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Cytoxan (Cyclophosphamide)
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Cytoxan

Cytoxan is a medication used as chemotherapy and to suppress the immune system. As chemotherapy it is used to treat lymphoma, multiple myeloma, leukemia, ovarian cancer, breast cancer, small cell lung cancer, neuroblastoma, and sarcoma. As an immune suppressor it is used in nephrotic syndrome, granulomatosis with polyangiitis, and following organ transplant.

Other names for this medication:
Cyclomet, Cyclophosphamide, Cycloxan, Cycram, Cycrame, Cydoxan, Cyphos, Eldamide, Endoxan, Ledoxan, Neophos, Neosar, Oncomide, Oncophos, Oncoxan

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Also known as: Cyclophosphamide

Description

Cyclophosphamide is used to treat cancer of the ovaries, breast, blood and lymph system, and nerves (mainly in children). Cyclophosphamide is also used for retinoblastoma (a type of eye cancer mainly in children), multiple myeloma (cancer in the bone marrow), and mycosis fungoides (tumors on the skin). It belongs to the group of cancer medicines called alkylating agents.

Cyclophosphamide is also used for some kinds of kidney disease.

Cyclophosphamide interferes with the growth of cancer cells, which are then destroyed by the body. Since the growth of normal body cells may also be affected by cyclophosphamide, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, like hair loss, may not be serious but may cause concern. Some effects may not occur for months or years after the medicine is used.

Before you begin treatment with cyclophosphamide, you and your doctor should talk about the benefits of this medicine as well as the risks of using it.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain cyclophosphamide. It may not be specific to Cytoxan Lyophilized. Please read with care.

Take this medicine only as directed by your doctor. Do not take more or less of it, and do not take it more often than your doctor ordered. The exact amount of medicine you need has been carefully worked out. Taking too much may increase the chance of side effects, while taking too little may not improve your condition.

Cyclophosphamide is sometimes given together with certain other medicines. If you are using a combination of medicines, make sure that you take each one at the proper time and do not mix them. Ask your doctor to help you plan a way to remember to take your medicines at the right times.

While you are using cyclophosphamide, it is important that you drink extra fluids so that you will pass more urine. Also, empty your bladder frequently, including at least once during the night. This will help prevent kidney and bladder problems and keep your kidneys working well. Cyclophosphamide passes from the body in the urine. If too much of it appears in the urine or if the urine stays in the bladder too long, it can cause dangerous irritation. Follow your doctor's instructions carefully about how much fluid to drink every day. Some patients may have to drink up to 7 to 12 cups (3 quarts) of fluid a day.

Usually it is best to take cyclophosphamide first thing in the morning, to reduce the risk of bladder problems. However, your doctor may want you to take it with food in smaller doses over the day, to lessen stomach upset or help the medicine work better. Follow your doctor's instructions carefully about when to take cyclophosphamide.

Cyclophosphamide often causes nausea, vomiting, and loss of appetite. However, it is very important that you continue to use the medicine even if you begin to feel ill. Do not stop taking this medicine without first checking with your doctor. Ask your doctor for ways to lessen these effects.

If you vomit shortly after taking a dose of cyclophosphamide, check with your doctor. You will be told whether to take the dose again or to wait until the next scheduled dose.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets): For the treatment of cancer: Adults—Dose is based on body weight and must be determined by your doctor. The usual dose is 1 to 5 milligrams (mg) per kilogram (kg) of body weight per day. Children—Dose is based on body weight and must be determined by your doctor. The usual dose is 1 to 5 mg per kg of body weight per day.

Overdose

If you overdose Cytoxan and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Cytoxan dosage information

Side effects

The most common side effects associated with Cytoxan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of cyclophosphamide in the elderly with use in other age groups, it is not expected to cause different side effects or problems in older people than it does in younger adults.

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Results suggest that resection arthroplasty without interposition may be as effective as other operative treatment options for patients with fourth and fifth TMT pathology. The Sex-Specific Impact of Aging on the Blood Pressure Response to Exercise. Post-surgery course was free of complications, followed by adjuvant chemotherapy. Anatomic distribution of BCC is consistent with general levels of sun exposure across body sites. Risk stratification using these data can identify patients with aggressive CLL who require careful monitoring and are unlikely to have durable responses to chemoimmunotherapy at disease progression. Our hope is that the lessons learnt from our experience in Boston can help others do even better.

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Eleven of 12 were diagnosed preoperatively on computerized tomography by the triad of air in the bladder, thickened colon adjacent to an area of thickened bladder, and the presence of colonic diverticula. Self-expandable metallic stents (SEMS) have been widely accepted as palliation therapy for malignant gastric outlet obstruction (GOO). It will provide important information in cancer research, cancer diagnosis, and therapy. A decade of antimicrobial susceptibilities at the University of Kentucky Hospital. Conversely, Dynamic Light Scattering is not able to provide reliable results for these systems due to the presence of the biological components in solution. We retrospectively analyzed the medical records of 478 patients treated with CTRX to assess the incidence and risk factors of CTRX-associated BPL. Assessment of fetal anatomy in the first trimester using two- and three-dimensional ultrasound.

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Our data provide the missing reference intervals and enable the use of the nephelometric IgG subclass reagents in Chinese. Using a new ear artery ligation model and the classic hindlimb ischemia model in mice, we noted that MCP-1 expression is significantly increased in collateral arterioles undergoing arteriogenesis already 24 hours after its onset. Heart in space: effect of the extraterrestrial environment on the cardiovascular system. To determine the results of corneal graft survival after penetrating keratoplasty for Peters anomaly. The BALB/cJ inbred mouse strain is a useful model system for testing the relationship between reduced sociability and CC underdevelopment. Central corneal pachymetry with slit lamp-adapted OCT revealed, for clinical purposes, an excellent accuracy and reproducibility with a high degree of agreement compared with US pachymetry. Improving Surgical Outcome Using Diffusion Tensor Imaging Techniques in Deep Brain Stimulation.

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Since the effects of insulin on proliferation were opposite in the two lines, we propose at least two distinct sites of insulin action on the cells. After a two-step selection process, eight studies were identified. The incidence and antiviral response in SLE patients with hepatitis C virus (HCV) reactivation is unclear and needs to be investigated. LLLT decreased the severity of OM and oral pain in elderly HNC patients. Pyroglutamyl-beta-naphthylamide hydrolyzing activity (pGluHA) is reported to be capable of removing the amino-terminal pyroglutamic acid residue from peptides (e.g. Progestins, notably progesterone (P4) and 17 alpha hydroxyprogesterone caproate, are presently used to treat pregnant women at risk of preterm birth. For each technique, the structure and mechanical integrity of fabricated scaffolds are discussed in detail. More than a two-fold prolongation in the survival time of the grafted skin was obtained by a single 100 microgram dose of Con-A given intravenously to mice 24 h prior to grafting. Patients were considered users of CMT if they reported that either partner used at least one type of CMT for treating infertility. Tight fixation, as provided by Nitinol prostheses leads to improved functional results because of better sound transmission properties at the incus-prosthesis interface.

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Medline and EMBASE databases were searched for articles published between 1989 and November 2016. The availability of an assay for serum prednisolone, together with a knowledge of the ratio between these two clearances, may prove useful for regulating therapy in renal transplant patients. Small interfering RNA-mediated depletion of Smad1 in SSc fibroblasts normalized the production of CCN2 and collagen. Irreversible HER/erbB inhibitors selectively inhibit HER-family kinases by targeting a unique cysteine residue located within the ATP-binding pocket. Multilevel analysis modeled the relationship between does lamictal xr have a generic relational bullying and HRQL. USE OF AMOXICILLIN AND CLAVULANIC ACID (AUGMENTIN) IN THE TREATMENT OF SKIN AND SOFT TISSUE INFECTIONS IN CHILDREN.

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At low temperatures we find in both superconducting materials a saturation of the relaxation time, suggesting the presence of a second relaxation channel not due to electron-phonon interaction. Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy in Vivo. He lists the ten tasks contracted for with UNOS, and explains three of the tasks and their implications for professionals and facilities involved in transplantation. This paper investigates the structural characteristics of templated synthetic anti-ferromagnetic (SAF) magnetic nanoparticles fabricated on two different release layers. Our data strongly support further study of NDGA as a potential therapeutic against breast cancers that have progressed on trastuzumab. This paper reviews the general literature in health economics and public economics about the use of CEA for priority setting in public health, in order better to inform current debates about resource allocation in the fight against HIV/AIDS. Comparative efficacy and acceptability of antidepressant treatment in poststroke depression: a multiple-treatments meta-analysis. Also, the medium-sized carcasses were discernable throughout the 81-day study period, indicating that it is possible to detect bodies undergoing decomposition with side-scan sonar. Longitudinal Validation of the Spanish arcoxia 60 mg obat untuk apa Version of the Health-Related Quality of Life Questionnaire for Hymenoptera Venom Allergy (HRQLHA). This paper gives a critical account of the two major programs so far published specifically to estimate the parameters of enzyme kinetics.

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A total of 14,374 adult patients admitted between January 2001-November 2006. When laboratory tests can mislead even when they appear plausible. The present study of patients with Wenckebach-type second-degree sinoatrial block (W-block) evaluated the probability of the development of a more advanced grade of sinoatrial block. The long-term neurological prognosis of severe fetal anemia is usually considered favorable, especially when fetal hydrops regresses after successful in utero transfusion. The mesocolon and third portion of the duodenum were strongly pulled down into giant inguinal hernia, probably causing the rupture of the inferior duodenal angle. Surgical relevance Perforator flap failure is mainly the result of impaired blood supply, as a flow-end blood configuration is nourished only by the perforator terminal branch of the artery.

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Trapeziometacarpal joint osteoarthritis: treatment with tendon interposition arthroplasty according to Ceruso in severe osteoarthritis. C-H activation assisted by a bifunctional directing group has allowed the construction of heterocycles. Effect of glucose 6-phosphate on the nucleotide site of glycogen phosphorylase b. Diagnosis usually requires a high index of suspicion, particularly in post irradiated patients. Because of specific can i take 80 mg of protonix a day peculiarities such as different pathophysiology, fragility of the aneurysmal wall, high risk of intraoperative bleeding, and high probability of losing parent vessel patency, their treatment is controversial, and both endovascular and surgical options have been reported. To monitor the activity of the humoral component in graft dysfunction following renal transplantation using live related donors, flowcytometric cross-match procedure was adopted. We show here that the alternative sigma factor sigmaE (sigma24, RpoE) also facilitates the survival of Salmonella typhimurium under conditions of nutrient deprivation. Simultaneous rupture of the heart septum and the free wall of the right ventricle in a patient with acute myocardial infarct.

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The use of an osteocutaneous free fibular graft as a single-stage reconstructive procedure for composite tissue loss is increasingly common. The effect of apigenin on the single gut bacteria strains Bacteroides galacturonicus, Bifidobacterium catenulatum, Lactobacillus rhamnosus GG, and Enterococcus caccae, was examined by measuring their anaerobic growth profiles. This study thus analyzed whether the loop technique could preserve mitral leaflet mobility on trans-thoracic echocardiography. In LCH, involvement of the calvaria, skull base, maxillofacial bones, and hypothalamic-pituitary axis is fairly common. The assessment was done using a standardized checklist containing five criteria and 68 indicators. After decades of use, decaBDE and other members of its polybrominated diphenyl ether class have become globally-distributed environmental contaminants that can be measured in the atmosphere, water bodies, wildlife, food staples and human breastmilk.

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Ileal autoplasty of a sclerotic urinary bladder in the presence of a traumatic spinal cord lesion. Finally, the phase shifting effects of microinjection of muscimol into the suprachiasmatic nucleus during the subjective day were blocked by a subsequent light pulse. Emergency separation of thoracopagus (twins conjoined at thorax) in the newborn period: importance of careful preoperative cardiac evaluation. The aim of the present study was to determine whether the relaxation to estrogen is differently modified between male and female genders after long-term resveratrol treatment. We compared offline decoding performance between these two physiologically defined populations of cells. Laparotomy was performed immediately and a right tubal pregnancy was confirmed. Kidney transplantation significantly improves renal function and may therefore reduce periodic limb movements. The proposed recovery indicators can be utilized by both practitioners and researchers to effectively track post-disaster recovery. In one activity, participants were asked to engage with language and to think of alternative words (or euphemisms) that are used to describe death.

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Effects of Light and Electron Beam Irradiation on Halide Perovskites and Their Solar Cells. We more recently reported similar findings in the fruit fly Drosophila melanogaster, which lacks adaptive immunity, after an infection with Drosophila C virus. The GAP domain of DEPDC1B interacted with nucleotide-bound forms of RAC1 in vitro. Spontaneous albendazole pinworm treatment dose motor activity in white rats in relation to sex and age. The expression level of early osteogenic marker genes, ALP, Runx2, and type I collagen, which play a critical role in MSC to osteoblast transition and servers as a downstream target of BMP signaling, was significantly induced by OA. This issue could potentially be resolved by simulating specific configurations of multiple seeds or by constraining the treatment planning to avoid these configurations, which could make the proposed method competitive with CT-based seed localization. The clinical and biochemical features of these diseases are described.

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The Role of Epigenetic Regulation in Epstein-Barr Virus-Associated Gastric Cancer. Loss-of-function alleles of deubiquitinase DUSP31 were identified as suppressors of the Dronc overexpression phenotype. Severe right ventricular inflow obstruction by non-Hodgkin lymphoma. These trials may provide insight on the future role of telestroke, for intravenous thrombolysis and remote imaging review of multimodal computed tomography or MRI to streamline patient transfer for endovascular therapy. Perceived health risk and health self-efficacy significantly influence the health information-seeking behavior intention of consumers. On the other hand, the assembly of BNPs shows significant differences from molecular assembly due to their large dimension, complex geometry, and multi-scale interactions involved in the assembly process. The contribution of carbon assimilation and allocation and of invertases to the stimulation of adventitious root formation in response to a dark pre-exposure of petunia cuttings was investigated, considering the rooting zone (stem base) and the shoot apex as competing sinks. Thumb Function and Electromyography Result after Modified Camitz Tendon Transfer.

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The bi-iliac distance and the iliac bone position have not previously been described in Ullrich-Turner syndrome fetuses. To determine the maternal and perinatal outcomes associated with delivery by the rigid plastic OmniCup vacuum delivery device. Viral hepatitis infection is associated with cellular inflammation, oxidative stress, and DNA damage, that may lead to subsequent hepatic injuries such as chronic hepatitis, fibrosis, cirrhosis, and finally HCC. None the less, most species have genetic barriers to prevent selfing. Changes in tocopherol levels in platelets most closely followed changing dietary intakes of vitamin E when compared with data from RBC, lymphocytes, and plasma. Nitrendepine partially inhibited the rise in calcium caused by acetylcholine, and prevented the enhancement of the rise following pertussis toxin treatment. rhBMP-2/BCB was implanted in the left thigh muscle pouch in the study group and BCB in the control group. The occurrence of CEA was extensively adsorbed to eliminate cross-reactions with CEA-related antigens. Vein graft disease limits the late results of coronary revascularization. The oxidation of methionine-54 of epoetinum alfa does not affect molecular structure or stability, but does decrease biological activity.

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Explanatory variables for post-CPB lung dysfunction were coronary arterial bypass, pleura opening, static pulmonary compliance measured at the time of thorax closed then retracted, fluid infusion, transfusion and vasopressors. Ideal Standards, Acceptance, and Relationship Satisfaction: Latitudes of Differential Effects. Radial Artery Occlusion After Transradial Interventions: A Systematic Review and Meta-Analysis. Hepatitis E virus (HEV) is an emerging pathogen and an increasingly recognized cause of graft hepatitis, especially in the post-orthotopic liver transplantation immunocompromised population. One leiomyoma was characterized by moderately to severely pleomorphic atypical tumor cells with low mitotic counts and no coagulative tumor cell necrosis. The regioselective functionalization of the N1 and N5 ring nitrogens and the C3 amino group is demonstrated in the synthesis of an interleukin-1beta converting enzyme inhibitor 13. Photoallergic Contact Dermatitis Due to Chlorpromazine: A Report of 2 Cases.

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