and Embase. The diagnosis of somnambulism was confirmed polysomnographically and linked etiologically to the start of using metoprolol, a lipophilic beta-blocker, for treating her hypertension. Inhibition of the function of the JNK substrate and AP-1 subunit c-Jun blocked cell death from NF-kappaB inactivation and TNF as determined by measures of cell survival, numbers of apoptotic and necrotic cells, and DNA hypoploidy. Mass-spectrometry and RNA-sequencing methods now enable global profiling of the translatome, but these still involve significant analytical and economical limitations. Hemorrhagic lung foci, weight, and displacement volume were determined, and lungs were examined by light and electron microscopy. We have applied correlative microscopy to identify the key constituents of a dorsal rib fossil from Koreanosaurus boseongensis and its hosting mudstone discovered at the rich fossil site in Boseong, South Korea, to investigate the factors that likely contributed to diagenesis and the preservation of fossil bone.

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Radioclinical and histological analyses of peri-implant tissues show the presence of numerous foreign particles that may come from the implant. The comparative study was performed using traditional correlation of the FKUL values with the retention parameters of the analytes describing the column performance test. Among racial/ethnic minority women, minority sexual orientation is associated with increased health risks. Incidental Finding of Bronchopulmonary Sequestration in a 64-Year-Old Female. If patients fail conservative treatment, surgical management with joint-preserving, deformity-corrective techniques is typically used for pediatric flexible flatfeet in conjunction with deformity-specific soft tissue procedures. Using an instrumental variable approach, we find that middle school transition in grade 6 led to a moderate decrease of 0.04 standard deviations in BMI z-scores for all students. A new electrophoretic technique was used for separation of 10(-7) to 10(-9) gram of protein and radiometric determination of the various protein fractions.

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Bevacizumab treatment resulted in a distinct decrease of blood vessel number. Simple changes in during the procedures in neonatal surgery can reduce the appearance of wound infection and morbidity. A phase 2a randomized, double-blind, placebo-controlled, sequential dose-escalation study to evaluate the efficacy and safety of ASP015K, a novel Janus kinase inhibitor, in patients with moderate-to-severe psoriasis. Vaginal birth after cesarean section in a rural African setting. We present a 23-year-old woman, who was admitted to the hospital because of a palpable abdominal mass and discomfort since 4 months. Forty-two osteoporotic patients with proximal femur fracture and 40 osteoporotic non-fractured age and gender-matched controls were included in the study. Axillary vessel injuries are uncommon and challenging injuries encountered by trauma surgeons. TOB (transducer of ErbB-2) is a tumor suppressor that interacts with protein-tyrosine kinase receptors, including ErbB-2.

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Functional evaluation of a bioartificial pancreas using isolated islets perifused with blood ultrafiltrate. Increased PGI2 activity in venous tissues from rats on oral contraceptives is not prevented by heparin administration before vessel isolation. Furthermore, as recent studies have implied that gene expression patterns are highly tissue specific, it is essential to investigate gene expression in a variety of tissues using RNA-seq. Maternal vaccination with an investigational CRM197-glycoconjugate GBS vaccine elicited higher GBS serotype-specific antibody levels in infants until 90 days of age, compared with a placebo group, and did not affect infant immune responses to diphtheria toxoid and pneumococcal vaccination. TM-3 cells were cultured and treated with varying concentrations of RA for 24h. Pretreatment of the cultures with actinomycin D does not affect the ability of La Crosse virus infection to induce mRNA instability, and examination of the rRNAs shows no evidence of specific degradation due to activation of the interferon-associated latent RNase. The key role played by the radical cation as the intermediate initiator involved in the subsequent propagation cycle has been demonstrated.

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Comparison analysis of distributions of tyrosine hydroxylase, calmodulin and calcium/calmodulin-dependent protein kinase II in a triple stained slice of rat brain. Calcium levels are controlled via a variety of feedback mechanisms and exchangers/transporters. Diagnoses could be modified during the episode of care, and a modified diagnosis was applied to all episode data. We compared the pharmacokinetics (PK) of IA triamcinolone acetonide (TA) delivered as an extended-release, microsphere-based formulation (FX006) vs a crystalline suspension (TAcs) in knee OA patients. To explore whether temporomandibular disorder (TMD) pain patients reporting different levels of pain-related disability differ in terms of illness explanations and treatment expectations. Sustaining care for a parent with dementia: an indefinite and intertwined process. At laparoscopy combined with vaginoscopy hematocolpos was drained following which she improved clinically and CA 19-9 level returned to normal.

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The results showed that AT2R overexpression can inhibit tumor growth of prostate cancer in vivo by inhibiting proliferation and inducing apoptosis of tumor cells. At the ultrastructural level, the VIP cells were characterized by the presence of highly electron dense secretory granules. A concern in the current trend toward more aggressive undermining in rhytidectomy and liposuction surgery has been the potential for damage to the marginal mandibular nerve. Here we demonstrate that a recently developed platform comprised of nanoparticles that release therapeutic levels of nitric oxide (NO-np) inhibits candidal biofilm formation, destroys the extracellular polysaccharide matrices of mature fungal biofilms, and hinders biofilm development on surface biomaterials such as the lumen of catheters. Pharmacogenomics is the study of the impact of genetic variations or genotypes of individuals on their drug response or drug metabolism. This approach offers promising perspectives in the development of metamaterials for elastic waves that involve non-scalar interactions. An approach has been developed to HIV treatment priority setting that simultaneously considers efficiency and the costs of scaling up. Autonomic dysfunction is frequently encountered in patients with EHPVO and cirrhosis, and the presence of autonomic dysfunction in patients with noncirrhotic portal hypertension suggests a primary role of portal hypertension per se in the dysfunction. Despite the use of these treatment modalities, the presence of thyroid metastasis is associated with a very poor can you drink alcohol while taking pyridostigmine prognosis and significant morbidity. The main objective was to design two pharmaceutical dosage forms by using LAPS as active pharmaceutical ingredient and to perform its quality control, in vitro activity conservation tests and human trials (safety evaluation).

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Moreover, those previously exposed to transition preparation efforts were more likely to have motivation and a sense of competence in HCT skills. Conflicting data exist on the risk of stent thrombosis with drug-eluting stents (DES) versus bare-metal stents (BMS). This study examines the types of news stories that include comments by everyday cancer survivors and the messages or information these individuals provide. Kinetic investigations into the possible cause of low serum histidine in rheumatoid arthritis. Assessments of functional capacity were made using the Global Assessment of Functioning (GAF) scale, and each patient was assigned a psychiatric diagnosis using ICD-10 criteria. Acetylcholine release from the cerebral cortex: its role in cortical arousal. This suggests a critical role of 5HT2A receptor signaling in supporting the neural tracking of dynamic tonal structure in music, as well as in supporting the associated increases in emotionality, connectedness, and meaningfulness in response to music that are commonly observed after the administration of LSD and other psychedelics. In the current study, molecular cloning and characterization of PnbHLH1 transcription factor were explored in Panax notoginseng. While it has been made to make such a product commercially available. Endocultivation of Scaffolds with Recombinant Human Bone Morphogenetic Protein-2 and VEGF165 in the Omentum Majus in a Rabbit Model.

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Lung burdens of Ni in mice were approximately one-half that in lungs of rats. Adopting these standards will lead to better communication among researchers and clinicians. In all these situations, SAMS activity is co-ordinated with that of the parasympathetic nervous system, the pituitary-adrenocortical cleocin gel system, and probably several neuropeptide systems. The everyday practice of dentistry relies heavily on achieving adequate local anesthesia. Ultra-processed foods, protein leverage and energy intake in the USA. Our results show a statistically significant superiority of the picosecond lasers compared to the nanosecond laser for tattoo clearance. We solve a unifying analytical model of the strain propagation for acoustic impedance-matched opaque films on a semi-infinite transparent substrate, showing that the lattice dynamics essentially depend on two parameters: One for the spatial profile and one for the amplitude of the strain. The present study indicated that the diversity and composition of gut microbiota were different between the CAD-DM2 and CAD-NDM2 patients.

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We identified many pro-apoptotic genes and partial sequences of previously uncharacterized genes using this method. She was treated with a calcium-channel blocker and magnesium, and there was resolution of her symptoms and cerebrovascular changes. Phosphoproteomics in tenormin cost translational research: a sarcoma perspective. In individuals who are not yet infected, the HBV vaccine is safe and highly effective at preventing disease transmission. Comorbidity of Headache and Depression After Mild Traumatic Brain Injury.

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Fascial sling and the colposuspension were considered standard operations in the therapy of female stress urinary incontinence until the mid-1990s. It behoves us as obstetricians to improve our capabilities in identifying the compromised fetus at term. In cutaneous melanoma, for example, wide excision of the primary tumor site, usually in combination with skin grafting, has been the standard for years. Morphological changes in cells of a culture of amniotic epithelium under the influence of amino derivatives of acridine. Vitamin D supplementation should be considered to prevent from osteomalacia, osteoporosis and future fractures. According to adrenal venous sampling and histopathology, 39 patients were diagnosed as bilateral adrenal hyperplasia (BAH), 37 as aldosterone-producing adenoma (APA), and 19 as unilateral adrenal hyperplasia (UAH). Prevention and control of this hazard depends on removal of one or more of the 3 components. Further, the possibility of applying our model experiments to the formation of natural methane hydrates was discussed. Magnetic resonance imaging scan with contrast reveals an intramedullary lesion in the spinal cord from D8-D10 level.

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Therefore, studies aiming to understand the physiological regulation of glucagon secretion and the corresponding impairment during diabetes are directly relevant to the treatment of type 2 diabetes. The lymphatic system is crucial for efficient immune surveillance and for the maintenance of a physiological pressure in the interstitial space. Optical coherence tomography angiography and indocyanine green angiography for corneal vascularisation. Both the combined inhalation and oral exposures and the single-route exposure through inhalation or ingestion induced centrilobular hypertrophy and single-cell necrosis of hepatocytes, increased plasma levels of alanine aminotransferase (ALT), increased percentage of proliferating cell nuclear antigen (PCNA)-positive hepatocytes without glutathione-S-transferase placental form (GST-P)-positive liver foci, and increased relative liver weight. We hypothesize a cooperative oxygen sensing function by both the kidney and carotid body to ensure maintenance of whole body blood flow and tissue oxygen homeostasis. Photo-induced bending in a light-activated polymer laminated composite. Uncovering exposures responsible for birth season - disease effects: a global study. Prenatal diethylstilbestrol exposure and risk of obesity in adult women. These data have been confirmed by molecular investigation of caspase activity. A measure of cross-brain neural coupling was computed following previously published work to indicate synchronized flow between right temporoparietal junction networks (previously shown to host neural coupling abilities in health).

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Selected in-vitro studies were conducted to address specific issues dealing with mesangial cell (MC) differentiation and composition of extracellular matrix to add additional data to the existing vast literature. The concept of multicellular histogenesis of skeletal muscle fibre is the basis for understanding embryonal genesis of the voluntary muscles as well as muscle fibre regeneration. We undertook a nationwide nested case-control study in New Zealand to examine the risk of AKI without concurrent serious muscle injury according to simvastatin dose in two cohorts: people without a history of renal disease and people with non-dialysis dependent chronic kidney disease. Substrate reactivity as a function of the extent of reaction in the enzymatic hydrolysis of lignocellulose. Our results indicate that GC survivors face diverse problems, both physically and mentally. Phosphaturic activity of urine extracts not associated with parathormone. Forty-two consecutive lung-transplant patients were included in this cross-sectional study. Change in electrical activity and reflex excitability of the spinal cord under the effect of manganese.

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Without creative solutions to this problem, treatment of injuries and infections will become progressively more challenging. The complex anatomy and biomechanics of the acromio-clavicular joint can lead to complications that result in damage to the joint itself or acromial erosion. A systematic review was conducted to compare primary closure with myocutaneous flap reconstruction of perineal defects following abdominoperineal resection or pelvic exenteration with regard to surgical-site complications. Scoring for chondrocyte viability, cartilage surface morphology, and cell and matrix appearance was significantly higher in the vascularized osteochondral group than in the graft group. Extracorporeal dialysis in the therapy of chronic kidney failure. Our results suggest that both contemporary environment processes (present-day abiotic and biotic environment characters) and historical processes (spatial isolation, dispersal limitation occurred in the past) dominate variations of fungal communities in wheat fields, but their relative importance of all these processes depends on the proximity of fungal community to the plant roots.

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Its applications include genomic sequencing, drug resistance testing, microbial characterization, and targeted sequencing in cancer studies. Further research is required to determine if these findings are beneficial or harmful. The production of ccMA was further improved by deletion of the muconate cycloisomerase gene (catB) and by deleting a feedback inhibitor of the aromatic amino acid pathway. Statistical optimization of alpha-amylase production by probiotic Lactobacillus imipramine pamoate brand plantarum MTCC 1407 in submerged fermentation. Identification of trichlormethiazide as a Mdr1a/b gene expression enhancer via a dual secretion-based promoter assay. This article focuses on several critical care aspects of these unstable ACS patients. The amount of prostacyclin generated by the inferior vena cava was much lower than that by the aorta.

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Suture techniques for atrioventricular valves: experimental study. Eculizumab (ECU), a humanized antibody that blocks complement is 1500 mg of depakote too much activity, has been successfully used in aHUS, but the best treatment schedule is not yet clear. Of 706 allegations made against nurses and midwives between January and March of this year, 136 related to patient care. Our results suggest that the ability to synthesize gamma-decalactone is a particularity of the strain A19, since the mesophilic strain (no. The distinct sumoylation dynamics may help extend our understanding of the cell-specific regulation of the molecular basis that promotes cell survival in the hypoxic IVD. To clarify this point, we attempted to develop RBV-resistant cells from RBV-sensitive HCV RNA-replicating cells. In the context of controversy and uncertainty about the role of selective serotonin reuptake inhibitors (SSRIs) for the treatment of depressive disorders in children and adolescents, we consider the evidence of the benefits and risks of this class of medication and the possible role of shared decision-making as a practical way to guide clinicians, young people and their families through treatment decisions. In this perspective we highlight compounds that are apparently incompatible with the more classical (platinum-derived) concepts employed in the development of metal-based anticancer drugs, with respect to both compound design and the approaches used to validate their utility. To analyze an RNA-dependent interaction with chromatin, we purified native nucleosomes from mouse ES cells and detect that Suv39h1 and Suv39h2 exclusively associate with poly-nucleosomes.

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