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Fosamax (Alendronate)

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Fosamax is FDA-approved for the treatment of postmenopausal osteoporosis, prevention of postmenopausal osteoporosis, steroid-induced osteoporosis, male osteoporosis, and Paget disease of the bone. Fosamax is available under the following different brand names.

Other names for this medication:
Alant, Alendix, Alendronate, Alenost, Bifosa, Denfos, Osteofos, Ostogee, Poronil, Ralenost, Restofos, Zophost

Similar Products:
Casodex, Acticin, Daklinza, Tofranil, Lopid, Kamagra, Ditropan, Periactin

Also known as: Alendronate


{name} Plus D contains a combination of alendronate and cholecalciferol. Alendronate is a bisphosphonate medicine that alters bone formation and breakdown in the body. This can slow bone loss and may help prevent bone fractures.

Cholecalciferol is a form of vitamin D, and is important for the absorption of calcium from the stomach and for the functioning of calcium in the body.

{name} Plus D is used to treat and prevent osteoporosis.


Generic Fosamax should be taken orally. It is recommended to take Generic Fosamax in liquid form once a week in the morning without food. It is recommended to take Generic Fosamax in tablets of 5-mg and 10-mg once a day in the morning without food. It is recommended to take Generic Fosamax in tablets of 30-mg and 70-mg once a week in the morning without food. It is recommended to take Generic Fosamax in tablets of 40-mg once a day in the morning for six months to treat Paget's disease of bone. If you want to achieve most effective results do not stop taking Generic Fosamax suddenly.


If you overdose Generic Fosamax and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Fosamax overdosage: heartburn, stomach pain, diarrhea, numbness, tingling, tight muscles in your face, irritability, unusual thoughts or behavior, nausea, muscle cramps, convulsions.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Fosamax are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Fosamax if you are allergic to alendronate, or if you have:

low levels of calcium in your blood (hypocalcemia); or problems with the muscles in your esophagus (the tube that connects your mouth and stomach).

Do not take Fosamax if you cannot sit upright or stand for at least 30 minutes. Fosamax can cause serious problems in the stomach or esophagus. You must stay upright for at least 30 minutes after taking this medicine.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

trouble swallowing; problems with your stomach or digestion; low levels of calcium in your blood; a dental problem (you may need a dental exam before you begin taking Fosamax); kidney disease; or any condition that makes it hard for your body to absorb nutrients from food (malabsorption).

In rare cases, this medicine may cause bone loss (osteonecrosis) in the jaw. Symptoms include jaw pain or numbness, red or swollen gums, loose teeth, or slow healing after dental work. The longer you use Fosamax, the more likely you are to develop this condition.

Osteonecrosis of the jaw may be more likely if you have cancer or received chemotherapy, radiation, or steroids. Other risk factors include blood clotting disorders, anemia (low red blood cells), and a pre-existing dental problem.

Fosamax has also been reported to cause fractures, or broken bones, in the large bones of the leg. Tell your doctor if you have any leg or groin pain while using Fosamax.

Talk with your doctor about the risks and benefits of using this medication.

It is not known whether Fosamax will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Stop using the medicine and tell your doctor right away if you become pregnant.

It is not known whether alendronate passes into breast milk or if it could harm a nursing baby. Ask your doctor about any risk.

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We present evidence for an abundant long-chain acyl-CoA synthetase (EC activity in Plasmodium knowlesi-infected simian erythrocytes. LTD(4) generated from EOS or cells of some other type might contribute to the development of phenotypic change in airway EOS. Here we investigate contributions of residues within and proximal to this pathway using single-channel kinetic analysis, site-directed mutagenesis, and thermodynamic mutant cycle analysis. This results in body image anxiety which may lead to social phobia. A group of 330 patients with a history of immediate allergic reactions to penicillins was studied by two evaluators from the same allergy unit using the following protocol: skin tests with major and minor determinants of benzylpenicillin (benzylpenicilloyl-poly l-lysine and minor determinant mixture), amoxicillin and ampicillin, and determination of specific IgE antibodies to penicillins, by CAP-FEIA, in serum. Stomata, valves on the plant epidermis, are formed through a series of differentiation events mediated by three closely related basic-helix-loop-helix proteins: SPEECHLESS (SPCH), MUTE, and FAMA. Some 14 months after operation the patient is completely asymptomatic on the minimum of medical therapy and is able to live normally.

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The results of ELISA and VN showed that humoral immune responses induced by Ad-A-spCap-W and Ad-A-CD40L-Cap-GMCSF-W were not significantly different from SH-strain, but Ad-A-spCD40L-spCap-spGMCSF-W could induce significantly higher humoral immune response than SH-strain. Cost efficiency of nursing homes: do five-star quality ratings matter?. Here we discuss why and how methods from the rapidly evolving field of visual analytics can help translational teams (consisting of biologists, clinicians, and bioinformaticians) to address the challenge of modeling and inferring heterogeneity in the proteomic and phenotypic profiles of patients with complex diseases. Time-resolved high harmonic spectroscopy of dynamical symmetry breaking in bi-circular laser fields: the role of Rydberg states. A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223. Compared with the existing spatial-wavenumber filter based damage evaluation methods, the proposed method requires no more than the multi-damage scattering signal and can be performed without depending on any wavenumber modeling or measuring. Searching the preferred anesthetic technique during one-lung-ventilation. A transposon-mediated system for flexible control of transgene expression in stem and progenitor-derived lineages.

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The clinical study of protraction face mask combining with MEAW technique to correct skeletal Class III malocclusion in the early permanent tooth. Hysterectomy and oophorectomy were performed with resolution of symptoms. VEGF and VEGF antibody were used in the VEGF group and VEGF antibody group respectively, then the blood flow of the fracture ends was measured by single photon emission computed tomography (SPECT) 8, 24, 72 hours, 1, 3, 5 and 8 weeks after fracture, the X-ray films of the fracture sites were taken after 1, 3, 5 and 8 weeks to observe the fracture healing. Side-chain transformations and deuterium labeling in the steroidal sapogenin series. Therefore, we aimed to identify miRNAs with the potential to predict recurrence in young patients. The objective of the study was to evaluate the impact of ILS and metformin intervention over 10 years in women with and without a history of GDM in the DPP/Diabetes Prevention Program Outcomes Study. When has it been studied about La Crosse Virus?: Bibliometric analysis of world scientific production. HER2 is an acutely sensitive Heat Shock Protein 90 (HSP90) client and HSP90 inhibition can overcome trastuzumab resistance.

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Surgical resection is the reference treatment but is the cause of a significant morbidity and mortality. Unusual angiographic appearance of scimitar syndrome associated with primitive hepatic venous plexus. Inherent acceleration of tumor dose-rate in hyperfractionated regimens. In contrast to platelet-derived fully-sulfated chondroitin sulfate A, low-sulfated chondroitin sulfate A present in plasma was almost inactive. The approximation of the OTF using the first-order Taylor expansion can simplify the relationship between the phase and OTF to linear relation, so that the aberration can be quickly solved. VisBOL designs can be exported to formats including PNG and SVG images to be embedded in Web pages, presentations and publications. As hormone concentration changes over time, this implies a partial dynamic basis for individual differences in visual mental imagery, any dependent cognition and mental disorders. The reliability of the maternal memory in a retrospective assessment of nutritional status. Polyvinylpyrrolidone-Based Bio-Ink Improves Cell Viability and Homogeneity during Drop-On-Demand Printing.

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Beta-blockers for heart failure with reduced, mid-range, and preserved ejection fraction: an individual patient-level analysis of double-blind randomized trials. Notwithstanding the factors that may adversely affect the results obtained by this technique, further insights regarding fetal oxygenation may be gained. Endogenous viral genes influence infection with avian leukosis virus. Functional and physical outcomes following use of a flexible CO2 laser fiber and bipolar electrocautery in close proximity to the rat sciatic nerve with correlation to an in vitro thermal profile model. This second article comprises (1) the physiologic contribution of the vessel wall to the prevention of thrombosis, particularly the role of prostacyclin, (2) the mechanisms of action of platelet-inhibitor drugs in the prevention of thrombosis, (3) the ideal dose and ideal therapeutic combinations of conventional platelet-inhibitor drugs, (4) other agents and new agents that inhibit platelet function, and (5) drug side effects. This study assessed both the association between the adenoma detection rate and the quality of bowel preparation and the risk factors associated with the adenoma detection rate in screening colonoscopy.

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The usefulness of the RDW as a predictor of perioperative stroke in patients with valve disease undergoing valve surgery is currently unknown. The authors have developed a screening tool, the 25-Geriatric Locomotive Function Scale (GLFS-25), for the early detection of locomotive syndrome (LS). On the covariant description of diffusion in two-dimensional confined environments. Thus, it has higher detection accuracy as the traditional angle-interrogation SPR sensor, with much wider detectable range of refractive index. In addition, this review points to the gaps in the current knowledge base, including the general lack of GWAS and whole-genome sequence analyses particularly understudied populations, and the need for large-scale collaborative effort in both observational and experimental settings. Rates of hazardous and harm-related drinking are higher in the military and veteran populations compared to the general population. Furthermore, it remains unknown how social desirability may influence answers. The immunocytochemical localization of luteinizing hormone-releasing hormone in the brain of the gray short-tailed opossum (Monodelphis domestica). Resting-state EEG recordings can be obtained during the routine clinical process. Eighty-six patients with acute/subacute inflammatory SNN (paraneoplastic, associated with dysimmune diseases, or idiopathic) were retrospectively studied.

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Nutrient bed protection during lower extremity arterial reconstruction. Restoration of MEF2D abolished the effect of Pokemon downregulation on the migration of HCC cells. The main outcome measures investigated were age- and sex-stratified comparison of the non-proctological cohort and the controls, effect of therapeutic intervention on scale values in a subset of patients with haemorrhoidal disease, and sensitivity of the PSS to detect therapeutic failure in this subset of patients. The questionnaire covered symptoms suggestive of lifetime or current asthma (at some point in life or in the last twelve months, respectively). Therefore, we sought to perform a systematic search of the literature to explore the relationship among statins, metformin, and SAMS. The use of dynamic changes in central venous pressure, pulse pressure, and echocardiography for assessment of inferior vena cava diameter variations during respiration allows prediction of fluid volume responsiveness in hemodynamically unstable patients. albicans proved the most sensitive for specific anticandida antibodies. The addition of sodium metabisulfite as a source of sulfur dioxide delayed botulinal outgrowth in perishable canned comminuted pork when it was temperature abused at 27 degree C. It may explain dissimilarities observed in the clinico-immunological profile of rheumatoid arthritis and systemic lupus erythematosus. According to the EU regulations cattle older than 30 months of age (Germany 24 months) and slaughtered for human consumption must be tested by using BSE rapid tests.

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To describe and classify health technologies predicted in forecasting studies. To examine the relationship between cognitive and balance performance in adolescents with concussion. Immunofluorescent Golgi epithelial cells and other astrocytes are detected in the cerebellum of newborn rat, their number increases rapidly between birth and the 10th postnatal day and then more slowly until the end of the 3rd week. Randomized controlled trial of an e-learning designed behavioral intervention for increasing physical activity behavior in multiple sclerosis. In everyday life we accomplish tasks that require the storage and access of mental representations of different environments that we are not currently perceiving.

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PIVKA II is a useful early diagnostic marker for HCC and may be more sensitive when combined with AFP in Chinese patients. Jan van Bemmel is the second recipient of the IMIA/UMIT Medical Informatics Award of Excellence. The model predicts HCH concentrations in air, seawater, marine sediments, and needles well within an order of magnitude, often within a factor of 2, and reproduces major features of the observed differences in space and time. Data from the DAFNE databank are presented in simple pictorial presentations, which reveal considerable disparities in food habits. Throughout the course of infection, these cellular mechanisms rely heavily on the formation of temporally and spatially regulated virus-host protein-protein interactions. These preliminary results, if confirmed in a larger sample, suggest the feasibility of using the proposed multimodal approach to characterise JA-related brain circuitries and visual pattern in ASD individuals and to monitor longitudinal changes in response to rehabilitative intervention.

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To determine the intravitreous concentration of monokine induced by interferon-gamma (Mig) in patients with diabetic retinopathy (DR) and the relation between Mig and vascular endothelial growth factor (VEGF). Systematic genetic dissection of chitin degradation and uptake in Vibrio cholerae. On day 14 after the challenge, the morbidity, mortality and cure rate in each group were calculated. The results indicate that the photoplethysmographic refilling time can provide a good separation between the three groups when the test is performed in the standing, but not in the sitting, position. Patterned, tubular scaffolds mimic longitudinal and radial mechanics of the neonatal trachea. The use of art as a common ground communication tool is presented with particular reference to the medium of magazine picture collage work. Dyssynchrony parameters were associated with CRT response using univariate regression analysis and C-statistics.

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Quality of life in acromegalic patients during long-term somatostatin analog treatment with and without pegvisomant. The author describes model-building as an art which is difficult to communicate, but nevertheless gives valuable tips on the conceptual and practical aspects, from his own considerable experience. Annexin-1 regulated by HAUSP is essential for UV-induced damage response. Further insight into the phenotype associated with a mutation in the ORC6 gene, causing Meier-Gorlin syndrome 3. With columns motrin max dose prepared in such polar solvents as methanol, reversed-phase systems are obtained where compounds separate in order of decreasing polarity. A hybrid supervisory system to support WWTP operation: implementation and validation. Therefore, NFATs may be used as target molecules for the development of therapeutic agents against vascular diseases such as restenosis. Principles in the design of ligand-targeted cancer therapeutics and imaging agents. Management of chronic hepatitis B and C virus infection in GI practice.

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