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Diaformin (Metformin)

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Diaformin is an anti-diabetic medication (biguanide). It works by lowering glucose production in the liver, delaying the absorption of sugar (glucose) from the intestines, and increasing the body's sensitivity to insulin.

Other names for this medication:
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Also known as: Metformin


{name} XR is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

{name} XR is sometimes used together with insulin or other medications, but this medicine is not for treating type 1 diabetes.


Usual Adult Dose for Diabetes Type 2:

Immediate-release: Initial dose: 500 mg orally twice a day or 850 mg orally once a day Dose titration: Increase in 500 mg weekly increments or 850 mg every 2 weeks as tolerated Maintenance dose: 2000 mg daily in divided doses Maximum dose: 2550 mg/day Extended-release: Initial dose: 500 to 1000 mg orally once a day Dose titration: Increase in 500 mg weekly increments as tolerated Maintenance dose: 2000 mg daily Maximum dose: 2500 mg daily Comments: -Metformin, if not contraindicated, is the preferred initial pharmacologic agent for treatment of type 2 diabetes mellitus. -Immediate-release: Take in divided doses 2 to 3 times a day with meals; titrate slowly to minimize gastrointestinal side effects. In general, significant responses are not observed with doses less than 1500 mg/day. -Extended-release: Take with the evening meal; if glycemic control is not achieved with 2000 mg once a day, may consider 1000 mg of extended-release product twice a day; if glycemic control is still not achieve, may switch to immediate-release product. Use: To improve glycemic control in adults with type 2 diabetes mellitus as an adjunct to diet and exercise.

Usual Pediatric Dose for Diabetes Type 2:

10 years or older: Immediate-release: Initial dose: 500 mg orally twice a day Dose titration: Increase in 500 mg weekly increments as tolerated Maintenance dose: 2000 mg daily Maximum dose: 2000 mg daily Comments: Take in divided doses 2 to 3 times a day with meals. Titrate slowly to minimize gastrointestinal side effects. Safety and effectiveness of Diaformin extended-release has not been established in pediatric patients less than 18 years of age. Use: To improve glycemic control in children with type 2 diabetes mellitus as an adjunct to diet and exercise.

Detailed Diaformin dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can cause severe hypoglycemia or lactic acidosis.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Diaformin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use MetFORMIN (Eqv-Diaformin XR) if you are allergic to it, or if you have:

severe kidney disease; or metabolic acidosis or diabetic ketoacidosis (call your doctor for treatment).

If you need to have surgery or any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking MetFORMIN (Eqv-Diaformin XR). Be sure your caregivers know ahead of time that you are using this medication.

Tell your doctor if you have ever had:

kidney disease (your kidney function may need to be checked before you take this medicine); high ketone levels in your blood or urine; heart disease, congestive heart failure; liver disease; or if you also use insulin, or other oral diabetes medications.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, a severe infection, chronic alcoholism, or if you are 65 or older. Ask your doctor about your risk.

Follow your doctor's instructions about using this medicine if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby.

MetFORMIN (Eqv-Diaformin XR) may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.

You should not breastfeed while using this medicine.

MetFORMIN (Eqv-Diaformin XR) should not be given to a child younger than 10 years old. Some forms of MetFORMIN (Eqv-Diaformin XR) are not approved for use by anyone younger than 18 years old.

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N-myristoyltransferases (NMT) catalyze co- or post-translational myristoylation of Src family kinases and other oncogenic proteins, thereby regulating their function. Interaction of noradrenaline, NPY and VIP with the neurogenic cholinergic response of the rat uterine cervix in vitro. The genetic modification and characterization of T-cells with chimeric antigen receptors (CARs) allow functionally distinct cost of klonopin without insurance T-cell subsets to recognize specific tumor cells. Interestingly, another pre-synaptic inhibitory network mediating prepulse inhibition (PPI) remained unaffected. The rare patients with only partial portal thrombosis can be treated directly with stenting through an angioradiologic approach. Cryoablation of lung malignancies recurring close to surgical clips following surgery: Report of three cases. Glomerular permeability to serum proteins and high molecular weight dextrans in glomerulonephritis. Strain rate dependent hyperelastic stress-stretch behavior of a silica nanoparticle reinforced poly (ethylene glycol) diacrylate nanocomposite hydrogel. There is a need for larger randomised controlled trials to address these issues.

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However, the issue of where specifically NF-B is activated is unclear. Insulin and myoelectric activity of the small intestine of the pig. aureus which were further tested against 20 commercially available antibiotics to determine antibiotic susceptibility patterns. IV cefazolin was initiated and the patient recovered without sequelae. In this paper, we present the results of cellular and molecular studies on the neuroendocrine correlates of male sexual polymorphism in a population of the blenniid fish Salaria pavo (Risso). Frequency and type of serious infections in fludarabine-refractory B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma: implications for clinical trials in this patient population. Due to the lack of definitive biomarkers for AD, it is very difficult to set up standard diagnostic criteria for AD which cover the entire spectrum of AD patients. The susceptibility of structural concrete to early-age cracking depends on material composition, methods of processing, structural boundary conditions, and a variety of environmental factors. In this paper, we seek to re-conceptualize the ethical framework through which ethicists and medical professionals view the practice of live kidney donations.

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