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Capget (Capecitabine)
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Capget

Capget is an anticancer medication. Inside the body, this medicine gets converted into 5-fluorouracil (chemical). This chemical hampers the synthesis of genetic materials (RNA and DNA) in the cancer cells, thereby interferes with their growth.

Other names for this medication:
Capecitabine, Capegard, Capehope, Capget, Capiibine, Capres, Capscare, Captabin, Capxcel, Distamine, Naprocap, Xabine, Xelocel

Similar Products:
Moduretic, Xenical, Flonase, Uroxatral, Sovaldi, Eldepryl, Lexapro

Also known as: Capecitabine

Description

{name} (capecitabine) is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body.

{name} is used alone or in combination chemotherapy to treat colon cancer, breast cancer, or colorectal cancer.

{name} is sometimes used when cancer has spread to other parts of the body (metastatic).

Dosage

Usual Adult Dose of Capget for Colorectal Cancer:

MONOTHERAPY: For first line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles ADJUVANT TREATMENT IN PATIENTS WITH DUKES' C COLON CANCER: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles for a total of 8 cycles (24 weeks) Comments: -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Colorectal Cancer: -As monotherapy for adjuvant treatment in patients with Dukes' C colon cancer who have undergone complete resection of the primary tumor when treatment with fluoropyrimidine therapy alone is preferred; this drug was non-inferior to 5-fluorouracil and leucovorin (5-FU/LV) for disease-free survival (DFS); physicians should consider results of combination chemotherapy trials, which have shown improvement in DFS and OS, when prescribing this drug as a single-agent in the adjuvant treatment of Dukes' C colon cancer -As first-line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred; combination chemotherapy has shown a survival benefit compared to 5-FU/LV alone; survival benefit over 5-FU/LV has not been demonstrated with this drug as monotherapy; use of this drug instead of 5-FU/LV in combinations has not been adequately studied to assure safety or preservation of the survival advantage

Usual Adult Dose of Capget for Breast Cancer:

MONOTHERAPY: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period combined with docetaxel 75 mg/m2 as a 1 hour IV infusion, every 3 weeks IN COMBINATION WITH DOCETAXEL: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles Comments: -The manufacturer prescribing information for docetaxel should be consulted for premedication advice. -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Breast Cancer: -In combination with docetaxel for the treatment of patients with metastatic breast cancer after failure of prior anthracycline-containing chemotherapy -As monotherapy for the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen or resistant to paclitaxel and for whom further anthracycline therapy is not indicated (e.g., patients who have received cumulative doses of 400 mg/m2 of doxorubicin or doxorubicin equivalents); resistance is defined as progressive disease while on treatment, with or without an initial response, or relapse within 6 months of completing treatment with an anthracycline-containing adjuvant regimen

Detailed Capget dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep container tightly closed. Do not store in the bathroom, near the kitchen sink, or in other damp places. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Capget are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

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Hydrogels That Allow and Facilitate Bone Repair, Remodeling, and Regeneration. Senescence-associated heterochromatin is now shown to limit DDR, thus reducing apoptosis and promoting survival of senescent cells. Whole-lung gene expression analyses were conducted to identify genomic responses to allergen challenge. Using phenotypic data available for mouse, a possible association between the ovarian transcriptome, reproductive records and spontaneous ovarian tumor rates was investigated in four mouse inbred strains. Early prophylaxis may be safe and should be the goal for each patient in the context of appropriate risk stratification. Abstracts of the 3rd Annual Scientific Meeting Indonesian Heart Rhythm Society, October 23 - 24, 2015. Small Molecule-Assisted Exfoliation of Layered Zirconium Phosphate Nanoplatelets by Ionic Liquids.

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Tooth whitening is a widely utilized esthetic treatment in dentistry. To contribute to a better understanding of the underlying mechanisms, in the present study, we investigated the properties of a poly(ethylene oxide-b-4-vinylpyridine) diblock copolymer as vector for nucleic acid transfer, with the particular aim of shedding some light on a possible mechanism explaining the internalization of DNA by the transfected cells. Familial primary localized cutaneous amyloidosis in a Japanese family. This study was to evaluate the role of quantitative perfusion analysis of 3-dimensional (3D) contrast-enhanced ultrasound (CEUS) in detecting microvascular invasion (MVI) of liver tumor in vivo. The current study aims to assess the role of ultrasound (US) parameters in explaining the variance of hydronephrosis grades in reno-urinary anomalies, as well as their performance in quantifying the incidence of patients with uropathies. The location-independence for A/C uEPSP amplitudes may be relevant in the recruitment of CA3 pyramidal cells by other CA3 pyramidal cells. Mammalian cortical structures are endowed with the capacity for plasticity, which emerges from a combination of the dynamics of circuit connectivity and function, and the intrinsic function of the neurons within the circuit. Serotonin (5-HT) and thromboxane A2, which are released from aggregating platelets, mediate platelet-induced vasoconstriction, which itself significantly contributes to coronary artery constriction in vivo.

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Preoperative smoking was only associated with an increased risk for breast cancer events and distant metastasis in AI-treated patients. Fatal skin and soft tissue infection of multidrug resistant Acinetobacter baumannii: A case report. Only studies evaluating the use of ultrasound as an adjunct to mammography in the specified populations were included. Structures, biosynthesis, and functions of gangliosides--an overview. In this study, for the first time, we transplanted microcarrier-expanded hESC-derived NPCs into the striatum of adult NOD-SCID IL2Rgc null mice, either as single cells or as cell aggregates. Effective regulation of the CL, follicles, and hormonal environment during each part of the protocol is critical for optimizing these programs. Moreover, cholesterol synthetic capacity is impaired in cultured skin fibroblasts obtained from patients with peroxisomal deficiency diseases. The aim of the present study was to explore the opinions of general practitioners (GP) and practice nurses on the acceptability and feasibility of a new form of partner notification developed in the specialist setting known as Accelerated Partner Therapy (APT), for sex partners of those diagnosed with a bacterial STI in general practice. At that time, a long-acting analog of luteinizing hormone-releasing hormone (LHRHa), leuprolide acetate, was prescribed. Ligand modification, receptor mutagenesis and computational modelling approaches were used to identify the binding mode of FC131 in CXCR4, which was in agreement with binding modes suggested from previous SAR studies.

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That is, spo0E11 and abrB mutations caused a synthetic (synergistic) sporulation phenotype. Ten patients in the first group and 5 patients in the second group were resistant to therapy. Purification and characterization of an extracellular haloalkaline serine protease from the moderately halophilic bacterium, Bacillus iranensis (X5B). This review describes the theoretical basis, application, and analysis of DT imaging as it pertains to neurosurgery. There has been very little information published that addresses the use of filtered light for evaluating TLC plates.

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How implementation of systems biology into clinical trials accelerates understanding of diseases. Synthesized radio communications: looking back, looking forward. On the basis of the investigation of the ancient sources the significant input of the mentioned physicians into the development of the traditional Chinese medicine, dietetics and diet therapy included is testified. The quantity of FPOM (g) increased with forest cover, and the relative amount of FPOM (percentage of total particulate material) in the traps increased with surface area of wetland in the catchments. The hippocampus and the anterior insula may serve as hubs facilitating the switch between engagement of a defensive immediate fear network and a resting network. We also present supporting evidence for the utilization of stem cell technology in the treatment of amyotrophic lateral sclerosis and spinal muscular atrophy, and describe key issues that must be considered for the transition of stem cell therapies for motor neuron diseases from bench to bedside. We found that wild-type Ndi1 formed a stable charge transfer (CT) complex (around 740 nm) with NADH, but not with NADPH, under anaerobic conditions. Transgenic Populus (poplar) trees expressing either a miRNA-resistant POPCORONA or a synthetic miRNA targeting POPCORONA were used to infer function of POPCORONA during secondary growth.

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Larval green and white sturgeon swimming performance in relation to water-diversion flows. It also reviews the epidemiological parameters that help to understand the impact of its implementation. We demonstrate, for the first time, marked exercise impairment and cardiac compression in patients with a large HH and normal respiratory function. Here, we present the main features of cnidarian models and their advantages for research, and summarize key recent findings using these models that have informed our understanding of the evolution of the developmental processes underlying metazoan body plan formation. Selected genes were further examined during retinal development and in adult retinas by in situ hybridization and immunohistochemistry and in a transgenic fluorescent reporter line.

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This will make it possible for marginalized women to utilize cancer screening tests and in turn promote their health. Adjustment to fatigue is likely to be influenced by coping behaviours that are guided by the representations of the symptom. The Gouldian finch represents a relatively well-studied endangered species, which has a seasonal and site-specific pattern of condition index variation that differs from the closely related non-declining long-tailed finch. Although SCV E18 was sensitive to oxygen as it entered the stationary phase, it was significantly more tolerant to H2O2 than the wild type, which may result from a shift in metabolism, however, further investigation is needed to resolve this. In an in vivo xenograft model, MIF knockdown reduced the tumor growth rate. A model to calculate bone resorption driven by fluid flow at the bone-soft tissue interface is developed and used as a basis for computer calculations, which are compared to experiments where bone is subjected to fluid flow in a rat model. Laser frequency modulation noise measurement by recirculating delayed self-heterodyne method.

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The proximal promoter was analyzed for binding of nuclear proteins from small intestine and liver. Potential of Agarose/Silk Fibroin Blended Hydrogel for in Vitro Cartilage Tissue Engineering. Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers. Progression of CAC is the usual evolution pattern of CAC in renal transplant recipients. This might result in a depression of the hyperreactive immune system including the autoimmunity developed against cartilage. Among suicide attempts in the past year, lethality significantly increased as the length of time since the last alcoholic drink increased. CE within 48 h of overt bleeding has the greatest potential for lesion detection. We describe childhood growth patterns in a series of well-characterized patients with congenital hypogonadotropic hypogonadism (CHH) with special emphasis on genotype-phenotype correlation. Randomized controlled trials with restricting diets can help to elucidate the results.

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We discuss the possible functional meaning of commissural and cross-striolar inhibition. The quantity of soot particles in the emissions is determined by the balance between the rate of formation and subsequent oxidation. However, the relationship between serum uric acid and prognosis in diabetic peritoneal dialysis (PD) patients is unclear. The UHR subjects had a similar pattern of neuropsychological dysfunction but less severe than that of FE patients. Heparin and related members of the glycosaminoglycan (GAG) family are highly polyanionic linear saccharides that play important roles in a variety of physiological processes ranging from blood coagulation to embryo- and oncogenesis, tissue regeneration, and immune response regulation. Herein, we report the identification of an influx transporter of Si in two Cucurbita moschata (pumpkin) cultivars greatly differing in Si accumulation, which are used for the rootstocks of bloom and bloomless Cucumis sativus (cucumber), respectively. We discuss the implications of our results for determining rational stop criteria and their influence on the design of efficient and reliable proteomics studies.

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To develop a Somatic Symptoms Scale based on the criteria of standard symptoms, and to examine its psychometric properties through exploratory factor analysis. A study of the biosynthetic regulation of these enzymes by two different nitrogen sources, glutamine and asparagine, was carried out. In this article, we discuss the methods for observing single RNAs in living cells, highlighting the advantages and limitations of each method. Mortality after shoulder arthroplasty: 30-day, 90-day, and 1-year mortality after shoulder replacement--5853 primary operations reported to the Danish Shoulder Arthroplasty Registry. Nearly half of the patients have had vertebral anomalies predominating in the cervical spine, and of these, most were vertebral fusions. Control rabbits received a balanced salt solution instead of methotrexate.

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Secondary outcomes were repeated ED visits and change in AQLQ scores at 4, 12, and 16 weeks and 1 year. Twenty metabolic and haemodynamic variables were recorded throughout exhaustion-limited cycling ergometry. Severe periodontal diseases were more prevalent in patients with more severe CKD than in those with less severe CKD. These findings highlight the challenges of correctly managing severe malaria in resource limited settings. Neuroinflammation appears as a prominent feature of the mesiotemporal lobe epilepsy syndrome (MTLE) that is observed in human patients and animal models. There is compelling evidence suggesting that infections are associated with reduced allograft and patient survival. Endurance exercise training enhances cutaneous microvascular reactivity in post-menopausal women. Exhaustive Conformational Sampling of Complex Fused Ring Macrocycles Using Inverse Kinematics. This study may have implications for understanding relevant biological motifs and for use of perversions as energy storers in the design of micromuscles and soft robotics.

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In a retrospective study, we assessed intraarterial growth in myopericytomas, co-existence with arterial intimal thickening (IT) and the relationship between the two. miRNA-21 (miR-21) appears to be important in the tumourigenesis of almost all types of human cancer. Genetic, cytogenetic, and molecular analyses of mutations induced by melphalan demonstrate high frequencies of heritable deletions and other rearrangements from exposure of postspermatogonial stages of the mouse. To investigate the relationship between attentional bias to cocaine-related stimuli, impulsivity, and inhibitory control in cocaine dependence. Demographics and clinical correlates were collected, including body mass index, estimated glomerular filtration rate (eGFR) and other measures. Enhancement and reduction by methylated oxypurines of the frequencies of chromatid aberrations induced by camptothecin in root-tip cells of Vicia faba. Neurological function and histomorphological examinations showed that compared with the rats receiving local saline treatment, those receiving flagyl tablet dose local glioblastoma cyst fluid treatment had better sciatic nerve function, fewer scars, greater axon area, counts and diameter as well as fiber diameter. It has been suggested that the plasma membrane directly inhibits actin assembly by serving as a physical barrier that opposes protrusion. Validity of leptin receptor-deficiency (db/db) type 2 diabetes mellitus mice as a model of secondary osteoporosis.

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The glycosaminoglycan heparan sulfate is an important receptor for rosetting. Bayesian hybrid dose-finding design in phase I oncology clinical trials. An all-atom description is compared with a united-atom approach. These ex vivo results would provide a biological basis to data available from studies showing a clinical benefit with the use of G-CSF as a priming agent in patients with a chemosensitive AML and would support implementation of further studies exploring new strategies of chemotherapy priming in AML. Elderly patients should be offered peritoneal dialysis (PD) as well as hemodialysis (HD), which can be performed either at home (PD) or at a dialysis center (HD or PD). The aim of this study was to purify and characterize an antioxidative peptide from SPI and determine its antioxidative mechanism. Restricting anorexia nervosa patients, who had lost weight by consistently reducing their food intake, reported significantly greater self-control, inhibition of emotionality, and conscientiousness than controls or bulimia nervosa patients, before and after the data were corrected for depressive and eating pathology. In the course of evaluating methods for growing corneal endothelial cells, we have noted a case where remarkable growth was achieved using a serial explant culture technique. The purpose of this study was to determine the rate and time course of functional changes 3 months after hospital discharge for AE-COPD compared with baseline levels 2 weeks before admission, and to identify predictors of functional decline. Less than one hundred cases have been reported in the English literature to date.

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Favorable Short-term Outcome in Deceased Kidney Donor Transplantation. An increased ability to generate hydrogen peroxide in certain polymorphonuclear leukocytes in neonates. We conclude from our results that the two halves of P-glycoprotein approach each other to form a single binding site for these drugs. First, we establish the effect of the anodisation period as a means of tuning the position and width of the transmission bands of NAA across the UV-visible-NIR spectrum. On the basis of digital subtractive angiography (DSA) arterial vascularization of lower extremities of six children with congenital hypoplasia of the leg has been studied. Immunocytochemical localization of vasoactive intestinal peptide and substance P in the colon from normal subjects and patients with inflammatory bowel disease. Involvement of Chk1-Cdc25A-cyclin A/CDK2 pathway in simvastatin induced S-phase cell cycle arrest and apoptosis in multiple myeloma cells. These insights into the genome biology of a polyploid crop provide a springboard for faster gene isolation, rapid genetic marker development, and precise breeding to meet the needs of increasing food demand worldwide. Desferrioxamine B (DFO, Desferal), an iron chelator, was earlier shown to be active against Plasmodium falciparum in vitro and in vivo. Inositol activity in oligoasthenoteratospermia--an in vitro study.

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In patients who undergo resection of colorectal liver metastases (CLM) with curative intent, KRAS mutation is associated increased risk of recurrence, worse survival, and increased recurrence outside of the liver, particularly in the lung, but also in the brain 20 mg prevacid and bone. However, whether ATRA can improve BSE remains unclear in suicide gene therapy for breast cancer. Within the bilateral distributed network engaged for processing environmental sounds across all conditions, we report here a highly significant dissociation within the left hemisphere between the processing of visual perceptual and encyclopedic attributes of objects. wt) of 200 kDa (P200) and its synthesis shows a 24 hr periodicity. We evaluated cell viability using MTT assay, the expression of Bax and Bcl-2, as markers for apoptosis and the expression of cyclin D1 as a marker for cell proliferation 24h after each irradiation.

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Clinical engineering services at the VA Medical Center, Los Angeles. This meeting report summarizes the history of the HCIR symposium and emphasizes its relevance to the data science community. Semantic Richness Effects in Spoken Word Recognition: A albenza tablet cost Lexical Decision and Semantic Categorization Megastudy. Because there is no contribution to the heavy peptide signal from endogenous analyte, it is possible to measure the equivalent of a blank sample and determine LOQ. It also highlights those compounds that are currently undergoing preclinical or clinical evaluation. For this purpose, polymerization of an iodine- and bromine-functionalized precursor was studied on Au(111) by scanning tunneling microscopy under ultrahigh vacuum conditions.

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In general it can be distinguished between two immobilization methods: (1) entrapment into polymers and (2) natural adsorption onto porous and inert support materials. Epithelial-mesenchymal transition (EMT) plays a fundamental role in tumor progression and metastasis formation by invasion, resistance to cell death and senescence, resistance to chemotherapy and immunotherapy, immune surveillance, immunosuppression and inflammation, confers stem cell properties. Our results suggest that attentiveness towards conspecifics, whether interacting or not, activates pathways linked to neuronal plasticity and memory formation. New techniques of separation, such as supercritical fluid chromatography and capillary zone electrophoresis, have not yet been applied for the determination of therapeutic concentrations of antidepressants. Further, we compared our method in terms of correctly aligned pairs ratio and columns correctly aligned ratio with respect to reference alignments.

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Our findings indicate that time distortions are strongly linked to the motor system, and they may be unavoidable consequences of the mechanisms subserving sensory-motor integration. A second mode offered community support via weekly face-to-face support group meetings in which physical activities were offered. Inhibitory effect of 2-hydroxypropyl-beta-cyclodextrin on crystal-growth of nifedipine during storage: superior dissolution and oral bioavailability compared with polyvinylpyrrolidone K-30. In contrast, the percentage of brain tissue per volume, a control measure, was correlated between the three anterior regions. Flow characteristics have been obtained in 16 consecutive transverse rectus abdominis myocutaneous flaps using the laser Doppler, where 2 were shown to have been in jeopardy for major flap loss. Effect of hypoxia on expression of iNOS mRNA in cultured rat astrocytes. An Official Critical Care Societies Collaborative Statement: Burnout Syndrome in Critical Care Healthcare Professionals: A Call for Action.

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Improvement of the ultra-trace voltammetric determination of Rh in environmental samples using signal transformation. Photoacoustic imaging is an emerging technique for anatomical and functional sub-surface imaging but previous studies have predominantly focused on time-domain analysis. Here, we coupled bioinformatics with lipid analyses to investigate the scope of bacterial sterol production. This information can help clinicians who are developing PC services in a MME country. Zinc contents of pancreatic islets in animals of various species after administration of diabetogenic agent, dithizone. It is postulated that the site of action of phospholipase A2 may be partly protected in the hydrophobic region of the tightly packed surfactant film. To risperdal consta reviews evaluate the clinical effectiveness of transurethral seminal vesiculoscopy (TUSV) combined with finasteride in the treatment of recurrent hemospermia.

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