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Betrol (Glibenclamide)

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Betrol is an inexpensive drug that helps to treat type 2 diabetes. It is slightly less popular than comparable drugs. Betrol is only available as a generic drug; all brands have been discontinued. Betrol is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.

Other names for this medication:
Afdiex, Aviglen, Benclamet, Betrol, Bionil, Codica, Combidos, Comdiab, Daocon, Diabetnil, Diabetrol, Diolin, Eumet, Glibenclamide, Glibson, Glimsug, Glitrac, Glucomin, Glucosafe, Glucosil, Glucotrac, Glunil, Glutowin, Glybenclamide, Glyboral, Glybovin, Glybovine, Glycurb, Glymep, Iscept, Melitus, Metclam, Metica, Monomet, Sugatrol, Sugnil, Sugronil, Sycored, Triglucored, Triglycomet

Similar Products:
Cardura, Mysoline, Adalat, Dulcolax, Duricef, Zanaflex, Provigil, Ticlid, Flomax, Ovral

Also known as: Glibenclamide


Betrol is used to treat high blood sugar levels caused by a type of diabetes mellitus (sugar diabetes) called type 2 diabetes. In type 2 diabetes, your body does not work properly to store excess sugar and the sugar remains in your bloodstream. Chronic high blood sugar can lead to serious health problems in the future.

Proper diet is the first step in managing type 2 diabetes, but often medicines are needed to help your body. Betrol belongs to a class of medicines called sulfonylureas. It causes your pancreas to release more insulin into the blood stream. This medicine may be used alone or with another oral medicine such as metformin.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet


Usual Adult Dose for Diabetes Type 2:

Standard Betrol: -Initial dose: 2.5 mg to 5 mg orally once a day -Dose titration: Increase in increments of no more than 2.5 mg at weekly intervals based upon blood glucose response -Maintenance dose: 1.25 to 20 mg orally as a single dose or in divided doses -Maximum dose: 20 mg/day Micronized Betrol: -Initial dose: 1.5 mg to 3 mg orally once a day -Dose titration: Increase in increments of no more than 1.5 mg at weekly intervals based upon blood glucose response -Maintenance dose: 0.75 to 12 mg orally as a single dose or in divided doses -Maximum dose: 12 mg/day Comments: -Administer with breakfast or the first main meal of the day -Lower initial doses may be used in patients who are sensitive to hypoglycemic drugs -Once a day therapy is generally satisfactory, however, some patients may have a more satisfactory response with twice-a-day dosing, especially those receiving higher doses. TRANSFER FROM OTHER HYPOGLYCEMIC THERAPY: -Oral Antidiabetic Therapy: No exact dosage relationships exists between standard Betrol, micronized Betrol, or other oral hypoglycemic agents; when transferring patients from other oral hypoglycemic therapy, the maximum starting doses should be observed. -Insulin: --If the insulin dose is less than 20 units per day substitute 2.5 to 5 mg (standard) OR 1.5 to 3 mg (micronized) orally once a day. --If the insulin dose is between 20 and 40 units per day, substitute 5 mg (standard) OR 3 mg (micronized) orally once a day. --If the insulin dose is more than 40 units per day; transition the patient by concomitantly decreasing insulin by 50% and starting Betrol at 5 mg (standard) OR 3 mg (micronized) orally once a day; as insulin is progressively withdrawn, titrate in increments of 1.25 to 2.5 mg (standard) OR 0.75 to 1.5 mg (micronized) orally once a day every 2 to 10 days. Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Usual Geriatric Dose for Diabetes Type 2:

Initial dose: 1.25 to 2.5 mg (standard) orally or 0.75 to 1.5 mg (micronized) orally once a day.

Detailed Betrol dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can cause severe hypoglycemia or lactic acidosis.


Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website ( for more information if you do not have access to a take-back program.

Side effects

The most common side effects associated with Betrol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of Betrol in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving Betrol.

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We thus conclude that intraoperative application of this single probe measurement might help to identify chromaffine tumor cells that have not been located fully by CT. However, their potency in inducing allogeneic T cell proliferation was also less than that of normal monocyte-derived DCs. It poses a risk of complications in children with cardiac disease. Deep venous thrombosis (DVT) offers a high risk of morbidity and mortality, especially in case of pulmonary embolism. While secretion of serous and mucinous components into the bile was long considered as the main function of PBG, recent studies have identified PBG as an important source for biliary epithelial cell proliferation and renewal. Expert opinion: Novel agents of known antimicrobial classes have been developed that demonstrate treatment options in CAP and in AECOPD. The effects of N(G)-monomethyl-L-arginine (NMMA), polymyxin B and cytokines (IFN-gamma, TNF-alpha, IL-4 and IL-12) on the production of NO were also determined. Physically Realizable Space for the Purity-Depolarization Plane for Polarized Light Scattering Media.

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Intracellular Tenofovir-Diphosphate and Emtricitabine-Triphosphate in Dried Blood Spots following Directly Observed Therapy: the DOT-DBS Study. By comparison to pads/tampons (usual product used), the MC was rated significantly better for comfort, quality, menstrual blood collection, appearance, and preference. The PER and POR showed reciprocal connectivity with all prefrontal regions examined, but the patterns of connections differed. Collagen denaturation was correlated with organic matrix-bound water, suggesting that denaturation of collagen to gelatinous form may expose more binding sites to water by unwinding the triple alpha chains. 30 patients with deep vein thrombosis were treated with a combination of urokinase and heparin.

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Possible simulation of intrabronchial tumors with foreign bodies. Phasic functional deterioration of an aortic valve caused by ball deformation. For most diseases, single biomarkers do not have adequate sensitivity or specificity for practical purposes. Free flowing dry proniosomal powder are suitable for unit dosage forms such as tablet and capsules. Inferring Methionine Sulfoxidation and serine Phosphorylation crosstalk from Phylogenetic analyses. In this review, we explore the increasing proposed uses for SADs and discuss possible complications and the management of these. Here, we present a semi-quantitative MALDI-TOF MS-based approach for the detection of resistance in different species against different antibiotics. CsCl, CaCl2, Na2MoO4, NiCl2, K2PtCl4 increased the frequency of diploid spores, while NaWO4, VOSO4, KCl, BaCl2 already increased recombination frequency.

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Global transcriptional analysis of Escherichia coli expressing IrrE, a regulator from Deinococcus radiodurans, in response to NaCl shock. Use of sequential MDMA doses is associated with ultram pill lasting decreases in brain SERT, but not DAT. Twelve healthy, nonsmoking women (mean age: 21.7 years) were recruited from the family planning clinic of the university hospital Zurich. A compound accounting for the mutagenic activity has been isolated by high performance liquid chromatography. Utilizing Task Shifting to Increase Access to Maternal and Infant Health Interventions: A Case Study of Midwives for Haiti. In both the 1996 and the 2006 studies, a shift in identity occurred, and removal centered around dissociating from the past. Short- and long-term effects of oxytocin on quality and quantity of semen from rams. The purpose of this study was to evaluate whether serum levels of MKRN3 declined before pubertal onset in healthy girls. This activation resulted in a subtype of macrophages with pro- but also anti-inflammatory properties.

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These ideas suggest the convenience of a more systematic use of field homology methods, which start with appropriately identified developmental fields to expand knowledge on adult homology (sameness) and eventually also on accessory structural and functional similarities or differences. The aim of this study was to assess the mammographic appearance of screening-detected breast carcinoma with the basal phenotype. This finding suggested breed differences in the development of the hypothalamic-pituitary-ovarian circuit. Our results provide clinicians, administrators and policy-makers with knowledge of the environmental impact of their decisions to facilitate adoption of sustainable practices. DCs transfected with the total RNA content of autologous tumor cells stimulated antigen-specific T-cell responses that are capable of recognizing and lysing autologous, primary tumor cells in vitro. We also found high expression of HSP90 and the PI3K/AKT/mTOR pathway proteins, 4EBP1 and AKT compared with healthy tissue and this correlated with poor overall survival of melanoma patients. Quantitative techniques, which are able to investigate both skin morphology and penetration processes, are also reviewed. A follow-up investigation of 39 antisocial children 4-20 years after discharge from hospital.

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Implants delivering bisphosphonate locally increase periprosthetic bone density in an osteoporotic sheep model. Here we show that the above phage mutant is also defective in the expression of phage-coded deoxyribonuclease (DNase) at 42 degrees C but not at 32 degrees C. Vascular superoxide production was quantified in both saphenous veins and internal mammary arteries from 45 diabetic and 45 side effects of aygestin 5 mg matched nondiabetic patients undergoing coronary artery bypass surgery. After 2 rounds of Delphi process, the task force concluded by unanimous consensus and with the highest level of confidence that a vial of toxin reconstituted appropriately can, for facial muscle indications, be (1) refrigerated or refrozen for at least 4 weeks before injection without significant risk for contamination or decreased effectiveness and (2) used to treat multiple patients, assuming appropriate handling. To investigate the possible causes of plagiocephaly in infants and the therapeutic effect of postural correction training on plagiocephaly. In particular, where the plasmonic hot holes participate in water oxidation is still illusive. This model might be used to develop screening and prevention strategies.

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The allosteric activation by F-2,6-P(2) appeared to be entirely abrogated in the mutated enzymes confirming our predictions. The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut. Given the results about the metabolic profile, silybin, modulator of GLUTs, was selected as potential candidate to overcome doxorubicin resistance and, intriguingly, data revealed not only that silybin is more active in resistant cells than in wild type cells, but also that the combined treatment with doxorubicin and silybin presents a synergistic effect in LoVo DOX cells. A huge variety of potential target structures have been identified, many of which are already being exploited for therapeutic purposes. Circulating IgG antibody titers to all PCV7 and PPV23-only serotypes 2, 5 and 7F were measured before and after challenge with 1/5th of a normal PPV23 dose. The present study demonstrates that KCCP and its fraction PII have antioxidant properties that may help fight cancers.

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The primary analysis comprised 761 patients who completed 5 years follow up, obtained from the prospective South London Stroke Register (1998-2013). Differences in distance and stride profile between both feet were larger at home, than in clinic. To determine the outcome of application of amniotic graft in ocular surface disorders. Serum concentrations of doxycycline were determined before and at various intervals after administration. Quantitative and fingerprinting analysis of Pogostemon cablin based on GC-FID combined with chemometrics. From an analysis perspective, there are several ways to approach RNA-seq data to unravel differential transcript usage, such as annotation-based exon-level counting, differential analysis of the percentage spliced in, or quantitative analysis of assembled transcripts.

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Firstly, this is because venous PO2 and PCO2 values do change appropriately in proportion to metabolic rate, so a metabolic rate signal sufficient to drive breathing might already exist. Prevalence of laparoscopic surgical treatment and its clinical outcomes in patients with familial adenomatous polyposis in Japan. It promoted increased number of home-based death, appropriate and early hospice referral, and averted needless hospitalization. Characterization of aygestin drug classification lymphocyte binding to antigen-pulsed macrophage monolayers. The rise of black phosphorus (BP) as a new family member of two-dimensional (2D) materials brings new concepts and applications to the field, because of the infrared band gap and anisotropic properties of such materials. A high molecular weight glycoprotein (450,000) was obtained from thrombin-treated duck thrombocytes by barium citrate adsorption technique followed by heparin-agarose affinity chromatography.

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Symptoms were poorly localized in all these IPS osteomyelitis patients. Palladium-catalysed biscyclisation of allenic bromoalkenes through a zipper-mode cascade. Survey of Provider Preferences Regarding the Route of Misoprostol for Induction of Labor at Term. A theoretical model based on density functional theory (DFT) calculations suggests that both a vibrational Stark effect and bias-induced charging of the junction contribute to the shifts in vibrational energies. However, unlike imidazole, cyanide exerts less significant perturbation on the conformation of the heme cavity, which is revealed by a more compact residue package in the distal pocket. With the use of appropriate equipment for each patient, exercise testing can be done safely and effectively in musculoskeletally handicapped individuals. Few interventions address social and structural barriers to HIV prevention, such as stigma, discrimination, and poverty. Our results are in line with those previously reported and call attention to the issue of tumor clonality in this kind of treatment. Standard strains of the micro-organisms were obtained from ATCC (American Type Culture Collection) and MTCC (Microbial Type Culture Collection) which comprised of Streptococcus mutans MTCC no.

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This study demonstrates the biologic relevance of the SLE risk haplotype of IRF5 at the protein level. Cerebral radionecrotic lesions were diagnosed 6 months to 14 years after irradiation, and were inconstantly associated with clinical symptoms. We employ constant-temperature and replica exchange molecular dynamics to survey the free energy landscape of the ccbeta peptide using a united-atom potential and an implicit solvent representation. Visualization of the molecular details of these processes reveals several scientific questions about how molecular components of the pneumococcal cell are organized to allow biological function to take place. All other STR-profiles of remaining 15 patients analysed in this study are stable over all passages and freeze-thaw processes. Cleavage of the fourth component of human complement (C4) by C1 esterase: isolation and characteristics of the low molecular weight product. Microplastics in livers of European anchovies (Engraulis encrasicolus, L.). Structure of Bacillus stearothermophilus: an electron microscope study. These data suggest a role for transient depletion and/or dysfunction of cellular receptors of insulin activity in the evolution of insulin resistance in diabetes. Multiple insulin secretory defects are present, including absence of pulsatility, loss of early phase of insulin secretion after glucose, decreased basal and stimulated plasma insulin concentrations, excess in prohormone secretion, and progressive decrease in insulin secretory capacity with time.

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Genome-wide analysis of transposon insertion polymorphisms reveals intraspecific variation in cultivated rice. The incidence of ADL disability, and mobility difficulty were 2.7 (2.5-2.8), and 9.8 (9.4 -10.3) events per 100 person years. When testing normal target susceptibility patterns, RNK-16 kills lymphoblasts of B type better than T blasts, which is well in line with previous findings on normal NK cell specificity patterns. Based on our findings, we recommend that nutrition training programs in Cameroon be redesigned to make them more responsive to the public health needs of the country. However, in spite of few clinical data, the use of dual release hydrocortisone can be extremely favorable ACTH deficiency, which is associated with an increase of overall and cardiovascular mortality, also due to the risk of overtreatment. The above results suggested that the rs1878406 polymorphism of endotheline receptor gene may serve as a genetic marker for severe multi-vessel disease in CHD among ethnic Han Chinese. (4) To present the best estimate of the cost-effectiveness threshold for policy purposes. Experience at Duke Medical Center after modern legislation for therapeutic abortion. The history and development of ophthalmic plastic and reconstructive surgery in Canada. The results show a moderate negative correlation amaryl tab uses between innervation density and the increase of FR with light touch.

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A waterborne outbreak involving hepatitis A virus genotype IA at a residential facility in the Republic of Korea in 2015. Bacterial endophytes ubiquitously colonize the internal tissues of plants, being found in nearly every plant worldwide. Clinical examination of the affected 10-year-old Turkish boy showed typical features of LHON. This case-control study was performed on 200 pregnant women at third trimester of pregnancy between 2012 and 2013. The neonates had signs of low flow pulmonary, confirmed by echocardiogram. The present paper addresses the gyro-water-bag model derived as a water-bag-like weak solution of the Vlasov gyrokinetic models.

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