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Xabine (Capecitabine)
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Xabine

Xabine is an anticancer medication. Inside the body, this medicine gets converted into 5-fluorouracil (chemical). This chemical hampers the synthesis of genetic materials (RNA and DNA) in the cancer cells, thereby interferes with their growth.

Other names for this medication:
Capecitabine, Capegard, Capehope, Capget, Capiibine, Capres, Capscare, Captabin, Capxcel, Distamine, Naprocap, Xabine, Xelocel

Similar Products:
Arava, Diovan, Aricept, Eldepryl, Urispas, Thorazine, Phenergan, Ativan

Also known as: Capecitabine

Description

{name} (capecitabine) is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body.

{name} is used alone or in combination chemotherapy to treat colon cancer, breast cancer, or colorectal cancer.

{name} is sometimes used when cancer has spread to other parts of the body (metastatic).

Dosage

Usual Adult Dose of Xabine for Colorectal Cancer:

MONOTHERAPY: For first line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles ADJUVANT TREATMENT IN PATIENTS WITH DUKES' C COLON CANCER: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles for a total of 8 cycles (24 weeks) Comments: -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Colorectal Cancer: -As monotherapy for adjuvant treatment in patients with Dukes' C colon cancer who have undergone complete resection of the primary tumor when treatment with fluoropyrimidine therapy alone is preferred; this drug was non-inferior to 5-fluorouracil and leucovorin (5-FU/LV) for disease-free survival (DFS); physicians should consider results of combination chemotherapy trials, which have shown improvement in DFS and OS, when prescribing this drug as a single-agent in the adjuvant treatment of Dukes' C colon cancer -As first-line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred; combination chemotherapy has shown a survival benefit compared to 5-FU/LV alone; survival benefit over 5-FU/LV has not been demonstrated with this drug as monotherapy; use of this drug instead of 5-FU/LV in combinations has not been adequately studied to assure safety or preservation of the survival advantage

Usual Adult Dose of Xabine for Breast Cancer:

MONOTHERAPY: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period combined with docetaxel 75 mg/m2 as a 1 hour IV infusion, every 3 weeks IN COMBINATION WITH DOCETAXEL: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles Comments: -The manufacturer prescribing information for docetaxel should be consulted for premedication advice. -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Breast Cancer: -In combination with docetaxel for the treatment of patients with metastatic breast cancer after failure of prior anthracycline-containing chemotherapy -As monotherapy for the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen or resistant to paclitaxel and for whom further anthracycline therapy is not indicated (e.g., patients who have received cumulative doses of 400 mg/m2 of doxorubicin or doxorubicin equivalents); resistance is defined as progressive disease while on treatment, with or without an initial response, or relapse within 6 months of completing treatment with an anthracycline-containing adjuvant regimen

Detailed Xabine dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Xabine are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not take Xabine if you are allergic to capecitabine or fluorouracil, or if you have:

severe kidney disease.

To make sure Xabine is safe for you, tell your doctor if you have ever had:

a metabolic disorder called DPD (dihydropyrimidine dehydrogenase) deficiency; liver or kidney disease; heart problems; or if you use a blood thinner and you have routine "INR" or prothrombin time tests.

Capecitabine can harm an unborn baby if the mother or the father is using Xabine .

If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using Xabine and for at least 6 months after your last dose. If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose. Tell your doctor right away if a pregnancy occurs.

Pregnancy may be less likely to occur while the mother or the father is using this medicine. Both men and women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

Do not breastfeed while using Xabine, and for at least 2 weeks after your last dose.

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Developing integrative medicine within a common Jewish-Arabic space could have medical as well as social-cultural advantages. Disparities in Age-Associated Cognitive Decline Between African-American and Caucasian Populations: The Roles of Health Literacy and Education. Highly ordered, and conductive inverse opal arrays were made with silica and subsequently coated with tin-doped indium oxide (ITO) via atomic layer deposition (ALD). National smoking rates were found from Swedish National Statistics on smoking habits. The grain size of these films was uniform and nano scale (50-60 nm) which confirmed with TEM.

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The survival of young patients with NCSLC is unexpectedly poor compared with other age groups, suggesting more aggressive disease biology. Both cytokines correlated with clinical scores, suggesting that IL-6 and IL-8 have additive or synergistic effects in perpetuating the chronic pain in FM patients. An elevated level of IL-6 is demonstrated in patients with rheumatoid arthritis and cardiac myxoma, which can explain symptoms of these diseases, such as autoantibody production and increase in acute phase proteins. Why Patients Delay Their First Contact with Health Services After Stroke?. The Self-care Educational Intervention for Patients With Heart Failure: A Study Protocol.

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Study of Regional Left Ventricular Longitudinal Function in Fetuses with Gestational Diabetes Mellitus by Velocity Vector Imaging. by duodeno-pancreatectomy (D.P.) is often indicated because of concurrent chronic pancreatitis or suspected pancreatic carcinoma. This notice sets forth actions taken by the Director, National Institute of Allergy and infectious Diseases (NIAID), by authority of the Director. Before discussing the challenge facing Physiotherapy Education today let us look back at how this challenge was faced in the past. Highlight: Membrane transport in light of structure, function, and evolution.

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376 diabetic patients (446 ulcers) treated in a diabetic foot department in 2014 were examined. The implementation of patient education within the hospital setting can be justified for a variety of reasons. Poly(A)-binding protein 1 (PABP1) has a fundamental role in the regulation of mRNA translation and stability, both of which are crucial for a wide variety of cellular processes. Oxidative damage in the liver of rats treated with glycolaldehyde. Erratum to: Diverging Paths: Understanding Racial Differences in Civic Engagement Among White, African American, and Latina/o Adolescents Using Structural Equation Modeling. These results indicate that SF and GM-CSF/IL-3 have partially overlapping effects on early signal transducing events, as well as striking differences, such as tyrosine phosphorylation of PLC-gamma. Serological Salmonella monitoring in German pig herds: results of the years 2003-2008. Several cDNA clones were isolated, the size of the insert determined by PCR (polymerase chain reaction) amplification, and in situ hybridization was used to determine cellular localization during tooth organ development.

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In this work, the importance of optimising experimental conditions for the analysis of reactor pressure vessel (RPV) steels using atom probe tomography is explored. Experimental results are then presented showing that our phase compensation method enables characterization of the optical phase profile of individual fiberlets. A comparison of trazodone and fluoxetine: implications for a serotonergic mechanism of antidepressant action. Fifty in-patients at a specialist mood disorders unit underwent a detailed longitudinal clinical evaluation (3-6 weeks) and were assessed on a range of standardized measures to characterise their illness according to depression subtype, duration of illness and clinical features-including specifically depressive and manic symptoms and the context in which these occur. Formaldehyde (FA), acetaldehyde (ACT), malondialdehyde (MDA) and acetone (ACON) were simultaneously identified in urine, and their excretion quantitated in response to chemically induced oxidative stress. CBCT images from 10 dry skulls were taken with and without the foramina ovale, spinosum, and rotundum, and the hypoglossal canals filled with radiopaque gutta-percha (gold standard). We present a brief review of the anatomic and pathophysiological rationale for RDN as an adjunctive treatment for ventricular tachyarrhythmias.

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The developed multi-stage principal component analysis method applied at the pre-separation step has reduced the external noises and artifacts significantly. Finally, a large simulation study and an application to real data are used to compare IBF, FBF and the well-known Bayesian information criterion. Fibrous dysplasia (FD) is a rare skeletal disorder, resulting in deformity, fracture, functional impairment, and pain. The present study reports the outcome of a patient with ES-SCLC who responded favorably to initial chemotherapy and received SBRT for a residual mass in the peripheral lung. Mechanical thrombectomy is an emerging treatment strategy for achieving a high recanalization rates.

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Although these two cases suggest that strenuous anaerobic exercise during pregnancy is not harmful, more studies are needed to determine if these cases are isolated. During the 14-day treatment period, plasma LH levels following GnRH analogue (GnRH-A) injections (10.0 micrograms) were significantly reduced after the 6th and the 14th injection. Additionally, the correlation between the orientation, the affinity, and the bending-stretching ratio in the network is discussed. Younger African American (AA) women often present themselves with aggressive form of breast cancer with unique biology which is very difficult to treat. The phthalate metabolite MBzP was strongly related to the echogenicity of intima-media and plaques and also to IMT, independently of traditional CV risk factors. The physiological significance of vWF-dependent SIPA has not been clarified. Regional dysfunction of the right ventricular outflow tract reduces the accuracy of Doppler tissue imaging assessment of global right ventricular systolic function in patients with repaired tetralogy of Fallot.

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Resection of metastasis and local recurrences of renal cell carcinoma after presurgical targeted therapy: probability of complete local control and outcome. Perinatal 192 IgG-saporin lesions allowed investigating the role of the basal forebrain cholinergic system in modulating behavioral functions in developing as well as adult rats. This study examined the in vitro lethal potential of ethyl acetate and methanol extracts of Helianthemum lippii (L.) (sun roses) against Acanthamoeba castellanii cysts isolated from patients with amoebic keratitis. Facial Involuntary Movements and Respiratory Failure in CANOMAD, Responsive to IVIG Therapy. p53 mosaicism with an exon 8 germline mutation in the founder of a cancer-prone pedigree. Eligible controls were required to have undergone a TRUS biopsy at the same surgical institution as the case and in the closest period of time. Percutaneous coronary procedures are undergoing a paradigm shift from femoral to forearm approach due to obvious advantages in terms of patient safety and comfort, and faster time to ambulation. In the theta and low beta bands the difference between oral and silent reading was greater for controls than for dyslexics.

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Estimating nerve excitation thresholds to cutaneous electrical stimulation by finite element modeling combined with a stochastic branching nerve fiber model. Two of these, Wnt-1 and Wnt-3, are implicated in mouse mammary tumor virus-associated adenocarcinomas, although neither member is normally expressed in the mammary gland. In recent work we began to disentangle these possibilities by analyzing reprogramming in the absence of cell division. Previous reports have indicated extremely high mortality for gastroesophageal intussusception, and resolution of megaesophagus in the dog is unusual. However, a recent study by Lin and colleagues reached the opposite conclusion. Pulse lists collected from actual treatments were used to simulate the temperature increase during the ablation process. Here, we show that these antiparasitic cardenolides can also impose significant costs on both uninfected and infected butterflies. Virulence factors of enteric Escherichia coli in young Aboriginal children in north-west Australia.

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Analysis of induced sputum for the diagnosis of recurrent Pneumocystis carinii pneumonia. More than half of the patients required only an overnight hospitalization. To avoid this distortion, a new method of donor site closure is devised. Somatic mosaic females that carry mutations in the Sxl gene develop abnormal genitalia and reproductive tissue. We demonstrate by calculations that very small effective doses are exposed to the blood ( prometrium progesterone capsules 100mg ca 10(-4) J m(-2)). haemolytica glycoprotease may be of use in the affinity purification and recovery of clinically important leukocyte subsets, such as primitive hematopoietic progenitors that express CD34. Quantifying the effects of the division of labor in metabolic pathways. By comparison of data from 23 SLPs, the mechanisms of drug-protein association and the impact of chemical modifications at individual positions on drug uptake can be rationalized. The M-BanIII gene coded for a protein of 580 amino acid residues (MW 66,344).

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The experimental results show that a longer sampling cycle time will increase the stability of the wireless sensor. Major depressive disorder predicts completion, adherence, and outcomes in cardiac rehabilitation: a prospective cohort study of 195 patients with coronary artery disease. Prescribing behaviors of family physicians in the treatment of osteoarthritis. The bilateral glenoid inclination and version angles, measured by the volume rendering technique (VRT) and multi-planar reformation (MPR) of multi-slice computed tomography (MSCT) under 16-slice spiral CT scans, were compared by paired t test in all cases. Consequently, these pregnancies should be closely followed up for maternal and fetus complications.

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Early intervention with serial casting and manipulation minimises disability and prevents ambulatory problems. We provide evidence that intragraft CMV protein expression is associated with end-stage chronic renal allograft dysfunction, that intragraft CMV levels increase as graft function deteriorates, and that CMV protein expression in the grafts soon after transplant is associated with reduced graft survival. In their own words, they discussed their journey of using reflection during the clinical placement period. Consortium makes effort to surmount difficulties, aid university hospitals. The hospital costs (obtained from the health insurance office of Bayonne) of 31 patients suffering from COPD of all stages, were analysed for the year of rehabilitation and for the preceding year. We report a case of liver metastasis from gastric cancer that was effectively controlled with stereotactic radiation therapy (SRT). Genomic correction of familial cardiomyopathy in human engineered cardiac tissues. The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of visual skin examination by a clinician to screen for skin cancer in adults (I statement). Microcapsules can provide a three- can i have alcohol with diflucan dimensional growth environment with a good immunoisolation and biocompatibility for cells, and the microencapsulation of stem cells provides a new technical support for large-scale cell culture with high activities in vitro and long-term preservation, consequently opening up a new alternative for cell transplantation.

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Intraorganizational conflict in the hospital purchasing decision making process. This study confirmed the usefulness of the serotyping scheme for S. We found no defect in development of EM CD4 T cells, but long-term survival of ICOS(-/-) EM CD4 T cells was significantly compromised compared to wild-type cells. This study was conducted to study the frequency of placental infarcts in hypertensive preterm pregnancies and its effects on foetal outcomes. APC-CKO mice developed Bergmann glia normally until the accumulation of beta-catenin started around postnatal day 10 (P10). Thus, transcriptional profiling in differentiating mESC identified a subpopulation of neurons affected by MeHg, and a pharmacological intervention was identified that specifically protected these cells.

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The VapBC1 toxin-antitoxin trileptal generic name complex from Mycobacterium tuberculosis: purification, crystallization and X-ray diffraction analysis. Synthetic data analysis supports the assumption that prediction is very insensitive to specific changes in breathing. Longevity Assurance 5 (LASS5), a member of the LASS/Ceramide Synthases family, synthesizes C16-ceramide and is implicated in tumor biology. Although the use of clinical prediction models for sleep apnea does not replace polysomnography as a tool for its diagnosis, they can optimize the process of deciding when polysomnography is indicated and increase the chance of obtaining positive polysomnography findings. Our goal was to assess and compare the performance of these approaches.

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Hospital-level outcomes were compared before and after risk adjustment for baseline characteristics. The neurological condition of these patients improved from 9.4 points on the Japanese Orthopaedic Association scale preoperatively to 13.5 points at 6 months after surgery. Recommendations From the International Consortium on Professional Nursing Practice in Long-Term Care Homes. Spatiotemporal modeling via VBGMMs provides a means to explore additional applications such as component tracking. Emergency physician perspectives on central venous catheterization in the emergency department: a survey-based study. Anti-biofilm, anti-hemolysis, and anti-virulence activities of black pepper, cananga, myrrh oils, and nerolidol against Staphylococcus aureus. Five monoclonal antibodies (mAbs) directed against the flagellin generic alternative to prograf of Clostridium chauvoei were used to analyse the structural and antigenic characteristics on the bacterial flagellar surface. Evolution of extracorporeal life support (ECLS) technology has added a new dimension to the intensive care management of acute cardiac and/or respiratory failure in adult patients who fail conventional treatment. Until recently, most of the studies had focused on the interactions between anaesthetics and lipid bilayers.

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Higher postnatal enamel carbon and magnesium concentration found in ITD may derive from either impaired mineralization caused by disturbed cellular metabolism or indirect damage to the ameloblasts due to the physical condition. We believe that such an enhancement in sensor response could be useful for next generation sensor systems. Influence of orthopedic treatment on hard and soft facial structures of individuals presenting with Class II, Division 1 malocclusion: a comparative study. High specificity of line-immunoassay based algorithms for recent HIV-1 infection independent of viral subtype and stage of disease. Consequences of sentinel injury in older adults extend well beyond the period typically considered to be an acute injury episode. Furthermore, all major EEG sleep variables were not significantly different between the saline and SRIF infusion night. Despite no change on total body weight, animals fed with HC diet showed increase in serum leptin levels and higher adiposity compared to diet control group. This effect was not ameliorated by encoding for a later memory test, summarizing, or engaging in similar processes at encoding and recall.

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To generate expression of the CII-peptide specifically on B-cell major histocompatibility complex type II, lentiviral-based gene therapy including a B-cell-specific Igk promoter was used. Technological innovation is one of the potential engines to mitigate environmental pollution. Geniposide prevents rotenone-induced apoptosis in primary cultured neurons. All patients come from a locality where since 1984 very actively a natural focus of hantaviral infection was investigated in small mammals, and where formerly groups of farmers were found with a high herd immunity with hantavirus. Exaggerated Theory of Mind functioning (hyper-ToM) was measured by the ToM Storybook Frederik. Here, we present the case of a 16-year-old boy who was referred to our pediatric department for the management of multiple consolidations detected on chest radiography, which was routinely performed when the patient was being evaluated for an ankle fracture. Groundwater salinity and geochemical type influenced the presence of certain species, particularly Stygonitocrella sp.

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We performed extensive sensitivity analyses to test the robustness of results to variation in inputs and assumptions. 134 patients were recruited and underwent MPCT colon with gas insufflation and antispasmodics. Thus one aspect of TGF-beta 1/bFGF synergy may involve modulation of the ECM. Induction of a clinical complete response with chemoradiotherapy, followed by observation via a watch-and-wait approach, has emerged as a management option for patients with rectal cancer. Although mean binocular and monocular acuity of the 5-year-olds were significantly lower than in adults, the distribution of acuity assessments were similar in the children theolair 250 mg and adults. Changes in weight, HbA(1c), and other metabolic parameters were compared at weeks 20 and 40. Erythroblast morphology in refractory anemia with ring sideroblasts and thrombocytosis. Functional interactions between OCA2 and the protein complexes BLOC-1, BLOC-2, and AP-3 inferred from epistatic analyses of mouse coat pigmentation. Considering that family carers of residents who develop dementia later after admission to a nursing home are less likely to be aware, there is room for improving communication strategies toward family carers of nursing home residents.

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Emerging data links different aspects of lipid metabolism to liver regeneration. Finally, we consider how these changes in hippocampal structure may play a role in postpartum cognitive function and mood disorders, as well as age-related cognitive decline. Time trends in leisure time physical activity, smoking, alcohol consumption and body mass index in Danish adults with and without COPD. To evaluate the significance and predictive value of each of the Neonatal Resuscitation Program (NRP)-listed ante- and intrapartum risk factors for the need of neonatal intubation at birth. For patients with knee osteoarthritis, the KOOS-PS appears too restricted in item content to provide a comprehensive estimate of lower extremity functional status level relative to the KOOS Function and Sport subscales. Ratios of leptin to insulin and adiponectin to endothelin are sex-dependently associated with extent of coronary atherosclerosis. The most frequent early complications in the high-dose-rate brachytherapy cohort were infection, cellulitis, and seroma and/or hematoma. We investigated the influence of variants in the genes encoding neuron-restrictive silencer factor (NRSF) and brain-derived neurotrophic factor (BDNF), proteins previously associated with cognition and epilepsy, on cognitive function in people with newly diagnosed epilepsy. HIV-related deaths were not elevated among MSM or breast cancer deaths among WSW. Impact of standard-pressure and low-pressure pneumoperitoneum on shoulder pain following laparoscopic cholecystectomy: a randomised controlled trial.

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