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Bonine (Meclizine)
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Bonine

Bonine is used to treat or prevent nausea, vomiting, and dizziness caused by motion sickness. Bonine is also used to treat symptoms of vertigo (dizziness or spinning sensation) caused by disease that affects your inner ear.

Other names for this medication:
Bonine, Comfurt, Diligan, Meclizine, Pregnigoxin, Progenidoxin, Pyrinate

Similar Products:
Nuvigil, Anafranil, Medrol, Benemid, Cytoxan

Also known as: Meclizine

Description

Meclizine is used to prevent and control nausea, vomiting, and dizziness caused by motion sickness. It is also used for vertigo (dizziness or lightheadedness) caused by ear problems.

Meclizine is an antihistamine. It works to block the signals to the brain that cause nausea, vomiting, and dizziness.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain meclizine. It may not be specific to Bonine/25. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

Chew or crush the chewable tablet completely before swallowing. Do not swallow it whole.

Swallow the non-chewable tablet whole. Do not crush, chew, or break it.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets): For nausea, vomiting, and dizziness caused by motion sickness: Adults—At first, 25 to 50 milligrams (mg) taken 1 hour before travel. You may take another dose once every 24 hours while traveling. Children 12 years of age and older—Use and dose must be determined by your doctor. Children younger than 12 years of age—Use is not recommended. For vertigo: Adults—25 to 100 milligrams (mg) per day, taken in divided doses. Children—Use and dose must be determined by your doctor.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Meclizine dosage information

Side effects

The most common side effects associated with Bonine are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Avoid driving or hazardous activity until you know how meclizine will affect you. Your reactions could be impaired.

Drinking alcohol can increase certain side effects of meclizine.

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A case of double inlet right ventricle in which both atrioventricular valves opened completely into the right ventricle is described. The fusion of a pyridine ring to the system to give a pentacyclic compound resulted in a molecule sufficiently planar to allow for a weak direct mutagenic effect against TA1537. Discovery of hidden allosteric sites as novel targets for allosteric drug design. Host-pathogen interactions within lesions are a dynamic process, driven by subtle and local differences in signaling pathways, resulting in diverging trajectories of lesions within a single host. An external validation of 76 patients in 2011 was prospectively studied at the same institution. The skin cholinergic signalling system is modulated in atopic dermatitis (AD). The Core Sets for schizophrenia have potential use in supporting rehabilitation practice such as for planning mental health services and other interventions or defining rehabilitation goals, and documenting patient care.

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To establish HPLC fingerprint of Gentiana macrophylla, which was expected to be standards of quality control and identification of the Chinese crude drug. Our findings indicate an involvement of aggressor lymphocytes against keratinocytes as the chief pathogenetic mechanism of the disease, even in its chronic form, although the participation of humoral factors in some phases of the disorder cannot be excluded. Comparison of effects of resistance and multicomponent training on falls prevention in institutionalized elderly women. These antisense oligos were injected into the lateral ventricles of mouse brain using a Hamilton micro-syringe, with saline and oligos of scramble sequences as controls. Participants answered an online questionnaire about depressive symptoms and related consequences in the workplace. We selected the melanocortin-4 receptor (MC4R) as a target because its blockade could provide a treatment for anorexia and cachexia. This article offers tools for this preparation, administering and control of local anaesthesia in children and mentally disabled persons.

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A natural product library comprising 3000 microbial culture extracts was screened via an adenylate kinase (AK)-based cell lysis assay to detect antifungal metabolites targeting the cell envelope of plant-pathogenic fungi. Global causes of vision loss in 2015: are we on track to achieve the Vision 2020 target?. Light chain (AL) amyloidosis frequently involves the kidney, causing significant morbidity and mortality. Active and structured education modalities might be more likely to result in competency in community medicine. Abstracts of the Singapore Urological Association Meeting: UROFAIR 2015, 12-14 March, 2015, Singapore. Effects of sympathetic stimulation on discharges of carotid sinus baroreceptors.

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Examining the association of MMP-1 gene -1607 (2G/1G) and -519 (A/G) polymorphisms with the risk of osteomyelitis: A case-control study. To determine if baseline 3-dimensional (3-D) biomechanical gait patterns differed between those patients with moderate knee osteoarthritis (OA) who progressed to total knee arthroplasty (TKA) and those that did not, and whether these differences had predictive value. A structured questionnaire was completed by 523 clinical nurses to analyze the relationships between concepts of CWHM-organizational culture, social support, employee health, organizational health, and quality of work life. Perforations of both esophagus and aorta after swallowing foreign bodies have been described, with aorto-esophageal fistulas at the level of the descending aorta or aortic arch. The authors report on the first part of an ongoing controlled trial (52 cases) on the evaluation of the effectiveness of Li2CO3 treatment of drug-induced leukopenia in patients with solid tumors. Factors influencing the outcome from ultrasonography-guided fine-needle aspiration of benign thyroid cysts and partially cystic thyroid nodules: A multicenter study. To investigate quantitative 2D ultrashort echo time magnetization transfer (UTE-MT) imaging in ex vivo bovine cortical bone and in vivo human tibial cortical bone.

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Patients with ST-segment elevation myocardial infarction (STEMI) caused by plaque rupture are at high risk for no reflow. Interleukin (IL)-17, expressed by T helper (Th)17 cells, is involved in recruitment of inflammatory cells into AD and CD skin. A comprehensive literature search was conducted in CINAHL Plus, Abstracts in Social Gerontology, AgeLine, Social Work Abstracts, PubMed, PsychINFO, and Social Science Citation Index databases to identify relevant articles that presented multivariate analysis results. To investigate the role of selected serum microRNA (miRNA) levels as potential noninvasive biomarkers for differentiating S0-S2 (early fibrosis) from S3-S4 (late fibrosis) in patients with a chronic hepatitis B virus (HBV) infection. In addition, it is shown that near-edge multiple scattering analysis can give important three-dimensional structural information, which usually cannot be accessed using EXAFS analysis. Polarization attraction of 10-Gb/s NRZ-BPSK signal in a highly nonlinear fiber. THE TSC SCALES : SOCIAL UNDESIRABILITY OR PERSONAL MALADJUSTMENT?. On the synthesis of N-carboxymethylcysteine and its condensation with pyruvic acid. Pathogenesis of paroxysmal hypertension developing during and after coronary bypass surgery: a study of hemodynamic and humoral factors.

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Counseling to discourage douching may reduce STI risk in adolescents. A boy with the classical clinical manifestations of acquired lipoatrophic diabetes has been studied for 5 years from the onset of diabetes at age 13. Molecular evolution of cytochrome bd oxidases across proteobacterial genomes. These findings suggest that patients with anemia should be monitored closely during all types of anticoagulant treatment. These results suggest a reassuring safety profile for Pandemrix with regard to the risk of rejection in SOT recipients in England and contribute to inform the benefit-risk of AS03-adjuvanted pandemic influenza vaccines in transplanted patients in the event of future pandemics. Carnitine and carnitine palmitoyltransferase are active in the transfer of fatty acids into the mitochondria for oxidation.

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Sources of cancer-related information are rapidly increasing, but little is known about whether the health information available to cancer survivors meets their needs. In this work, we aim to engineer dermal tissue micromodules obtained by culturing human dermal fibroblasts into porous gelatine microscaffold. Finally, the cyst wall was imbricated and the bony cavity was filled with pedicled muscle flaps. In this study, we aimed to investigate whether partial bladder outlet obstruction (PBOO) induces changes in the contraction and relaxation response of corpus cavernosum smooth muscle (CCSM) of the penis in the rabbit model. Relapses that occurred when deoxyspergualin was discontinued were treated with repeated courses of deoxyspergualin or with pulsed intravenous cyclophosphamide. In many infectious diseases, PCR results are difficult to interpret as their predictive positive and negative values are not always known. We present examples of the application of FPs and biosensors to visualize mechanotransduction events with high spatiotemporal resolutions in live cells.

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Two-dimensional immune profiles improve antigen microarray-based characterization of humoral immunity. A Case of a Patient with Distal Bile Duct Carcinoma Who Underwent Surgical Resection Three Times for Pulmonary Metastases. Oral hygiene scores averaged 1.7 (of 3) for the PI-LTC, 1.5 (of 4) for the GI-LTC, and 2.2 (of 4) for the DPI. This paper describes theoretical and experimental investigations of an optical time domain reflectometry (OTDR) that conducts measurements in the 2-LP mode region of the fiber under test. The conformation of polyelectrolyte aggregates as a function of the backbone rigidity is investigated by coarse-grained molecular dynamics simulation. Frontotemporal lobar degeneration (FTLD) has different clinical phenotypes and is associated with several pathologic findings, most commonly dementia lacking distinctive histology or Pick disease. Improvement of oleuropein extractability by optimising steam blanching process as pre-treatment of olive leaf extraction via response surface methodology. Professionals in psychiatry often encounter patients who injure themselves. The pathologic examination confirmed metastatic clear cell carcinoma. While past studies have suggested limits to reverse evolution, there have been few attempts to properly dissect its mechanistic constraints.

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