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Gamaze (Metformin)

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Gamaze is a drug approved by the U.S. Food and Drug Administration as a prescription medication to treat diabetes. This medication is used to decrease hepatic (liver) glucose production, decrease GI glucose absorption and increase target cell insulin sensitivity.

Other names for this medication:
Asoride, Avimet, Bemet, Cetapin, Chromet, Daomet, Diafer, Diaformin, Diapride, Dmbest, Duomet, Emnorm, Formin, Forminal, Fortamet, Getmet, Glatix, Glibetic, Glimaday, Glimilex, Glitenly, Gluoformin, Glycomet, Glycurb, Glycurub, Glymep, Glyrep, Glysiss, Insumet, Mefinda, Metglib, Metme, Metsafe, Metwa, Minitide, Monomet, Nilconorm, Ovinom, Posmeal, Risicon, Rosimet, Serformin, Sumet, Tgmet, Theraformin, Volabay

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Also known as: Metformin


MetFORMIN (Eqv-{name} XR) is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

MetFORMIN (Eqv-{name} XR) is sometimes used together with insulin or other medications, but MetFORMIN (Eqv-{name} XR) is not for treating type 1 diabetes.


Usual Adult Dose for Diabetes Type 2:

Immediate-release: Initial dose: 500 mg orally twice a day or 850 mg orally once a day Dose titration: Increase in 500 mg weekly increments or 850 mg every 2 weeks as tolerated Maintenance dose: 2000 mg daily in divided doses Maximum dose: 2550 mg/day Extended-release: Initial dose: 500 to 1000 mg orally once a day Dose titration: Increase in 500 mg weekly increments as tolerated Maintenance dose: 2000 mg daily Maximum dose: 2500 mg daily Comments: -Metformin, if not contraindicated, is the preferred initial pharmacologic agent for treatment of type 2 diabetes mellitus. -Immediate-release: Take in divided doses 2 to 3 times a day with meals; titrate slowly to minimize gastrointestinal side effects. In general, significant responses are not observed with doses less than 1500 mg/day. -Extended-release: Take with the evening meal; if glycemic control is not achieved with 2000 mg once a day, may consider 1000 mg of extended-release product twice a day; if glycemic control is still not achieve, may switch to immediate-release product. Use: To improve glycemic control in adults with type 2 diabetes mellitus as an adjunct to diet and exercise.

Usual Pediatric Dose for Diabetes Type 2:

10 years or older: Immediate-release: Initial dose: 500 mg orally twice a day Dose titration: Increase in 500 mg weekly increments as tolerated Maintenance dose: 2000 mg daily Maximum dose: 2000 mg daily Comments: Take in divided doses 2 to 3 times a day with meals. Titrate slowly to minimize gastrointestinal side effects. Safety and effectiveness of Gamaze extended-release has not been established in pediatric patients less than 18 years of age. Use: To improve glycemic control in children with type 2 diabetes mellitus as an adjunct to diet and exercise.

Detailed Gamaze dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can cause severe hypoglycemia or lactic acidosis.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Gamaze are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not use Gamaze if you are allergic to Gamaze components. Try to be careful with Gamaze while you are pregnant or have nurseling. Gamaze can't be used by patients under 10 years. Gamaze XR (extended-release tablets) can't be used by patients under 17 years. Gamaze is not taken to treat type 1 diabetes. You can normally take insulin while using Gamaze. Do not use Gamaze in case of taking probenecid (Benemid); aspirin and other salicylates; sulfa drugs (Bactrim); beta-blockers; monoamine oxidase inhibitor (MAOI); allergies, colds, asthma medicines; thyroid medicine (Synthroid); seizure medicines (Dilantin); phenothiazines (Compazine); diet pills; isoniazid; steroids; hormones including birth control pills. Try to be careful with Gamaze in case of using such medication as morphine (MS Contin, Kadian, Oramorph); quinidine (Cardioquin, Quinidex, Quinaglute); vancomycin (Vancocin, Lyphocin); cimetidine (Tagamet) or ranitidine (Zantac); nifedipine (Adalat, Procardia); procainamide (Procan, Pronestyl, Procanbid); trimethoprim (Proloprim, Primsol, Bactrim, Cotrim, Septra); amiloride (Midamor) or triamterene (Dyrenium); digoxin (Lanoxin); furosemide (Lasix). Try to avoid Gamaze in case of having lung, kidney, heart or liver disease, high blood pressure, stroke, diabetic ketoacidosis, or kidney failure. Try to avoid Gamaze in case you want to undergo an operation (dental or any other), x-ray or CT scan. Try to avoid unhealthy food. Gamaze can't be used by patients under 10 years. Gamaze XR (extended-release tablets) can't be used by patients under 17 years. If you want to achieve most effective results without any side effects you need to avoid alcohol. It can be dangerous to stop Gamaze taking suddenly.

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