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Captabin (Capecitabine)
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Captabin

Captabin is used alone or in combination chemotherapy to treat colon cancer, breast cancer, or colorectal cancer. Captabin is sometimes used when cancer has spread to other parts of the body (metastatic).

Other names for this medication:
Capecitabine, Capegard, Capehope, Capget, Capiibine, Capres, Capscare, Captabin, Capxcel, Distamine, Naprocap, Xabine, Xelocel

Similar Products:
Ambien, Actos, Imodium, Azulfidine, Cymbalta, Crestor, Fasigyn, Artane, Nuvigil, Seroquel

Also known as: Capecitabine

Description

{name} (capecitabine) is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body.

{name} is used alone or in combination chemotherapy to treat colon cancer, breast cancer, or colorectal cancer.

{name} is sometimes used when cancer has spread to other parts of the body (metastatic).

Dosage

Usual Adult Dose of Captabin for Colorectal Cancer:

MONOTHERAPY: For first line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles ADJUVANT TREATMENT IN PATIENTS WITH DUKES' C COLON CANCER: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles for a total of 8 cycles (24 weeks) Comments: -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Colorectal Cancer: -As monotherapy for adjuvant treatment in patients with Dukes' C colon cancer who have undergone complete resection of the primary tumor when treatment with fluoropyrimidine therapy alone is preferred; this drug was non-inferior to 5-fluorouracil and leucovorin (5-FU/LV) for disease-free survival (DFS); physicians should consider results of combination chemotherapy trials, which have shown improvement in DFS and OS, when prescribing this drug as a single-agent in the adjuvant treatment of Dukes' C colon cancer -As first-line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred; combination chemotherapy has shown a survival benefit compared to 5-FU/LV alone; survival benefit over 5-FU/LV has not been demonstrated with this drug as monotherapy; use of this drug instead of 5-FU/LV in combinations has not been adequately studied to assure safety or preservation of the survival advantage

Usual Adult Dose of Captabin for Breast Cancer:

MONOTHERAPY: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period combined with docetaxel 75 mg/m2 as a 1 hour IV infusion, every 3 weeks IN COMBINATION WITH DOCETAXEL: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles Comments: -The manufacturer prescribing information for docetaxel should be consulted for premedication advice. -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Breast Cancer: -In combination with docetaxel for the treatment of patients with metastatic breast cancer after failure of prior anthracycline-containing chemotherapy -As monotherapy for the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen or resistant to paclitaxel and for whom further anthracycline therapy is not indicated (e.g., patients who have received cumulative doses of 400 mg/m2 of doxorubicin or doxorubicin equivalents); resistance is defined as progressive disease while on treatment, with or without an initial response, or relapse within 6 months of completing treatment with an anthracycline-containing adjuvant regimen

Detailed Captabin dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep container tightly closed. Do not store in the bathroom, near the kitchen sink, or in other damp places. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Captabin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

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This study aims to determine the prevalence and important risk factors related to ophthalmoplegia among diabetic patients. In this study, we investigated the capability of a high-speed form of RCM, termed spectrally encoded confocal microscopy (SECM), to count intraepithelial esophageal eosinophils and characterize other microscopic findings of EoE. The abdominal ultrasonography detected a solid intestinal tumor. Though the parasympathetic tone was dominant in female (higher RMSSD, nHF and lower nLF vs. Global warming may exacerbate inorganic nutrient limitation, including phosphorus (P), in the surface waters of tropical oceans that are home to extensive blooms of the marine diazotrophic cyanobacterium, Trichodesmium. As such, abnormalities in the structure or expression of the IAPP gene might contribute to the inheritance of this condition. The averted mosquito nuisance costs to households are estimated on the basis of a contingent valuation study. This paper provides a brief overview of the current research activities which focused on the bio-application of gold magnetic nanocomposite particles. Telephone communication may require a large time commitment from pharmacists and prevent them from performing activities which are more easily documentable, such as compounding intravenous admixtures. Like mPTL, mPLRP2 exhibited strong activity against various triglycerides.

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p40 is more specific than p63 for the distinction of atypical fibroxanthoma from other cutaneous spindle cell malignancies. This article reviews the current understanding of the epidemiology of resistant hypertension. It is suggested that the astrocyte activation is associated with immune changes in schizophrenia. Atherosclerosis-induced ischemia caused alteration in production and release of endothelial factors. The combination of atenolol and ICI 118,551 attenuated the responses to each stimulation more than atenolol alone. The Cinnamomum group appears to have originated in the widespread boreotropical paleoflora of Laurasia during the early Eocene (ca. Logarithms of one plus the count of each variable were taken from the raw data and these were analysed using percentile distribution and the median, the t-test, Mann-Whitney U test and the Wilcoxon signed rank test. The Ezh2 polycomb group protein drives an aggressive phenotype in melanoma cancer stem cells and is a target of diet derived sulforaphane. Comprehensive post-operative assessment of apico-aortic conduit for aortic stenosis with cardiac magnetic resonance imaging. On the other hand, the pig shows similarity in size, shape and physiology to human and has been used as a major mammalian model for many studies concerning xenotransplantation, cardiovascular diseases, blood dynamics, nutrition, general metabolic functions, digestive-related disorders, respiratory diseases, diabetes, kidney and bladder diseases, organ-specific toxicity, dermatology and neurological sequelae.

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Unbiased probabilistic taxonomic classification for DNA barcoding. It is almost certain that as our knowledge of endothelial cell function increases, other roles of this important cell will be discovered. The test was performed with 73 blood culture sets (either spiked or clinical blood cultures) with various enterobacterial species. Cutaneous phaehyphomycosis caused by Exophiala jeanselmei var lecanii-cornii (Benedek and Specht) De Hoog. A report of physical abuse carried the greatest risk of subsequent death. We present a hypothetical model on the pathogenesis and evidences to support this hypothesis. tularensis are believed to be confined to North America, whereas strains of F. The purpose of this study is to determine the normative Doppler values and gender differences in left ventricular (LV) diastolic function in healthy subjects at each decade of life. Prediction of functional capacity during six-minute walk among patients with chronic heart failure. The students and trainees reported changed attitudes and subjective knowledge growth regarding the other professional groups.

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The human hCLCA1 and its murine ortholog mCLCA3 (calcium-activated chloride channel regulators) are exclusively expressed in mucus cells and linked to inflammatory airway diseases with increased mucus production, such as asthma, cystic fibrosis and chronic obstructive pulmonary disease. There is a high prevalence of undiagnosed hypertension and prehypertension in the present sample. Simultaneous determination of orysastrobin and its isomers in rice using HPLC-UV and LC-MS/MS. coli disclosed properties similar to those found for the enzyme extracted from S. We report a different mechanism of repeated excessive implant motility in both eyes of a young woman who developed late nontraumatic elongation of the iris fibers to which an iris-claw pIOL was fixated. In accordance with the earlier findings, the present analysis indicated that schools nationwide were focusing their efforts on a few policies and programs rather than addressing the entire set of recommendations in the SHI. Genomic instantiation of consciousness in neurons through a biophoton field theory. MAb QCR1 recognizes blood vessels, blood cells, and cartilage cells, MAb QB1 recognizes quail blood vessels and blood cells, and MAb QB2 recognizes quail blood vessels, blood cells, and mesenchymal tissues.

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This is the first report to demonstrate that Brachyury might affect the cytoskeletal structure through regulating the expression of an intermediate filament protein, vimentin. Binding of avian myeloblastosis reverse transcriptase to matched and mismatched base pair termini. Labeled cDNA prepared from RNA isolated at different times was hybridized with Southern blots of viral DNA to show which regions of the genome are transcribed at different times. The renin-angiotensin system in 2011: new avenues for translational research. The present work describes a novel and efficient method of synthesis of amphiphilic hyaluronan (HA) by esterification with alkyl fatty acids. Cholera typically occurs in epidemics, spreading rapidly within the community, especially if hygeinic conditions are poor. Although there is considerable variation as to the classes of drugs for which counseling is provided and the types of people who receive it, the components of counseling appear to be constant. Expansive pedicle screw (EPS) and polymethylmethacrylate-augmented pedicle screw (PMMA-PS) were both used to increase screw stability. Low concentration of NGF resulted in IRF-1 intronuclear transporting, and the expression was not affected. Cohort measurements were de-trended by weighted linear regressions based on independent control values.

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The significance of TNF-alpha gene polymorphisms in preterm delivery. Monitoring lidocaine single-crystal dissolution by ultraviolet imaging. Stably inherited killer activity in industrial yeast strains obtained by electrotransformation. The winds and surface currents during November were the driving forces for the transportation and deposition of MPPs from the sea to beaches. We designed a finite element model to analyze skin stresses under a weight-bearing bony prominence while this region of interest slides frictionally over the support surface, as occurs during repositioning.

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The utility of Caco-2 cells in isolation of enteroviruses from environmental and clinical material. The aim of this study is to explore the applications of digital department in otolaryngology concern with the emergent and dangerous of otolaryngology diseases. Even though CTC was reserved for individuals either unsuitable for or unable to complete colonoscopy, we found only small differences in test-related discomfort. NOTCH1 mutations were determined by polymerase chain reaction followed by direct sequencing in 201 previously untreated patients with CLL of B cell origin: 88 CLL patients, sufferers of the Chornobyl NPP accident, and 113 CLL patients of the control group. Targeting markers of angiogenesis in association with confocal laser endomicroscopic examination (immunoendoscopy), as a future challenge, will add functional analysis to the morphological aspect of the neoplastic process. Acute appendicitis remains the most common cause of acute abdominal pain necessitating operative intervention. Speech illusions were elicited in typically developing children in a WN-test paradigm, and point to an affective pathway to AVH mediated by dysregulation in top-down processing of sensory input.

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Data from a clinical trial in onychomycosis further illustrate the method. Modern society demands working conditions in which pregnant women can successfully deliver children and maintain a professional position. Mitral annuloplasty ring detachment in real-time three-dimensional echocardiography. The structural basis for interaction with DNA is unknown, which limits our understanding of PARP-1 regulation and involvement in DNA repair and transcription. Our present data confirm that AFM is a powerful tool to study the structural organization of biological samples, including complex arrays of DNA such as kDNA, and can be useful in revealing new details of structures previously visualized by other means. The provision of inadequate empiric therapy for new and recurrent infections due to ESBL-producing pathogens was common in this study population. Prediction of clinical course of glioblastomas by MRI during radiotherapy. Luminescent Rhenium(I) Pyridyldiaminocarbene Complexes: Photophysics, Anion-Binding, and CO2-Capturing Properties. Here we used a sensitive and objective fast periodic visual stimulation approach while recording scalp electroencephalogram (EEG) to test the effect of size variation on neural responses reflecting individual face discrimination.

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Early diagnosis, antibiotic and surgical treatment can facilitate the treatment and prevent development of complications. Seven patients with sporadic and all three with MEN 1 hyperparathyroidism had allele losses for chromosome 11 in the analysed glands. Results of the present study demonstrate that rotarod performance can be used as a predictive longitudinal, in vivo functional biomarker of MSS concomitant with histological evidence of joint damage to effectively facilitate compound selection during drug discovery. The financial burden of asthma: a nationwide comprehensive survey conducted in the republic of Korea. Some biological features of Candida albicans mutants for genes coding fungal proteins containing the CFEM domain. The potential energy maps, obtained by molecular mechanics calculations, show that acarviosine is flexible and has several important minima. As one of bitter and cold TCMs, the stromatas of Shiraia bambusicola have been used for the treatment of DM and exerted clinical effects to a certain extent. It is well known that the most effective way of priming is by prostaglandins. Margin index is not a reliable tool for predicting residual disease after breast-conserving surgery for DCIS.

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Evaluation of anti-diabetic potential of chromium(III) propionate complex in high-fat diet fed and STZ injected rats. The FMPS method allows the evaluation of morphological characteristics, identifying the melanin pigment and collagen fibers with high intensity simultaneously. The possibility of pulmonary artery rupture was immediately recognized and confirmed with CT angiogram of the chest. We evaluate the performance of CRA, MI without interactions, MI including all interactions, and stratified imputation. Therefore, when adenomyomatous hyperplasia is suspected, a radical surgical procedure according to malignant disease may be necessary for definitive diagnosis. The lateral internal sphincterotomy was done in two parts and at different planes. The in-vitro dissolution, cytotoxicity and in-vivo pharmacokinetic experiments of Cur-NS were also evaluated.

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However, since the vast majority of caged species are triggered by UV light, it is not feasible to orthogonally control two or more spatiotemporal elements of the phenomenon under investigation. miRNA-mRNA integrated analysis reveals roles for miRNAs in primary breast tumors. Poor interobserver reproducibility in diagnosing and grading dysplastic melanocytic nevi is often cited as evidence against the ability of pathologists to recognize such an entity. These results further support efforts to reduce radon concentrations in homes to the lowest possible level. We conducted a prospective cohort study of injured patients recruited at the adult emergency department of the University Hospital of Bordeaux from December 4, 2007, to February 25, 2009. This was interpreted as arising from the reorientation processes of water molecules around the excited state of ANS or probe exchange among different probe locations, occurring on a time scale longer than fluorophore lifetime.

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Fluorescence in situ hybridization analysis of the ALK gene in 2,045 non-small cell lung cancer patients from North-Western Spain (Galicia). Dietary models were produced and compared with a manual Microsoft Excel calculator, a partially automated Excel Solver approach, and the automated DMT that was developed rocaltrol drug classification . Several studies suggested that these anti-PAC1 peptide antibodies were specific for GP IIb-IIIa recognition sites in fibrinogen. Occupational risk prevention in endoscopy units: a pending issue. The role of E2F-1 and downstream target genes in mediating ischemia/reperfusion injury in vivo.

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Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Underlying Mechanisms of can the antibiotic bactrim cause constipation Memory Deficits Induced by Etomidate Anesthesia in Aged Rat Model: Critical Role of Immediate Early Genes. Dimerization of tri(4-bromophenyl)benzene by aryl-aryl coupling from solution on a gold surface. Spectral-domain OCT showed macular thinning with submacular fluid. Speech audiometry, a key component of hearing care, must be customized for this linguistically unique and diverse population. A total of 836 Korean subjects were recruited from an asthma cohort. Histopathologically, the most striking feature consisted of the presence of groups of necrotic adipocytes lacking nuclei and large cytoplasm with pale basophilic hue due to calcium salts deposition. Surgical isolated hepatic perfusion (IHP) has been shown to be effective in patients with various hepatic malignancies, but is complex, associated with high complication rates and not repeatable.

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In our previous studies of nerve conduction conducted by proton hopping, we have considered the axon, soma, synapse and the nodes of Ranvier. Modification of Shape Memory Polymer Foams Using Tungsten, Aluminum Oxide, and Silicon Dioxide Nanoparticles. A chemical genomics screen to discover genes that modulate neural stem cell differentiation. A distal force was applied to long hooks that were crimped between the lateral incisors and the canines. In a mixed population of critically ill patients, the Glasgow Coma Scale score dominates the association between admission SOFA score and 30-day mortality. Root planed, doxycycline-treated surfaces showed characteristics similar to those reported for citric acid conditioning.

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