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Leukeran

Leukeran is used treat a certain type of chronic lymphocytic leukemia (CLL; a type of cancer of the white blood cells). Leukeran is in a class of medications called alkylating agents. It works by slowing or stopping the growth of cancer cells in your body.

Other names for this medication:
Chloramax, Chlorambucil

Similar Products:
Claritin, Nexium, Catapres, Biaxin, Glucophage, Zebeta, Aricept

Also known as: Chlorambucil

Description

Leukeran is approved to treat certain types of the following forms of cancer:

  • chronic lymphocytic leukemia (CLL)
  • certain types of non-Hodgkin lymphoma (NHL), such as follicular lymphoma (FL)
  • Hodgkin lymphoma (HL)
With cancer, abnormal (cancer) cells quickly multiply in certain areas of your body. (Cells that multiply are making more cells.)

Leukeran works by slowing cancer cells from multiplying. And the drug also works by killing the cancer cells. While Leukeran doesn’t cure cancer, it can slow the disease from worsening.

How long does it take to work?

Leukeran begins to work after your first dose of the drug. But you may not notice any changes in symptoms caused by your cancer.

This is because Leukeran slows your cancer from worsening. But it doesn’t necessarily treat symptoms of cancer.

Depending on the type of cancer you have, your doctor may order certain tests to see if Leukeran is working for you. In some cases, this may include certain blood or imaging tests.

Talk with your doctor about how’ll they’ll monitor your progress during Leukeran treatment.

Dosage

The Leukeran dosage your doctor prescribes will depend on several factors. These include:

  • the type and severity of the condition you’re using Leukeran to treat
  • your weight
  • how often you take Leukeran
  • other medical conditions you may have
  • results from certain lab tests you’ll have while you’re taking Leukeran
Typically, your doctor will start you on a low dosage. Then they’ll adjust it over time to reach the amount that’s right for you. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

Drug forms and strengths

Leukeran is available as 2-mg tablets that are taken by mouth.

Dosage for chronic lymphocytic leukemia

The usual dose of Leukeran for chronic lymphocytic leukemia (CLL) is 0.1 mg of drug per kilogram of body weight (mg/kg). This dose is typically taken once daily.

Intermittent dosing vs. daily dosing for CLL

In some cases, doctors may prescribe intermittent dosing for Leukeran for CLL rather than daily dosing. With intermittent dosing, the drug is taken once every 2 weeks or once each month. And in these cases, the dose of Leukeran given may be different than the typical dose given.

For some people with CLL, intermittent Leukeran dosing works better than daily dosing. In addition, certain side effects, such as changes in blood cell levels, may be reduced with intermittent dosing.

Dosage for lymphoma

Below we describe the typical doses of Leukeran for certain types of lymphoma that Leukeran is approved to treat.

Dosage for certain types of non-Hodgkin lymphoma (NHL), such as follicular lymphoma (FL)

The usual dose of Leukeran to treat certain types of NHL, such as FL, is 0.1 mg of drug per kg of body weight (mg/kg). This dose is typically taken once each day.

Dosage for Hodgkin lymphoma (HL)

The usual dose of Leukeran to treat HL is 0.2 mg/kg. This dose is typically taken once each day.

Pediatric dosage

The safety and effectiveness of Leukeran hasn’t been studied in children. But in some cases, Leukeran is prescribed for children with certain conditions. (Keep in mind that this is an off-label use of the drug. With off-label use, a drug that’s approved for certain uses is given or being studied for a different use.)

Because the Leukeran hasn’t been approved for use in children, the drug’s manufacturer hasn’t recommended a typical dosage for children.

If you have questions about pediatric dosage for Leukeran, talk with your child’s doctor. They can recommend a dosage of Leukeran for your child’s needs.

What if I miss a dose?

If you miss a dose of Leukeran, call your doctor’s office. You doctor or their medical staff can help you determine when you should take your next dose of the drug. And they’ll recommend whether you should take a dose to make up for the missed dose.

To help make sure that you don’t miss a dose, try setting a reminder on your phone. A medication timer may be useful, too.

Will I need to use this drug long term?

It depends. The number of Leukeran treatment cycles you’ll receive may depend on several factors. These include the type and severity of your cancer, as well as your medical history.

In one study of people with CLL, the people took chlorambucil (the active drug in Leukeran) every 28 days for up to 12 months. And a review of studies found that, across several clinical studies of chlorambucil for CLL treatment, people took between 6 and 12 treatment cycles of the drug.

Leukeran is usually given every day for 3 to 6 weeks. But your doctor may recommend that you take it once every 2 weeks or once each month.

If you have questions about how long you’ll need to take Leukeran, talk with your doctor.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include agitation, fast heartbeats, skin rash, bruising, bleeding gums, nosebleeds, trouble breathing, or signs of infection (fever, chills, weakness).

Storage

Store at room temperature 15 and 30 degrees C (59 and 86 degrees F) away from away from moisture, light and heat. Do not store in the bathroom. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Leukeran are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not be treated with Leukeran if you are allergic to it, or if you have received this medicine in the past without successful treatment of your condition.

You may not be able to receive Leukeran if you've ever had an allergic reaction to another cancer drug such as bendamustine, busulfan, carmustine, dacarbazine, ifosfamide, lomustine, mechlorethamine, melphalan, streptozocin, or temozolomide.

Tell your doctor if you have ever had:

kidney disease; liver disease; a seizure; a head injury or brain tumor; or if you have received radiation or chemotherapy within the past 4 weeks.

Taking Leukeran may increase your risk of developing other types of cancer. Talk to your doctor about your specific risk.

Do not use Leukeran if you are pregnant. It could harm the unborn baby or cause birth defects. Use effective birth control to prevent pregnancy while you are using Leukeran.

This medicine may affect fertility (ability to have children) in both men and women. However, women should still use birth control to prevent pregnancy because Leukeran can harm an unborn baby.

You should not breastfeed while using this medicine.

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Treatment response to systemic corticosteroid in asthmatic children is heterogeneous and may be mediated by epigenetic mechanism(s). Fourier analysis of phase-shifting algorithms for amplitude measurement of interference fringe. This suggests that simulation may be a helpful tool in teaching needle driving skills. A 33-year-old man with bundle-branch block had a normal electrocardiogram at the age of 7, suggesting that inherited bundle-branch block does not necessarily manifest itself during the first years of life. Genetic variation among hepatitis B viruses includes the antigenic variation in the surface antigen (HBsAg) which constitutes the known HBsAg subtypes. Further analysis confirms that PilB functions downstream of the T4P filament but upstream of the Dif proteins. Thus, gene creation is a dynamic force in the evolution of sperm composition and possibly function, which further suggests that acquisition of molecular functionality in sperm may be an influential pathway in the fixation of new genes. Fixation of proximal humerus fractures with a CFR-PEEK plate provides satisfying clinical and radiographic results after 2 years of follow-up.

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With the increasing irradiation dose, the particle size distribution of PLLA wear debris shifted toward the smaller diameter size, and the mean diameter of PLLA wear debris significantly decreased. Optimization of a Solid-Phase Microextraction method for the Gas Chromatography-Mass Spectrometry analysis of blackberry (Rubus ulmifolius Schott) fruit volatiles. Adults of the neotropical social wasp Mischocyttarus drewseni apply a secretion to the nest stem which is repellent to ants foraging for food by scouting and recruiting, and effectively keeps them from gaining access to the nest and discovering the brood. hydroxylation and epoxidation) mediated by the majority of biosynthetic P450s, in this review, we will focus on the unusual P450 enzymes in relation to new chemistry, skeleton construction, and structure re-shaping via their own unique catalytic power or the intriguing protein-protein interactions between P450s and other proteins. Imaging of choroidal hemodynamics in eyes with polypoidal choroidal vasculopathy using laser speckle phenomenon. The hypothesis tested here is whether a healthy lifestyle assessed via a score is associated with glycaemic traits and whether there is an interaction between the lifestyle and known glucose-raising genetic variants in association with glycaemic traits. Decrease of erythrocyte and glomerular membrane negative charges in chronic cadmium poisoning. The present study demonstrated a high predictability of 5-mm diameter regular-platform implants when placed in the posterior maxilla and mandible. This experience will be useful in biosimilar product development to ensure adherence to sound scientific principles.

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cis-Diamminedichloroplatinum(II) accumulation in sensitive and resistant human ovarian carcinoma cells. We experimentally demonstrate the interrogation of an individual Escherichia coli cell using a nanoscale plasmonic V-groove waveguide. Cooperative Oxygen Sensing by the Kidney and Carotid Body in Blood Pressure Control. Lipids of human atheroma: isolation of hydroxyoctade cadienoic acids from advanced aortal lesions. Force-corrosion synergy damage eventually led to multi-degradation failure of the duplex coating. In total, 72 laparoscopic surgeons completed a demo of the game and filled in a questionnaire. Effect of phenylbutazone and ketazone on the aggregation of blood platelets induced by ADP and adrenaline in vitro.

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Moral distress is a very common experience in the nursing profession, and it is one of the main reasons for job dissatisfaction, burnout, and quitting among nurses. The synthesis of carbon nanotubes (CNTs) of desired chiralities and diameters is one of the most important challenges in nanotube science and achieving such selectivity may require a detailed understanding of their growth mechanism. Future studies with non-SCr-based measures are needed to assess whether the mild elevations of serum creatinine are of clinical significance. Nanostructured sodium montmorillonite was prepared via a colloidal chemical approach and deposited onto glassy carbon electrodes (GCE). The general synthetic strategy has been applied in the preparation of novel cationic heterobimetallic ruthenium(ii)-gold(i) complexes that are highly cytotoxic to renal cancer Caki-1 and colon cancer HCT 116 cell lines while showing a synergistic effect and being more selective than their monometallic counterparts. A prompt diagnosis, made thanks to the multidisciplinary contribution, allowed a combined therapeutic approach leading to final favourable outcome, despite several intercurrent complications. 27e exhibited relatively short half-life profiles in rats and dogs. A patient with a carcinosarcoma of the Fallopian tube is presented.

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