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Bonetuf (Calcitriol)

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Bonetuf is a hormonally-active, synthetic vitamin D analog prescribed to treat hypocalcemia, osteoporosis, and the prevention of corticosteroid-induced osteoporosis. Systemic Bonetuf is FDA indicated to control hypocalcemia in patients on chronic renal dialysis, secondary hyperparathyroidism in those with chronic kidney disease not yet on dialysis, and hypocalcemia in patients with hypoparathyroidism and pseudohypoparathyroidism.

Other names for this medication:
Admax, Alphadol, Apcical, Arachitol, Arcium, Aristrol, Bonetuf, Calasto, Calbory, Calcibest, Calcirol, Calcit, Calcitriol, Caldikind, Calgel, Calosto, Calotec, Caltop, Calzem, Carcal, Cholical, Citroj, Coecoral, Devita, Dmcal, Duracal, Estovon, Ikmag, Laretol, Lctrol, Netxod, Nutribone, Ostriol, Politrol, Qpcal, Riecal, Rockbon, Rolsical, Romical, Septriol, Sorvate

Similar Products:
Pamelor, Caverta, Fosamax, Zithromax, Aygestin

Also known as: Calcitriol


Generic Bonetuf is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Bonetuf are intestine and bone. Generic Bonetuf receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Bonetuf may also act on the kidney and the parathyroid glands. Generic Bonetuf is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Bonetuf has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Bonetuf, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Bonetuf in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Bonetuf produces other independent beneficial effects. Bonetuf is also known as Calcitriol. Generic Bonetuf treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Bonetuf is Calcitriol. Brand name of Generic Bonetuf is Bonetuf.


This section provides information on the proper use of a number of products that contain vitamin d and related compounds. It may not be specific to Bonetuf. Please read with care.

For use as a dietary supplement:

Do not take more than the recommended daily amount. Vitamin D is stored in the body, and taking too much over a period of time can cause poisoning and even death.

If you have any questions about this, check with your health care professional.

For individuals taking the oral liquid form of this dietary supplement:

This preparation should be taken by mouth even though it comes in a dropper bottle. This dietary supplement may be dropped directly into the mouth or mixed with cereal, fruit juice, or other food.

While you are taking alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, doxercalciferol or paricalcitol , your health care professional may want you to follow a special diet or take a calcium supplement. Be sure to follow instructions carefully. If you are already taking a calcium supplement or any medicine containing calcium, make sure your health care professional knows.

The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For alfacalcidol To treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For parenteral dosage form (injection): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 12 mcg a week. To treat diseases in which calcium is not used properly by the body: For oral dosage form (capsules): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 0.25 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day.

For calcifediol To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults, teenagers, and children over 10 years of age—At first, 300 to 350 micrograms (mcg) a week, taken in divided doses either once a day or every other day. Your doctor may change your dose if needed. Children 2 to 10 years of age—50 mcg a day. Children up to 2 years of age—20 to 50 mcg a day. To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage forms (capsules and solution): Adults, teenagers, and children—At first, 0.25 micrograms (mcg) a day. Your doctor may change your dose if needed. For parenteral dosage forms (injection): Adults and teenagers—At first, 0.5 mcg injected into a vein three times a week. Your doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For dihydrotachysterol To treat diseases in which calcium is not used properly by the body: For oral dosage forms (capsules, solution, or tablets): Adults and teenagers—At first, 100 micrograms (mcg) to 2.5 milligrams (mg) a day. Your doctor may change your dose if needed. Children—At first, 1 to 5 mg a day. Your doctor may change your dose if needed.

For doxercalciferol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—10 micrograms (mcg) three times weekly at dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For ergocalciferol The amount of vitamin D to meet normal daily recommended intakes will be different for different individuals. The following information includes only the average amounts of vitamin D. To prevent deficiency, the amount taken by mouth is based on normal daily recommended intakes: For oral dosage form (capsules): For the U.S. Adults and teenagers—5 to 10 micrograms (mcg) (200 to 400 Units) per day. Pregnant and breast-feeding females—10 mcg (400 Units) per day. Children 4 to 10 years of age—10 mcg (400 Units) per day. Children birth to 3 years of age—7.5 to 10 mcg (300 to 400 Units) per day. For Canada Adults and teenagers—2.5 to 5 mcg (100 to 200 Units) per day. Pregnant and breast-feeding females—5 to 7.5 mcg (200 to 300 Units) per day. Children 7 to 10 years of age—2.5 to 5 mcg (100 to 200 Units) per day. Children 4 to 6 years of age—5 mcg (200 Units) per day. Children birth to 3 years of age—5 to 10 mcg (200 to 400 Units) per day. To treat deficiency: Adults, teenagers, and children—Treatment dose is determined by prescriber for each individual based on severity of deficiency. To treat diseases in which calcium and phosphate are not used properly by the body: Adults and teenagers—At first, 1000 to 500,000 Units a day. The doctor may change your dose if needed. Children—At first, 1000 to 200,000 Units a day. The doctor may change your dose if needed.

For paricalcitol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—1 to 2 micrograms (mcg) one time per day or 2 to 4 mcg three times a week (not more often than every other day). The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor. For parenteral dosage form (injection): Adults—0.04 to 0.1 micrograms (mcg) per kg no more than every other day during dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.


If you overdose Generic Bonetuf and you don't feel good you should visit your doctor or health care provider immediately.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Bonetuf are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Problems in children have not been reported with intake of normal daily recommended amounts. Some studies have shown that infants who are totally breast-fed, especially with dark-skinned mothers, and have little exposure to sunlight may be at risk of vitamin D deficiency. Your health care professional may prescribe a vitamin/mineral supplement that contains vitamin D. Some infants may be sensitive to even small amounts of alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, or ergocalciferol. Also, children may show slowed growth when receiving large doses of alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, or ergocalciferol for a long time.

Studies on doxercalciferol or paricalcitol have been done only in adult patients, and there is no specific information comparing the use of doxercalciferol or paricalcitol in children with use in other age groups.


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Need for a standardized protocol for stress echocardiography in provoking subaortic and valvular gradient in various cardiac conditions. Sabellaria jeramae, a new species (Annelida: Polychaeta: Sabellariidae) from the shallow waters of Malaysia, with a note on the ecological traits of reefs. Reversible blocking of peripheral inputs and writing in patients with cerebellar tremors. To compare the therapeutic effect between endoscopic thyroidectomy and open thyroidectomy. Patients with primary complicated and recurrent pilonidal sinus received a fasciocutaneous V-Y advancement flap in the general surgery service of our hospital. Disease recurrence was diagnosed by biopsy (protocol or clinical), and follow-up was monitored by laboratory parameters and protocol biopsies. A brief guide to designing effective figures for the scientific paper. Incompatibility of lyophilized inactivated polio vaccine with liquid pentavalent whole-cell-pertussis-containing vaccine. Surgical margins were positive, and histopathology demonstrated bland spindle cells with stromal overgrowth. The absence of differences between women with fractures and those with very low BMD indicates that this distinction may not be clinically useful to categorize young women with osteoporosis.

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Over a 2-year period, a total of 389 MRSA-related claims were reported to the BGW, of which 17 cases with infections were recognized as an OD. It has been recognized for centuries that posture and health are interrelated. Yeast methylotrophy and autophagy in a methanol-oscillating environment on growing Arabidopsis thaliana leaves. High levels of anti-cyclic citrullinated peptide autoantibodies are associated with co-occurrence of pulmonary diseases with rheumatoid arthritis. Interrelationship analysis indicated a statistically significant negative correlation between the cranial base angle (NSAr) and the angles of maxillary (SNA) and mandibular (SNB) prognathism, as well as a positive correlation between the angle of inclination of the ramus to the cranial base (GoArNS) and the angle of sagittal intermaxillary relationships (ANB). A framework for structural equation models in general pedigrees. Bacterial biofilm and allergic inflammation are important factors resulting into refractory chronic rhinosinusitis.

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A Method for Lineage Tracing of Corneal Cells Using Multi-color Fluorescent Reporter Mice. Neurons are tree-like structures whose description depends critically on the junctions and terminations, collectively called critical points, making the correct localization and identification of these points a crucial task in the reconstruction process. Of 22 neurons with well-filled dendrites, 16 had smooth dendrites, two had sparsely spiny dendrites (less than 200 spines) and, unexpectedly, four had spiny dendrites typical of pyramidal cells. donovani gene recognized by the LEMDR06 polymerase chain reaction product, ldmdr1, was isolated from a genomic library, transfected into wild-type cells, and amplified over 500-fold by selection in 0.5 mg of G418 per ml. At 5 years, the age-standardised Ederer II estimator performed equally well as the Pohar Perme estimator with the exception of melanoma in which the Pohar Perme estimator had a smaller mean squared error (MSE). Granuloma annulare (GA) is a noninfectious necrobiotic granuloma, which can present as localized or generalized patterns. The industrial-grade silicon contaminated by additives may remain dormant for years and eventually cause formation of extensive granulomas and disfiguring nodules. Inhibitory actions of prostaglandin E1 on neurogenic plasma extravasation in rat airways.

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Because of the possible annihilation of lattice sites and accompanying clustering, the system moreover shows an unusual softening upon compression. Altering tissue culture media components to increase ECIF and/or transformation frequency (TF) has been one approach used to expand the range of maize genotypes amenable to genetic transformation using the IZE. Post-translational modifications of axonal proteins such as phosphorylation of neurofilaments occur in NLWM and may precede demyelination. Using Northern blot technique, the oncogene expression in normal pancreatic tissue and human pancreatic carcinoma PC-2 and PC-3 cell lines was studied. A benefit in PFS often does not translate into overall survival improvement, largely because of crossover and postprogression therapies. In an additional series of studies, we found that the swollen late endosomes induced by wortmannin are unable to retain previously accumulated fluorescent probes or photosensitizers. We investigated p53 gene alterations in 10 human myeloma cell lines (HMCL), half of these being dependent upon exogenous interleukin 6 (IL-6) for in vitro growth, similar to freshly explanted myeloma cells. We therefore used a molecular genetic approach and found that PTP was unaffected when all calcium-dependent PKC isozymes were eliminated.

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The proposed revisions would: (1) Permit the Regional Medical Libraries to recover part or all of the costs of providing photocopies of biomedical materials, (2) improve readability of the regulations, (3) update references to statutory authorities and uniform administrative requirements, and (4) revoke Part 63 (Traineeships) which is obsolete. Selection of cytoadherent cells from a mixed population co-selects for those with an undeleted chromosome 9 and the selected cells produce gametocytes. Jog Your Mind is a community-based program aiming at empowering elderly people to maintain their cognitive abilities using a multi-strategic approach including cognitively stimulating activities, mnemonic strategies, and strategies to promote healthy behaviors. Establishment and characterization of a new human colon adenocarcinoma cell line: BCS-TC2. In this protocol we provide guidelines to maximize the potential for uncovering single nucleotide variants that drive resistance using adherent lines. A total of 319 stool samples were collected from healthy children in the 10 entrance ports. We found a positive association between RIME and clinical evaluation scores, suggesting that RIME is a valid clinical evaluation instrument. Although the average animal weight increased during the study, this change was not significantly different between the two groups. Recognition of walking stance phase and swing phase based on moving window. Interhemispheric functional connectivity was assessed for each participant by correlating homologous regions using a Pearson correlation coefficient.

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Different texture parameters have been shown to be predictive of the nature of disease and of patient outcome. The goal of the exercise was to correctly discover re-associations and family matches. Bax protein expression was detected by western blot to investigate the underlying mechanism. Williams-Beuren syndrome is caused by a chromosome 7q11.23 deletion in a region containing 28 genes, with the gene encoding elastin situated approximately at the midpoint of the deletion. From these results, it is quite likely that 6R-BH4 plays an important role in the regulation of neuronal activity, as a modulator of neurotransmitter release as well as a cofactor for hydroxylases. Multi-block analysis coupled to laser-induced breakdown spectroscopy for sorting geological materials from caves. Surgeon-dependent factors such as optimal implant alignment are thought to play a significant role in outcome following primary total knee arthroplasty (TKA).

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The rates for men were generally higher, with 40.07 standardized ACD per 100,000. Over the past 20 years the nicotinic acetylcholine receptor has become the prototype of a superfamily of ligand-gated ion channels. Histologic examination of the palatal and breast lesions showed chronic granulomatous inflammation. The recombinant prokaryotic expression vector pGEX-4T-1-GRP78 has been constructed successfully. Flash visual evoked potentials are unreliable as markers of ICP due to high variability in normal subjects. The Derivo Embolization Device provides excellent occlusion of elastase-induced aneurysms while preserving branch arteries. It can provide accurate and reliable measurements of chamber size and function. In vitro cytotoxic activity guided essential oil composition of flowering twigs of Stevia rebaudiana. The protein kinase C inhibitor methylselenic acid induced MICA/B surface expression but dominantly blocked ULBP2 surface transport. Mechanisms underlying differential food allergy response to heated egg.

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A battery of monoclonal anti-cytokeratin-specific antibodies and anti-vimentin were used. Studies of a peptide model of CFTR indicate that the delta F508 mutated region is more sensitive to denaturating conditions. In this regard, the relevant site of action for these compounds is compartmentalized to the distal nephron. miR-148b-3p has been reported to have a vital role in regulating tumor progression. With the increasing cost of medical education and healthcare, medical schools the world over are trying to contain expenditure on the teaching of the basic sciences.

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To investigate the efficiency of secretion in Streptomyces, a construction was made that can you push zofran 8 mg substituted a native Streptomyces beta-galactosidase signal sequence for the Flavobacterium signal sequence. Changes of M1 function may thus underlie impaired motor control of lumbopelvic spine and pain persistence in CLBP. Mounting evidence implicates deregulated ephrin function in multiple aspects of tumor biology. However, the substrate ranges of the Bph enzymes of two strains used were different from each other. Further, we observed significantly higher levels of miR-205 in tumor tissue of esophageal squamous cell carcinoma.

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Triacylglycerol synthesis by microsomal fractions from olive cultures. Intraoperative antifibrinolytic use significantly decreases need for postoperative blood transfusions. A load-dependent increase in PRT was observed, with PRT in the 2KG condition being significantly greater than in the NL condition, and PRT in the 5KG and 10KG conditions being significantly greater than in the 2KG condition. Radiographs and CT scan showed radio-opaque device in the lower abdomen zyrtec 10 mg with small bowel obstruction. The more frequent signs and symptoms were cough, dyspnea, fever and wheezing. In this paper, we found that high level of IL-8 was constitutively present both in familial adenomatous polyposis (FAP) tissue and carcinoma tissue. Patient-related factors (older age, higher ASA score, presence of anemia, and lower serum albumin) and procedure-related factors (performance of combined surgical procedure) increased postoperative complications.

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Notification of establishment of a new Privacy Act System of Records 09-25-0148. CCA, common carotid arteryECA, external carotid arteryICA, internal carotid arteryPTA, percutaneous transluminal angioplasty. Maternal pre-eclampsia is associated with poor prognosis in extremely premature infants. Economic evaluation under the perspective of the Brazilian Public Health System. The different testing conditions of the 6MWT (track/turns) results in significant differences that need standardization for use in future trials. We recommend that medical terms should be replaced with more common and nontechnical words in consent forms. A method has been established for simultaneous determination of sodium sulfate, sodium carbonate, and sodium tripolyphosphate in detergent washing powder samples based on attenuated total reflectance Fourier transform IR spectrometry in the mid-IR spectral region (800-1550 cm(-1)). The amino acid composition and the N-terminal sequence of the first 15 amino acids of the enzyme exhibited close homology with the other iron-containing SODs. The few epidemiological studies on UFP and (cause-specific) mortality so far have reported inconsistent results. Finally, it was also observed that expression of F505 p56lck greatly increased TCR-induced tyrosine phosphorylation of phospholipase C-gamma 1, raising the possibility that phospholipase C-gamma 1 may be a substrate for p56lck in T lymphocytes.

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Elderly persons with lower incomes consume less alcohol than those with higher incomes. Innovation in gynecologic surgery is constantly evolving toward making procedures less invasive. The study is based on a full numerical simulation of the holographic process, which provides useful rules. The main endpoint was the ability of FDG PET-CT to detect secondary lesions and the possible resulting changes in disease staging and management compared with pre-FDG PET-CT data including clinical examination, sentinel lymph node biopsy (SLNB), and diagnostic CT. This work introduces a method for real-time evaluation of images without any staining, phase-contrast or dilution techniques, differently from studies present in the literature. To determine the incidence of Postoperative nausea and vomiting (PONV) in a high risk surgical group following studies in other predominately black populations that showed a lower rate of postoperative nausea and vomiting than that reported from Caucasian and Oriental populations. Darkening of the root or the presence of 2 or more radiographic signs were positive predictors of a postoperative IDN deficit. Arthroscopic fixation using the TightRope device for acute AC joint dislocation achieves satisfactory outcome. Complete return of function has been obtained following neurosurgical repair of a trochlear nerve inadvertently divided during the clipping of a basilar tip aneurysm.

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We investigated the degree of perceived stress in PWE and its predictors. The decreased inhibitory responses of striatal neurons to SKF 38393 returned to normal levels after a one-day withdrawal. Right atrial pressure (v-wave) was higher, and the cardiac index (CI) was lower in the nonsurviving group. This paper describes a documentation project to create, collect and preserve previously unavailable sources on informatics in Sweden (including health care as one of 16 subgroups), and making them available on the Web. Evaluation of hearing aid rehabilitation using the Freiburg Monosyllabic Test.

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Codon optimization of the major antigen encoding genes of diverse strains of influenza a virus. With the impending large turnover in family medicine leadership, there will be an opportunity to recruit chair replacements with similar viewpoints toward research, thus improving the outlook for research in academic family medicine. However, the ability of an instrument to perform a test does not guarantee that those results are accurate. Cell-mediated immunity in severely head-injured patients: the role of suppressor lymphocytes and serum factors. While creating difficulties and underscoring the inherent weaknesses of this model of MS in straightforward translation from EAE to the human disease, this variability also creates an opportunity to explore multiple facets of the immune and neural mechanisms of immune-mediated neuroinflammation and demyelination as well as intrinsic protective mechanisms. One of the optimal treatment methods for dystonia is chemodenervation using botulinum toxin type A (BTX-A), alcohol injection, etc., but its success depends on how precisely the dystonic muscle is selected. This paper examines the relationship between alcohol control measures, alcohol consumption and selected indicators of alcohol related harm in fifteen countries of Europe and in Israel. Seat belt lesions of the female breast are seldom referred in the literature. FD-OCT and IVUS for detection of incomplete stent apposition in heavily calcified vessels: novel insights. In this cross-sectional study, a questionnaire was distributed to all patients who attended a patient education conference.

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