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Daklinza (Daclatasvir)
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Daklinza

Daklinza is used for the treatment of patients with chronic Hepatitis C virus (HCV). Daklinza inhibits the Hepatitis C Virus (HCV) nonstructural protein; by targeting two steps of the viral replication process, enabling rapid decline of HCV RNA.

Other names for this medication:
Daclatasvir

Similar Products:
Cialis, Decadron, Adipex, Avelox, Zebeta, Starlix, Xanax

Also known as: Daclatasvir

Description

{name} (daclatasvir) is an antiviral medicine that prevents hepatitis C virus (HCV) from multiplying in your body.

{name} is used in combination with other medications to treat chronic hepatitis C in adults.

{name} treats specific genotypes of hepatitis C, and only in certain people. Use only the medications prescribed for you. Do not share your medicine with other people.

{name} must be given in combination with other antiviral medications and should not be used alone. It is usually given with sofosbuvir, with or without ribavirin.

{name} is sometimes used in people who also have HIV. Daclatasvir is not a treatment for HIV or AIDS.

Dosage

Usual Adult Dose for Chronic Hepatitis C:

60 mg orally once a day Recommended Regimen and Duration of Therapy: Genotype 1: -Without cirrhosis: Daclatasvir plus sofosbuvir for 12 weeks -Compensated (Child-Pugh A) cirrhosis: Daclatasvir plus sofosbuvir for 12 weeks -Decompensated (Child-Pugh B or C) cirrhosis: Daclatasvir plus sofosbuvir plus ribavirin for 12 weeks -Posttransplant: Daclatasvir plus sofosbuvir plus ribavirin for 12 weeks Genotype 3: -Without cirrhosis: Daclatasvir plus sofosbuvir for 12 weeks -Compensated (Child-Pugh A) or decompensated (Child-Pugh B or C) cirrhosis: Daclatasvir plus sofosbuvir plus ribavirin for 12 weeks -Posttransplant: Daclatasvir plus sofosbuvir plus ribavirin for 12 weeks Comments: -Dose recommendations also apply to HCV/HIV-1-coinfected patients. -Optimal duration of therapy has not been established for HCV genotype 3-infected patients with cirrhosis or for HCV genotype 1-infected patients with Child-Pugh C cirrhosis. -The manufacturer product information for sofosbuvir should be consulted regarding dosing. The manufacturer product information should be consulted regarding ribavirin dosing and dose adjustments (if applicable). Use: With sofosbuvir (with or without ribavirin), for the treatment chronic HCV genotype 1 or 3 infection

Detailed Daklinza dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Daklinza are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Using this medicine will not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent hepatitis C transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

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Role of P53 functionality in the genotoxicity of metronidazole and its hydroxy metabolite. These algorithms provide good speedup and scale well to a large number of processors. A before (stage 1) and after (stage 2) interventional study was performed in 10 tertiary care hospitals. Many synthetic peptides have been developed for diagnosis and therapy of human cancers based on their ability to target specific receptors on cancer cell surface or to penetrate the cell membrane. Both PGI2 and PGF2 alpha have been effective in fractions of pg/kg, the former showing a protective and the latter a destabilizing activity. Affinity capillary electrophoresis (ACE) with laser-induced fluorescence polarization (LIFP) detection is described, with examples of affinity interaction studies. Nanotoxicology and Metalloestrogens: Possible Involvement in Breast Cancer. Over a range of stimulation frequencies around the intrinsic frequency of an aggregate we find one action potential for each stimulus with a fixed latency from each stimulus to the subsequent action potential. Simulation of penicillin production in fed-batch cultivations using a morphologically structured model.

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Impact of Bt-corn MON88017 in comparison to three conventional lines on Trigonotylus caelestialium (Kirkaldy) (Heteroptera: Miridae) field densities. Here we summarize and highlight the current understanding of the interplay between common tumor microenvironmental factors and oncogenic pathogens in promoting tumorigenesis. At the crystal edge a local distortion of the crystal lattice is responsible for a widening of the optical bandgap and faster photo-carrier recombination. A cautious policy should be followed in correcting these deformities, since dislocation of the eponychium together with damage to the nail matrix and the nail bed play a complex role in the process of deformation. The 5-year survival rate in long-term follow-up is favorable, despite an initially elevated complication rate. Smart Parasitic Nematodes Use Multifaceted Strategies to Parasitize Plants. An improved light microscopical histoquantitative method for the analysis of the stereologic structure of the ventral lobe of the rat prostate is introduced. Presumably owing to conjugation with bacterial GHS, FDNB in concentrations which were lower or equal to those of bacterial GSH were found to be not mutagenic. Moreover, while cationic amino-acids easily protonate amide dioxetanone, anionic ones cannot deprotonate the neutral species.

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While Human African Trypanosomiasis (HAT) is in decline on the continent of Africa, the disease still remains a major health problem in Uganda. Prevention of posttraumatic pulmonary platelet trapping by portacaval transposition. The use of human cytokines in feline medicine has been of limited success as the action of cytokines is often species restricted or their activity may be neutralized due to antibody formation. In the discussion they mention the relationship of this tumour to gastrointestinal stromal tumours. The model is also used to perform a what-if analysis to assess the efficacy of timely intervention policies. The S100A4 protein as well as the matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are associated with diseases such as arthritis and cancer.

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Cell proliferation and cartilaginous nodule production in MPC and LPC explants in monolayer culture were compared. Alpha-casein-binding proteins of guinea pig macrophage membranes and their possible roles in chemotaxis. The autopsy demonstrated that the low abdominal wall was broken and a large amount of intestine herniated out of the abdominal cavity. Catheter biopsy from the bronchial tree by a modified Friedel technic. Head measurements and other growth data collected at the time of detection and over the period of pouch life indicates the time from removal of the male and the date of birth to be between 50 and 77 days. This case will highlight the importance of early recognition and considerations regarding patient management for this differential of radiating low back pain. intercessory prayer) or for psychiatric disorders were excluded.

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These results suggest that nociceptin more potently blocks the ability of reward-associated cues than aversion-associated cues to influence behavioral biases. The evidence suggests that MGF has a high potency for inducing local protein synthesis and preventing apoptosis and therefore has an important role in local tissue repair and remodeling. Spontaneous spinal epidural hematoma (SSEH) is an acute neurological emergency which carries significant morbidity unless diagnosed and treated in a timely fashion. The results of implementing these criteria with data, however, suggest that., in the case of orthogonal rotation, the considerable constraints render solutions based on various special cases of the general criterion quite similar to one another. Good agreement with numerical simulations validates this method for the parameters considered. Percutaneous vertebroplasty, kyphoplasty and lordoplasty: implications for the anesthesiologist. L-dopa-induced accumulation of 3-O-metyldopa in brain and heart. Patellar tendon or hamstring graft anterior cruciate ligament reconstructions in patients aged above 50 years. Here, we challenge that view and show that the probability of electrical coupling is the same within and between regular-spiking (RS) and fast-spiking (FS) cortical INs in 16-21 days old mice. Taking into account that a majority of people in industrialized countries suffer from a shortage in vitamin D even in summer time, the ratio Evd/Eer is a new and important criterion for the quality of sunscreens.

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This ability to manipulate neuronal phenotype is being used in an attempt to identify cell surface macromolecules that are important in the development or function of adrenergic and cholinergic properties. Morphologic features in biopsy diagnosis of acute viral hepatitis. The MD-ME-EC device was then used on-animal to monitor the subdermal metabolism of nitroglycerin in sheep. ELISA seems to be a simple, sensitive and economic method for quantitation of enterotoxins and toxin-specific antibodies. Retrospective study including patients treated with radial flaps in the Department of Head and Neck Surgery in Erlangen from January 2005 to August 2013. Packing of alpha-helices onto beta-pleated sheets and the anatomy of alpha/beta proteins. There is little research on both levels of social support following treatment and the association between social support and emotional well-being over time following breast cancer diagnosis and treatment. Considerable controversy is ongoing regarding optimal initial warfarin dosing for patients with acute deep venous thrombosis (DVT) and pulmonary embolism (PE). Nutritional disorders caused by dysphagia may lead to a poor prognosis.

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We discuss the implied roles of visuospatial information processing capacity, neural coactivation, and propensity for conscious processing during performance of complex motor tasks. Comparative structural analysis of psychrophilic and meso- and thermophilic enzymes. The Effects of GLCM parameters on LAI estimation using texture values from Quickbird Satellite Imagery. For Sweden, this has been estimated to be 400,000 at any one time, often in areas known to be risk zones for natural disasters and terrorism. In previous studies it had been found that C57B1/6 marrow cells, normally resistant to infection by the Friend virus (FV-P), became susceptible after their transplantation into lethally irradiated leukemic DBA/2 mice. We collected all feedback letters sent to the GP concerning children who underwent the Pulmocheck in 2010, 2011 and 2012. Abnormal cell lineages in mutants of the nematode Caenorhabditis elegans. Theoretically at least, the shown calculation procedure can be applied to other thermal preservation methods and to the prediction of collateral biochemical reactions, like vitamin degradation or the synthesis of compounds that cause discoloration. The increase in understanding of the events of cell growth and division has enabled the development of pharmacological agents inhibiting key regulatory proteins, with the cyclin dependent kinases (CDKs) representing a major area of interest.

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Computing DIT from energy expenditure measures in a respiratory chamber: a direct modeling method. A glutamate receptor subtype antagonist inhibits seizures in rat hippocampal slices. Introduction of audio gating to further reduce organ motion in breathing synchronized radiotherapy. Furthermore, DDA3 targets Ska1 to KTs to stabilize end-on attachment. Primary health care development in 2002-2006 in Lithuania: will we achieve the objective set?. Transforming Health Care: Body Sensor Networks, Wearables, and the Internet of Things. The incidence of A fib increases as the population ages, which creates an increased need for clinicians to understand the place of antiarrhythmic therapy in management of A fib. Induction Hedgehog pathway inhibition followed by combined-modality radiotherapy for basal cell carcinoma. The survey also inquired as to which states formally recognize specialty receiving facilities for trauma, STEMI, stroke, cardiac arrest, and burn as well as whether or not states have mandatory or model statewide destination protocols for these specialty centers. Recent studies in mice showed that the Ten-eleven translocation Enzymes (TET) family is involved in the active DNA demethylation.

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