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Benclamet (Glibenclamide)
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Benclamet

Benclamet belongs to the class of drugs known as sulfonylureas. It lowers blood sugar by causing the release of your body's natural insulin. Benclamet is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. It may also be used with other diabetes medications..

Other names for this medication:
Aviglen, Betanase, Betrol, Bionil, Codica, Comdiab, Daocon, Daonil, Diolin, Duotrol, Dutrol, Giclamide, Glibact, Glibenclamide, Glibet, Glibson, Glifil, Glime, Glinil, Glucomin, Gluconil, Glucored, Glucosafe, Glucosil, Glucotrac, Glybenclamide, Glybid, Glybonil, Glyboral, Glybovin, Glycurb, Glycurub, Glymep, Iscept, Melitus, Metclam, Metica, Monomet, Secrin, Sugatrol, Sugnl, Sugronil, Sycored, Symet, Triglycomet

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Trandate, Nexium, Plaquenil, Requip, Elavil, Aldactone, Albenza, Cleocin

Also known as: Glibenclamide

Description

Benclamet comes as a tablet to take by mouth. It is usually taken once a day with breakfast or the first main meal of the day. However, in some cases your doctor may tell you to take Benclamet twice a day. To help you remember to take Benclamet, take it at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Benclamet exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor will probably start you on a low dose of Benclamet and gradually increase your dose if needed. After you have taken Benclamet for some time, Benclamet may not control your blood sugar as well as it did at the beginning of your treatment. Your doctor may adjust the dose of your medication as needed so that the medication will work best for you. Be sure to tell your doctor how you are feeling and if your blood sugar test results have been higher or lower than normal at any time during your treatment.

Benclamet helps control blood sugar but does not cure diabetes. Continue to take Benclamet even if you feel well. Do not stop taking Benclamet without talking to your doctor.

Dosage

Usual Adult Dose for Diabetes Type 2:

Standard Benclamet: -Initial dose: 2.5 mg to 5 mg orally once a day -Dose titration: Increase in increments of no more than 2.5 mg at weekly intervals based upon blood glucose response -Maintenance dose: 1.25 to 20 mg orally as a single dose or in divided doses -Maximum dose: 20 mg/day Micronized Benclamet: -Initial dose: 1.5 mg to 3 mg orally once a day -Dose titration: Increase in increments of no more than 1.5 mg at weekly intervals based upon blood glucose response -Maintenance dose: 0.75 to 12 mg orally as a single dose or in divided doses -Maximum dose: 12 mg/day Comments: -Administer with breakfast or the first main meal of the day -Lower initial doses may be used in patients who are sensitive to hypoglycemic drugs -Once a day therapy is generally satisfactory, however, some patients may have a more satisfactory response with twice-a-day dosing, especially those receiving higher doses. TRANSFER FROM OTHER HYPOGLYCEMIC THERAPY: -Oral Antidiabetic Therapy: No exact dosage relationships exists between standard Benclamet, micronized Benclamet, or other oral hypoglycemic agents; when transferring patients from other oral hypoglycemic therapy, the maximum starting doses should be observed. -Insulin: --If the insulin dose is less than 20 units per day substitute 2.5 to 5 mg (standard) OR 1.5 to 3 mg (micronized) orally once a day. --If the insulin dose is between 20 and 40 units per day, substitute 5 mg (standard) OR 3 mg (micronized) orally once a day. --If the insulin dose is more than 40 units per day; transition the patient by concomitantly decreasing insulin by 50% and starting Benclamet at 5 mg (standard) OR 3 mg (micronized) orally once a day; as insulin is progressively withdrawn, titrate in increments of 1.25 to 2.5 mg (standard) OR 0.75 to 1.5 mg (micronized) orally once a day every 2 to 10 days. Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Usual Geriatric Dose for Diabetes Type 2:

Initial dose: 1.25 to 2.5 mg (standard) orally or 0.75 to 1.5 mg (micronized) orally once a day.

Detailed Benclamet dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A Benclamet overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, nausea, tremors, sweating, confusion, trouble speaking, fast heartbeats, or seizure.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Side effects

The most common side effects associated with Benclamet are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

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RNA regulation went wrong in neurodevelopmental disorders: The example of Msi/Elavl RNA binding proteins. It might be hypothesized that leptin may be an active factor in the pathogenesis of PCOS and endometriosis, which are two major causes of primary infertility. Antibodies that target IL-31, in particular, its receptor A, showed interesting results in atopic dermatitis and decreased pruritus. leprae in each hind foot pad were subjected to nerve conduction velocity studies followed by light and electron microscopy and fibre tease of both sciatic nerves at sequential time intervals from the 4th to the 24th month. The conversation was videotaped and analyzed for the use of nonverbal communication between aphasic and partner. Two Active Pharmaceutical Ingredients (APIs) with significant differences in aqueous solubility have been chosen for this study, namely aripiprazole and desvenlafaxine (see Figure 1). Somatic lamins in germinal vesicles of goldfish (Carassius auratus) vitellogenic oocytes. Analyzing the activation of the DNA damage response (DDR) in various yeast mutants or growth conditions, as well as its consequences for cell cycle progression and cell viability over extended periods of time therefore requires a special microscopy setup that does not by itself create DNA damage or perturb cell growth.

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DNA damage that alters protein/DNA interactions therefore has the potential to disrupt normal cellular functions including proliferation. Updated recurrence risks figures are presented for genetic counseling of families with a congenital heart defect (CHD) in a first-degree relative. We demonstrated higher risk of dose-limiting toxicity and overall mortality for metastatic renal cell cancer patients with low versus high skeletal muscle index or skeletal muscle radiodensity, but observed inconsistent associations with visceral adipose tissue and perinephric fat. In 342 outpatients with AECOPD, we compared detection rates of H. On the basis of the currently available literature, there is a low scientific evidence of a benefit related. It has been shown that pretreatment with single-dose oxygen (0.5 to six hours) could reduce CP-induced renal toxicity in rats.

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Unsupervised self-care predicts conduct problems: The moderating roles of hostile aggression and gender. We further extended our finding by showing that the same residues are also crucial for the interaction of DHHC17 with Huntingtin, one of its most physiologically relevant substrates. School enrollment rates were similar between pairs of households. Although not a particularly common event, it is, nevertheless, reported in the literature. In this paper, we aim at analyzing the approximation abilities of shallow networks in reproducing kernel Hilbert spaces (RKHSs). However, the application was constrained by poor transfection efficiency and safety concerns. Content analysis with deductive and inductive coding methods was used to uncover common themes in each dimension of attachment. Analysis of crops and soils for residues of chlorfenvinphos insecticide and its breakdown products. Age-adapted recall and assessment strategies in younger participants may need to be considered to improve PS in younger women.

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Numerous studies have investigated the best method of selecting the appropriate size of endotracheal tube (ETT) for children. In the scales of masculinity, MF-GID individuals scored as male controls, but lower than female controls. Effects of dl-3-n-butylphthalide(dl-NBP) on changes of regional cerebal blood flow (rCBF) and blood-brain barrier of rats subjected to subarachnoid hemorrhage (SAH) were investigated. Students indicate low levels of negative attitudes and moderate levels of positive attitudes. A study of the secondary structure of ilamycin B(1) by 300 MHz proton magnetic resonance. EGFR-activating mutations, DNA copy number abundance of ErbB family, and prognosis in lung adenocarcinoma.

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The effects of telencephalic pallial lesions on spatial, temporal, and emotional learning in goldfish. PRF is a safe and function sparing non-invasive pain palliation method for knee osteoarthritis in elders with cardiac comorbidity. Genomic copy number alterations as predictive markers of systemic recurrence in maxolon dose mims breast cancer. Serum levels of nimodipine in enteral and parenteral administration in patients with aneurysmal subarachnoid hemorrhage. Site-directed mutagenesis was used to replace SEC zinc binding ligands with alanine. In contrast, OXT release within the PVN and the central amygdala correlated positively with the level of maternal aggression. Five thousand five hundred nine studies were identified by the database search, 426 used resilience psychometrics, and six psychometric analysis studies were included in the final analysis. The reduction is faster the smaller the size of the DNA molecule in the mature phage. These data indicate a higher burden of AKI than previously described. However, few studies have quantitatively linked these developmental dynamics to traits that reevolve.

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