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Clarinex (Desloratadine)
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Clarinex

Clarinex and its metabolic derivative desloratadine are second generation antihistamines that are used for the treatment of allergic rhinitis, angioedema and chronic urticaria. Clarinex and desloratadine have been linked to rare, isolated instances of clinically apparent acute liver injury.

Other names for this medication:
Alerdain, Alerta, Allerdain, Allerde, Allerede, Allergesic, Antialer, Biomon, Dazit, Delorta, Descare, Desent, Deslor, Desloranid, Desloratadine, Desloriv, Desnova, Dilora, Lorday, Loreta, Nelora, Neoloridin, Nucope, Otrivin, Reditabs, Rodera, Tastylora, Veromon

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Also known as: Desloratadine

Description

Desloratadine and pseudoephedrine is a combination of two medicines used to treat nasal congestion (stuffy nose), sneezing, and runny nose caused by hay fever.

Desloratadine works by preventing the effects of a substance called histamine, which is produced by the body. Histamine can cause itching, sneezing, runny nose, and watery eyes.

The pseudoephedrine causes narrowing of blood vessels. This leads to clearing of nasal congestion, but it may also cause an increase in blood pressure in patients who have high blood pressure.

This medicine is available only with your doctor's prescription.

Do not give any over-the-counter (OTC) cough and cold medicine to a baby or child under 4 years of age. Using these medicines in very young children might cause serious or possibly life-threatening side effects .

Dosage

This section provides information on the proper use of a number of products that contain cough and cold combinations. It may not be specific to Clarinex-D. Please read with care.

To help loosen mucus or phlegm in the lungs, drink a glass of water after each dose of this medicine, unless otherwise directed by your doctor.

Take this medicine only as directed. Do not take more of it and do not take it more often than recommended on the label, unless otherwise directed by your doctor. To do so may increase the chance of side effects.

Do not give any over-the-counter (OTC) cough and cold medicine to a baby or child under 4 years of age. Using these medicines in very young children might cause serious or possibly life-threatening side effects .

For patients taking the extended-release capsule or tablet form of this medicine:

Swallow the capsule or tablet whole. Do not crush, break, or chew before swallowing. If the capsule is too large to swallow, you may mix the contents of the capsule with applesauce, jelly, honey, or syrup and swallow without chewing.

For patients taking the extended-release oral solution or oral suspension form of this medicine:

Do not dilute with fluids or mix with other drugs.

For patients taking a combination medicine containing an antihistamine and/or aspirin or other salicylate:

Take with food or a glass of water or milk to lessen stomach irritation, if necessary.

If a combination medicine containing aspirin has a strong vinegar-like odor, do not use it. This odor means the medicine is breaking down. If you have any questions about this, check with your pharmacist.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Desloratadine/pseudoephedrine dosage information

Side effects

The most common side effects associated with Clarinex are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

If you are breastfeeding, the chance that problems might occur depends on the ingredients of the combination. For the individual ingredients of these combinations, the following apply:

Acetaminophen—Acetaminophen passes into the breast milk. However, it has not been reported to cause problems in nursing babies. Alcohol—Alcohol passes into the breast milk. However, the amount of alcohol in recommended doses of this medicine does not usually cause problems in nursing babies. Antihistamines—Small amounts of antihistamines pass into the breast milk. Antihistamine-containing medicine is not recommended for use while breastfeeding since most antihistamines are especially likely to cause side effects, such as unusual excitement or irritability, in the baby. Also, since antihistamines tend to decrease the secretions of the body, the flow of breast milk may be reduced in some patients. Caffeine—Small amounts of caffeine pass into the breast milk and may build up in the nursing baby. However, the amount of caffeine in recommended doses of this medicine does not usually cause problems in nursing babies. Codeine and other narcotic cough medicines (e.g., dihydrocodeine, hydrocodone, and hydromorphone)—Codeine is changed to morphine in the body. Some people change codeine to morphine more quickly than others. These individuals are called "ultra-rapid metabolizers of codeine". If a nursing mother is an ultra-rapid metabolizer of codeine, it could lead to a morphine overdose in the nursing baby and cause very serious side effects. A nursing mother should talk to her doctor if she has any questions about taking codeine or about how this medicine may affect her baby . Decongestants (e.g., ephedrine, phenylephrine, pseudoephedrine—Phenylephrine has not been reported to cause problems in nursing babies. Ephedrine and pseudoephedrine pass into the breast milk and may cause unwanted effects in nursing babies (especially newborn and premature babies). Iodides (e.g., calcium iodide and iodinated glycerol)—These medicines pass into the breast milk and may cause unwanted effects, such as underactive thyroid, in the baby. Salicylates (e.g., aspirin)—Salicylates pass into the breast milk. Although salicylates have not been reported to cause problems in nursing babies, it is possible that problems may occur if large amounts are taken regularly.

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We allowed the eggs to incubate in the field, then measured offspring phenotypes, conducted performance trials, and simulated nest emergence in a field experiment. Tumoricidal activities of pterostilbene depend upon destabilizing the MTA1-NuRD complex and enhancing P53 acetylation in hepatocellular carcinoma. 2-D PAGE revealed 25 differential spots in Malviya dhan 36 and 36 spots in Shivani after O3 treatment with reductions in RuBisCO subunits. Sets of integrating plasmids and gene disruption cassettes containing improved counter-selection markers designed for repeated use in budding yeast. Infrared spectra and the chain organization of erythrocyte membranes. Female reproductive competition explains variation in prenatal investment in wild banded mongooses. Consistently, loss of JAK/STAT activity in Socs36E mutant clones severely impairs their self-renewal. The significant increase in mobility shown here may present a new route to producing faster and more efficient optoelectronic devices based on organic materials. Progesterone-Regulated Endometrial Factors Controlling Implantation.

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Kidney development is characterized by a mesenchymal-epithelial transition underlain by a cadherin-11 to cadherin-6 switch, the regulation mechanisms of which are presently unexplained. To investigate the association between peptic ulcer case volume per hospital, on the one hand, and in-hospital mortality and 14-day readmission rates, on the other, using a nationwide population-based dataset. To be able to compare the results from different linkage studies it is very import to verify the genetic background of the substrains used in those studies. These data suggest that urinary tract obstruction during active nephrogenesis results in a defect in ureteric duct branching morphogenesis, and altered vascularization of the glomerulus with consequent podocyte dropout and decreased glomerular number. After SPECT acquisition, the muscles containing the transplant were analyzed immunohistochemically and autoradiographically. We used hospital inpatient data for Arizona, California and Texas (2005-10) to estimate associations between homicide rates and the probability of hospitalization for ambulatory care sensitive (ACS) conditions. Accurate detection of Neisseria gonorrhoeae ciprofloxacin susceptibility directly from genital and extragenital clinical samples: towards genotype-guided antimicrobial therapy. Additionally, many athletes are likely returning to sport with residual atrophy of the BFLH and/or hypertrophy of the BFSH. Modifications of blood cholesterol in the differential diagnosis of neoplastic processes.

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1,3,6,8-TCDD and 1,3,7,9-TCDD) and the TEQ-based emissions at the outlet of a baghouse pollution control device. Physiological and behavioral responses to stress: what does a rat find stressful?. However, due to the complexities of the healing of osteoporotic fractures, animal models may be more appropriate for studying the effects of osteoporosis in more detail and for testing drugs on the fracture repair process. Calcium channel blockers such as nifedipine, nitrendipine and verapamil may have advantages as first-line drugs in the treatment of patients with an elevated risk for cerebral hypoperfusion, because of their selective action on vasoconstricted vessels and their differential effects in different regional vascular beds. No significant between-group difference was found in background liver function or type of hepatic resection. This increase in the incidence and the high associated mortality rate despite therapy has focused the attention on this disease and prompted investigators to undertake research aimed at understanding the pathogenesis of this disease as well as methods to treat it. Reverse total shoulder arthroplasty commonly treats cuff-deficient or osteoarthritic shoulders not amenable to rotator cuff repair. Resection or ablation in hepatocellular carcinoma: pro resection. This technology has been successfully applied to rabbits, swine, goats, sheep and cattle, situating genome editing in livestock species at an attainable distance, thereby empowering scientist to develop a myriad of applications.

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Pyrolysis of AL and KL produce more phenols at low temperature by the breakage of ether bonds. Antigenic structure of human gonadotrophins: pituitary luteinizing hormone. Diacetyl reductase in animal tissues and its intracellular distribution. Subjects included miners who had experience wearing SCSRs, manufacturers, and researchers. Understanding the complex relationships underlying hot flashes: a Bayesian network approach. The article presents some risk factors of breast cancer development and prognosis of the disease in Ukrainian patients. We conducted a multicenter, randomized, controlled trial to demonstrate the noninferiority of the omission of bursectomy.

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Priority of the casualties as well as given treatments could be indicated on the cards by movable markers, which also gave the time required for every treatment. However, we did not find, as reported elsewhere in the literature, a statistically significant difference between cases and controls as regards nasal symptoms and hyperemia of the nasal mucosa. Many acini were shrunken and contained cells with pyknotic nuclei. The histidine-modifying reagent, diethyl pyrocarbonate, reversibly blocks cx50 hemichannel currents but not cx46 hemichannel currents. Current evidence suggests that lipoteichoic acid (LTA) on the surface of Streptococcus pyogenes is centrally involved in the adherence of these bacteria to the oral mucosa. Three Czechoslovakian BCG strains, all originally derived from the Danish strain but thereafter and in distinction from it maintained on potato media, have now been investigated. Physalis alkekengi is an edible herb whose fruit and calyx are traditionally used to treat a wide range of diseases including inflammation, toothache, and rheumatism. We found no association of metabolites previously associated with waist circumference at 20 years and breastfeeding in early life.

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Cyclosporin A, in doses approaching toxic levels of 35 or 50 mg/kg/day for 14 days, prolonged function of the cardiac xenografts for median survival times of 21 and 11 days, respectively, in contrast to the median survival of 2 days in untreated recipients. When emulsifier concentration was increased, Ostawald ripening in emulsions containing emulsifiers with small hydrophilic groups was inhibited, while size increment of droplets in emulsions containing emulsifiers with large hydrophilic groups was not. Here, we report the first documented case of modified liver-free multivisceral transplantation preceded by neoadjuvant 177-lutetium peptide receptor radionuclide therapy in a patient with a small bowel neuroendocrine tumor and extensive lymph node metastases in the mesenterium. An interaction map of circulating metabolites, immune gene networks, and their genetic regulation. The advantages and limitations of the developed solution, as well as the possibilities of its practical use, are listed. Arthroscopic discectomy and interbody fusion of the thoracic spine: A report of ipsilateral 2-portal approach. In the case of D-glucose, average substitution levels of up to 53 mol glucose/mol bovine serum albumin were obtained.

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In contrast, soft tissue cells (human gingival or dermis fibroblasts) were less affected by the same coating, despite a moderate reduction in initial adhesion of gingival fibroblasts. Equine antihuman thymocyte globulin, prednisolone, and azathioprine were used for immunosuppression. Primary tumor resection (PTR) is currently recommended for patients with unresectable stage IV colorectal cancer (CRC) who present symptoms related to their primary tumor (eg, obstruction, perforation, significant bleeding). Anti-bacterial and cytotoxic properties of plasma sprayed silver-containing HA coatings. The purpose of the current study was to retrospectively investigate clinical outcome and potential prognostic factors after reirradiation (Re-RT) for in-field recurrence of metastatic spinal cord compression (MSCC). Clinical dietitians should be versatile regarding all test diets that may influence diagnostic test outcome. Here we show that SDF-1 is expressed by the vascular endothelium from selected healthy and tumor tissues. This article reviews the two most common distance measures employed for the calculation of biodistances based on nonmetric traits, the mean measure of divergence (MMD) and the tetrachoric Mahalanobis D(2) distance (TMD). We establish the consistency and asymptotic normality of the penalized estimator and prove its oracle property. A provisional matrix was developed, including both health and health determinant indicators, which allowed to show how some neighbourhoods in the city systematically fare worse for most of the indicators while others systematically fare better.

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Macular edema that did not respond to two or more consecutive intravitreal bevacizumab injections was treated with intravitreal TA. Randomised controlled trials and quasi-experimental studies were identified through computerised database searches. Several investigators and the Select Committee on GRAS Substances suggest that the incidence of salt-dependent hypertension could be significantly decreased in a society such as ours if salt intake were reduced from the present level of approximately 10 g/day to 12 g/day. We describe here the abnormalities of mast cells observed in MITF mutant mice. We studied the effect of acetazolamide on plasma potassium in normals and in two patients with hyperkalemic periodic paralysis. Workers occupationally exposed to cadmium, cobalt and lead have been reported to have increased levels of DNA damage. Following the unprecedented rise in photovoltaic power conversion efficiencies during the past five years, metal-halide perovskites (MHPs) have emerged as a new and highly promising class of solar-energy materials. In addition to providing information on current treatments for panic disorder and the main underlying treatment issues, the article identifies areas where improvements need to be made and areas where much research has been conducted in recent years. Contribution of the excluded volume of bovine serum albumin for solute molecules to the urispas 200mg dose aprent nonsolvent water. Transition Metal Catalyzed, Regioselective B(4)-Halogenation and B(4,5)-Diiodination of Cage B-H Bonds in o-Carboranes.

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Mass spectrometry, associated with 2D-DIGE analysis of carcinomas and normal adrenals, identified 22 proteins in 27 differentially expressed 2D spots, mostly overexpressed in ACC. This study investigated the prevalence and effect of preoperative partial-thickness RCTs and muscular degenerative changes on postoperative outcomes after TSA. Risk factors of early recurrence after curative hepatectomy in hepatocellular carcinoma. Tools for the Individualized Therapy of Teicoplanin for Neonates and Children. Peritoneal carcinomatosis (PC) arising from the appendix is a rare disease for rocaltrol tab uses which the long-term prognosis is poor. However, the clinical significance of NANOG overexpression in lung cancer has been scarcely evaluated.

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The data support acupuncture/EA as a complementary therapy for CIP. This latter function seems to be dependent on lysosomal proteases, which need to be released into the cytosol for apoptosis to be efficient. This chapter presents the burden of TBI as regards age group, gender, costs, race, emergency department (ED) visits, hospitalizations, and deaths. Renal cell carcinoma may adapt to and overcome anti-angiogenic intervention with thalidomide. Overexpression of Pgp results in reduced intracellular drug concentration and cytotoxicity of chemotherapeutic drugs and is thought to contribute to multidrug resistance of cancer cells.

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